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Chlorine in PDB 7lv5: The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution

Enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution

All present enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution:
4.2.1.20;

Protein crystallography data

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution, PDB code: 7lv5 was solved by E.Hilario, M.F.Dunn, L.J.Mueller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.14 / 1.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 182.149, 59.18, 67.354, 90, 94.81, 90
R / Rfree (%) 12.9 / 17.9

Other elements in 7lv5:

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Caesium (Cs) 5 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution (pdb code 7lv5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution, PDB code: 7lv5:

Chlorine binding site 1 out of 1 in 7lv5

Go back to Chlorine Binding Sites List in 7lv5
Chlorine binding site 1 out of 1 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'- Trifluoromethoxybenzenesulfonyl)-2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl412

b:75.6
occ:1.00
CG B:TYR8 4.0 11.6 1.0
CD2 B:TYR8 4.1 12.5 1.0
O B:HOH560 4.1 25.9 1.0
O B:HOH535 4.1 34.1 1.0
CE2 B:TYR8 4.2 13.3 1.0
CD1 B:TYR8 4.2 12.3 1.0
CZ B:TYR8 4.4 14.7 1.0
CE1 B:TYR8 4.4 14.2 1.0
O B:GLY10 4.4 13.9 1.0
O B:HOH691 4.5 37.2 1.0
O B:HOH927 4.5 53.5 1.0
CB B:TYR8 4.7 9.6 1.0
O B:HOH524 4.7 34.1 1.0

Reference:

E.Hilario, M.F.Dunn, L.J.Mueller. The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Inhibitor N-(4'-Trifluoromethoxybenzenesulfonyl) -2-Amino-1-Ethylphosphate (F9F) at the Enzyme Alpha-Site, Cesium Ion at the Metal Coordination Site and L-Histidine at the Enzyme Beta-Site at 1.55 Angstrom Resolution To Be Published.
Page generated: Sun Jul 13 03:52:03 2025

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