Chlorine in PDB 7lvw: Structure of Rsv F in Complex with Vhh CL184

The structure of Structure of Rsv F in Complex with Vhh CL184, PDB code: 7lvw was solved by C.-L.Hsieh, J.S.Mclellan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.25 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	104.49, 200.56, 134.66, 90, 105.87, 90
R / Rfree (%)	20.1 / 23

The binding sites of Chlorine atom in the Structure of Rsv F in Complex with Vhh CL184 (pdb code 7lvw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Structure of Rsv F in Complex with Vhh CL184, PDB code: 7lvw:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Structure of Rsv F in Complex with Vhh CL184


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Rsv F in Complex with Vhh CL184 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:28.1 occ:1.00 O A:HOH803 3.2 27.6 1.0 O A:HOH970 3.2 41.0 1.0 O D:HOH786 3.2 25.1 1.0 O A:HOH749 3.2 26.8 1.0 N D:TYR458 3.3 25.6 1.0 NE1 A:TRP52 3.4 26.5 1.0 CD1 A:TRP52 3.7 27.3 1.0 CD1 D:TYR458 3.8 26.7 1.0 CB D:TYR458 3.9 25.5 1.0 CE A:MET370 4.0 28.8 1.0 O A:SER146 4.0 27.6 1.0 CA D:TYR457 4.2 26.4 1.0 CA D:TYR458 4.2 25.0 1.0 C D:TYR457 4.2 26.2 1.0 CG D:TYR458 4.3 26.1 1.0 O D:LEU456 4.4 27.3 1.0 O A:ALA147 4.5 27.2 1.0 O D:TYR458 4.6 23.4 1.0 CE2 A:TRP52 4.6 26.4 1.0 C A:SER146 4.7 27.0 1.0 CA A:ALA147 4.8 27.1 1.0 NH2 A:ARG49 4.8 27.4 1.0 CE1 D:TYR458 4.8 28.1 1.0 C A:ALA147 4.9 27.2 1.0 C D:TYR458 4.9 25.6 1.0

Chlorine binding site 2 out of 5 in the Structure of Rsv F in Complex with Vhh CL184


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Rsv F in Complex with Vhh CL184 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl603 b:24.4 occ:1.00 O A:HOH852 3.1 20.5 1.0 O B:HOH769 3.2 23.8 1.0 O B:HOH859 3.3 25.1 1.0 NE1 B:TRP52 3.3 23.0 1.0 N A:TYR458 3.4 22.0 1.0 CD1 B:TRP52 3.7 24.2 1.0 CD1 A:TYR458 3.9 23.9 1.0 CB A:TYR458 4.0 22.0 1.0 O B:SER146 4.0 23.9 1.0 CE B:MET370 4.1 25.0 1.0 CA A:TYR457 4.2 22.6 1.0 C A:TYR457 4.2 23.7 1.0 CA A:TYR458 4.2 22.2 1.0 O A:LEU456 4.4 23.6 1.0 CG A:TYR458 4.4 23.6 1.0 O B:ALA147 4.5 25.5 1.0 CE2 B:TRP52 4.6 24.6 1.0 O A:TYR458 4.6 20.8 1.0 CA B:ALA147 4.7 26.7 1.0 C B:SER146 4.7 25.8 1.0 NH2 B:ARG49 4.8 25.5 1.0 C B:ALA147 4.8 25.1 1.0 CB A:TYR457 4.9 22.0 1.0 CE1 A:TYR458 4.9 26.5 1.0 C A:TYR458 5.0 21.8 1.0

Chlorine binding site 3 out of 5 in the Structure of Rsv F in Complex with Vhh CL184


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Rsv F in Complex with Vhh CL184 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:31.6 occ:1.00 O B:HOH839 3.1 23.4 1.0 O D:HOH783 3.3 27.6 1.0 N B:TYR458 3.3 26.0 1.0 NE1 D:TRP52 3.4 26.8 1.0 O B:HOH853 3.4 28.1 1.0 CD1 D:TRP52 3.8 27.6 1.0 CB B:TYR458 3.8 26.9 1.0 CD1 B:TYR458 3.9 28.1 1.0 O D:SER146 4.0 28.3 1.0 CE D:MET370 4.0 27.6 1.0 CA B:TYR458 4.1 26.9 1.0 CA B:TYR457 4.2 26.2 1.0 C B:TYR457 4.3 26.9 1.0 O B:LEU456 4.3 27.3 1.0 CG B:TYR458 4.4 27.2 1.0 O D:ALA147 4.5 27.8 1.0 O B:TYR458 4.6 22.8 1.0 C D:SER146 4.6 28.0 1.0 CE2 D:TRP52 4.7 27.6 1.0 CA D:ALA147 4.7 28.5 1.0 C D:ALA147 4.8 27.6 1.0 NH2 D:ARG49 4.9 26.8 1.0 C B:TYR458 4.9 26.0 1.0 CE1 B:TYR458 5.0 29.4 1.0

