Atomistry » Chlorine » PDB 7mne-7mzr » 7mxa
Atomistry »
  Chlorine »
    PDB 7mne-7mzr »
      7mxa »

Chlorine in PDB 7mxa: PRMT5:MEP50 Complexed with Inhibitor Pf-06855800

Enzymatic activity of PRMT5:MEP50 Complexed with Inhibitor Pf-06855800

All present enzymatic activity of PRMT5:MEP50 Complexed with Inhibitor Pf-06855800:
2.1.1.320;

Protein crystallography data

The structure of PRMT5:MEP50 Complexed with Inhibitor Pf-06855800, PDB code: 7mxa was solved by M.Mctigue, Y.L.Deng, W.Liu, A.Brooun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 82.12 / 2.71
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.171, 138.016, 178.576, 90, 90, 90
R / Rfree (%) 23.2 / 30.7

Other elements in 7mxa:

The structure of PRMT5:MEP50 Complexed with Inhibitor Pf-06855800 also contains other interesting chemical elements:

Fluorine (F) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the PRMT5:MEP50 Complexed with Inhibitor Pf-06855800 (pdb code 7mxa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the PRMT5:MEP50 Complexed with Inhibitor Pf-06855800, PDB code: 7mxa:

Chlorine binding site 1 out of 1 in 7mxa

Go back to Chlorine Binding Sites List in 7mxa
Chlorine binding site 1 out of 1 in the PRMT5:MEP50 Complexed with Inhibitor Pf-06855800


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of PRMT5:MEP50 Complexed with Inhibitor Pf-06855800 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:71.2
occ:1.00
CL1 A:ZR4701 0.0 71.2 1.0
C15 A:ZR4701 1.7 68.3 1.0
C14 A:ZR4701 2.7 67.2 1.0
C16 A:ZR4701 2.7 66.5 1.0
F1 A:ZR4701 2.9 67.6 1.0
CB A:PHE327 2.9 85.5 1.0
O A:TYR324 3.6 73.2 1.0
C A:PHE327 3.7 86.6 1.0
OE2 A:GLU435 3.7 90.3 1.0
O A:PHE327 3.7 87.1 1.0
CA A:PHE327 3.8 85.5 1.0
OH A:TYR334 3.9 92.7 1.0
CD1 A:TYR324 3.9 66.2 1.0
C13 A:ZR4701 4.0 66.0 1.0
C17 A:ZR4701 4.0 65.5 1.0
CA A:TYR324 4.0 70.5 1.0
CG A:PHE327 4.1 86.3 1.0
N A:GLU328 4.2 87.0 1.0
C A:TYR324 4.3 73.1 1.0
CG A:GLU328 4.4 93.3 1.0
OE2 A:GLU328 4.5 97.9 1.0
C12 A:ZR4701 4.5 65.0 1.0
N A:PHE327 4.6 84.4 1.0
CD A:GLU435 4.6 85.0 1.0
CB A:TYR324 4.6 68.4 1.0
CD2 A:PHE327 4.7 87.2 1.0
CE1 A:TYR324 4.7 66.6 1.0
CG A:TYR324 4.8 66.5 1.0
CD A:GLU328 4.8 96.9 1.0
O A:THR323 4.9 71.0 1.0
OE1 A:GLU435 4.9 83.9 1.0
CA A:GLU328 4.9 87.9 1.0
NZ A:LYS333 5.0 103.3 1.0

Reference:

K.Jensen-Pergakes, J.Tatlock, K.A.Maegley, I.J.Mcalpine, M.A.Mctigue, T.Xie, C.P.Dillon, Y.Wang, S.Yamazaki, N.Spiegel, M.Shi, A.Nemeth, N.Miller, E.Hendrickson, H.Lam, J.Sherrill, C.Y.Chung, E.A.Mcmillan, S.K.Bryant, P.Palde, J.Braganza, A.Brooun, Y.L.Deng, V.Goshtasbi, S.E.Kephart, R.A.Kumpf, W.Liu, R.L.Patman, E.Rui, S.Scales, M.Tran-Dube, F.Wang, M.Wythes, T.A.Paul. Sam Competitive PRMT5 Inhibitor Pf-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated Nsclc with Decreased Liability of Drug Resistance. Mol.Cancer Ther. 2021.
ISSN: ESSN 1538-8514
PubMed: 34737197
DOI: 10.1158/1535-7163.MCT-21-0620
Page generated: Sun Jul 13 04:15:34 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy