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Chlorine in PDB 7l7b: Clostridioides Difficile Rnap with Fidaxomicin

Enzymatic activity of Clostridioides Difficile Rnap with Fidaxomicin

All present enzymatic activity of Clostridioides Difficile Rnap with Fidaxomicin:
2.7.7.6;

Other elements in 7l7b:

The structure of Clostridioides Difficile Rnap with Fidaxomicin also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Clostridioides Difficile Rnap with Fidaxomicin (pdb code 7l7b). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Clostridioides Difficile Rnap with Fidaxomicin, PDB code: 7l7b:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7l7b

Go back to Chlorine Binding Sites List in 7l7b
Chlorine binding site 1 out of 2 in the Clostridioides Difficile Rnap with Fidaxomicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Clostridioides Difficile Rnap with Fidaxomicin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1404

b:111.8
occ:1.00
CL1 D:FI81404 0.0 111.8 1.0
C36 D:FI81404 1.8 111.8 1.0
C35 D:FI81404 2.7 111.8 1.0
C37 D:FI81404 2.8 111.8 1.0
O13 D:FI81404 3.0 111.8 1.0
O12 D:FI81404 3.0 111.8 1.0
H71 D:FI81404 3.0 111.8 1.0
HZ2 D:LYS86 3.2 108.7 1.0
H70 D:FI81404 3.7 111.8 1.0
HZ1 D:LYS86 3.8 108.7 1.0
HZ2 D:LYS84 3.8 114.1 1.0
NZ D:LYS86 3.8 108.7 1.0
HZ3 D:LYS84 3.9 114.1 1.0
HZ3 D:LYS86 4.0 108.7 1.0
C34 D:FI81404 4.0 111.8 1.0
C38 D:FI81404 4.1 111.8 1.0
HH11 C:ARG1121 4.1 102.7 1.0
NZ D:LYS84 4.2 114.1 1.0
HZ1 D:LYS84 4.2 114.1 1.0
HH12 C:ARG1121 4.3 102.7 1.0
NH1 C:ARG1121 4.6 102.7 1.0
C39 D:FI81404 4.6 111.8 1.0
HG11 C:VAL1117 4.7 101.1 1.0
HG13 C:VAL1117 4.8 101.1 1.0

Chlorine binding site 2 out of 2 in 7l7b

Go back to Chlorine Binding Sites List in 7l7b
Chlorine binding site 2 out of 2 in the Clostridioides Difficile Rnap with Fidaxomicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Clostridioides Difficile Rnap with Fidaxomicin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1404

b:111.8
occ:1.00
CL2 D:FI81404 0.0 111.8 1.0
C38 D:FI81404 1.8 111.8 1.0
H70 D:FI81404 2.6 111.8 1.0
H43 D:FI81404 2.7 111.8 1.0
C37 D:FI81404 2.7 111.8 1.0
C39 D:FI81404 2.8 111.8 1.0
O12 D:FI81404 2.9 111.8 1.0
C40 D:FI81404 3.2 111.8 1.0
H45 D:FI81404 3.3 111.8 1.0
HG22 C:VAL1120 3.4 97.9 1.0
HD3 C:ARG1121 3.5 102.7 1.0
HG21 C:VAL1120 3.7 97.9 1.0
C41 D:FI81404 3.8 111.8 1.0
HG23 C:VAL1120 3.8 97.9 1.0
CG2 C:VAL1120 3.9 97.9 1.0
H44 D:FI81404 4.0 111.8 1.0
HG3 C:ARG1121 4.0 102.7 1.0
C36 D:FI81404 4.0 111.8 1.0
HD2 C:ARG1121 4.0 102.7 1.0
C34 D:FI81404 4.1 111.8 1.0
CD C:ARG1121 4.2 102.7 1.0
H46 D:FI81404 4.2 111.8 1.0
HG13 C:VAL1117 4.5 101.1 1.0
HH11 C:ARG1121 4.5 102.7 1.0
H47 D:FI81404 4.5 111.8 1.0
C35 D:FI81404 4.6 111.8 1.0
CG C:ARG1121 4.6 102.7 1.0
HA C:VAL1117 4.9 101.1 1.0

Reference:

X.Cao, H.Boyaci, J.Chen, Y.Bao, R.Landick, E.A.Campbell. Basis of Narrow-Spectrum Activity of Fidaxomicin on Clostridioides Difficile. Nature V. 604 541 2022.
ISSN: ESSN 1476-4687
PubMed: 35388215
DOI: 10.1038/S41586-022-04545-Z
Page generated: Sun Jul 13 03:36:58 2025

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