Chlorine binding site 4 out of 5 in the Structure of Rsv F in Complex with Vhh CL184


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Rsv F in Complex with Vhh CL184 within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl601 b:28.9 occ:1.00 O E:HOH811 3.1 29.2 1.0 O F:HOH834 3.2 33.3 1.0 O E:HOH828 3.2 32.4 1.0 NE1 F:TRP52 3.3 32.4 1.0 N E:TYR458 3.3 28.7 1.0 CD1 F:TRP52 3.7 33.1 1.0 CD1 E:TYR458 3.9 30.7 1.0 CE F:MET370 3.9 31.8 1.0 CB E:TYR458 4.0 29.4 1.0 O F:SER146 4.0 32.5 1.0 CA E:TYR457 4.1 29.8 1.0 C E:TYR457 4.2 30.6 1.0 CA E:TYR458 4.2 30.0 1.0 O E:LEU456 4.4 29.1 1.0 CG E:TYR458 4.4 30.8 1.0 CE2 F:TRP52 4.6 33.6 1.0 O E:TYR458 4.6 26.9 1.0 O F:ALA147 4.7 33.2 1.0 C F:SER146 4.7 33.1 1.0 CA F:ALA147 4.8 34.1 1.0 NH2 F:ARG49 4.8 31.6 1.0 CB E:TYR457 4.8 29.5 1.0 CE1 E:TYR458 4.9 32.6 1.0 C E:TYR458 5.0 28.8 1.0 C F:ALA147 5.0 33.0 1.0

Chlorine binding site 5 out of 5 in the Structure of Rsv F in Complex with Vhh CL184


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of Rsv F in Complex with Vhh CL184 within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl602 b:39.9 occ:1.00 OG1 E:THR423 2.6 31.1 1.0 OG E:SER425 2.7 31.3 1.0 O E:HOH769 2.8 34.3 1.0 C E:THR423 3.2 30.1 1.0 C E:ALA424 3.2 32.3 1.0 N E:SER425 3.2 30.8 1.0 O E:THR423 3.2 28.0 1.0 N E:ALA424 3.3 28.4 1.0 CB E:SER425 3.3 31.5 1.0 CB E:THR423 3.3 30.0 1.0 CA E:ALA424 3.4 29.0 1.0 N E:SER451 3.8 29.4 1.0 O E:ALA424 3.8 31.4 1.0 CA E:SER425 3.8 31.9 1.0 CA E:THR423 3.9 29.9 1.0 CB E:SER451 4.0 30.7 1.0 OG E:SER451 4.1 32.9 1.0 O E:HOH926 4.1 37.2 1.0 O E:THR449 4.2 29.0 1.0 CA E:VAL450 4.3 29.2 1.0 C E:VAL450 4.3 29.4 1.0 CG1 E:ILE431 4.5 34.6 1.0 O E:HOH751 4.5 36.2 1.0 CA E:SER451 4.5 29.8 1.0 OG1 E:THR449 4.5 29.8 1.0 O E:HOH756 4.6 36.0 1.0 N E:THR423 4.7 28.4 1.0 C E:THR449 4.7 29.9 1.0 O E:HOH935 4.7 37.4 1.0 CG2 E:THR423 4.7 31.5 1.0 N E:VAL450 4.8 28.3 1.0 CB E:ALA424 4.9 30.1 1.0

I.Rossey, C.L.Hsieh, K.Sedeyn, M.Ballegeer, B.Schepens, J.S.Mclellan, X.Saelens. A Vulnerable, Membrane-Proximal Site in Human Respiratory Syncytial Virus F Revealed By A Prefusion-Specific Single-Domain Antibody. J.Virol. 2021.
ISSN: ESSN 1098-5514
PubMed: 33692208
DOI: 10.1128/JVI.02279-20