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Atomistry » Chlorine » PDB 7k9v-7kib » 7kda | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7k9v-7kib » 7kda » |
Chlorine in PDB 7kda: Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34Enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34
All present enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34:
2.5.1.6; Protein crystallography data
The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34, PDB code: 7kda
was solved by
A.Padyana,
L.Jin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34
(pdb code 7kda). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34, PDB code: 7kda: Chlorine binding site 1 out of 1 in 7kdaGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Compound 34
![]() Mono view ![]() Stereo pair view
Reference:
Z.Konteatis,
J.Travins,
S.Gross,
K.Marjon,
A.Barnett,
E.Mandley,
B.Nicolay,
R.Nagaraja,
Y.Chen,
Y.Sun,
Z.Liu,
J.Yu,
Z.Ye,
F.Jiang,
W.Wei,
C.Fang,
Y.Gao,
P.Kalev,
M.L.Hyer,
B.Delabarre,
L.Jin,
A.K.Padyana,
L.Dang,
J.Murtie,
S.A.Biller,
Z.Sui,
K.M.Marks.
Discovery of Ag-270, A First-in-Class Oral MAT2A Inhibitor For the Treatment of Tumors with Homozygous Mtap Deletion. J.Med.Chem. 2021.
Page generated: Sun Jul 13 03:16:36 2025
ISSN: ISSN 0022-2623 PubMed: 33829783 DOI: 10.1021/ACS.JMEDCHEM.0C01895 |
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