Chlorine in PDB 7o0c: Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State

All present enzymatic activity of Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State:
5.4.2.8;

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State, PDB code: 7o0c was solved by S.Ramon-Maiques, A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, B.Perez, V.Rubio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.40 / 2.80
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	70.582, 70.582, 360.801, 90, 90, 120
R / Rfree (%)	21.7 / 26.8

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Sodium	(Na)	1 atom

The binding sites of Chlorine atom in the Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State (pdb code 7o0c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State, PDB code: 7o0c:

Chlorine binding site 1 out of 1 in the Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Phosphomannomutase 2 (PMM2) Wild-Type in Apo State within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl303 b:49.9 occ:1.00 N B:PHE119 2.8 52.3 1.0 N A:PHE119 2.9 50.1 1.0 N B:ILE120 3.5 53.8 1.0 CA B:THR118 3.5 62.1 1.0 N A:ILE120 3.6 48.4 1.0 C B:THR118 3.6 56.7 1.0 CA B:PHE119 3.7 54.5 1.0 CA A:PHE119 3.7 53.4 1.0 CB A:PHE119 3.7 44.2 1.0 N B:THR118 3.8 53.9 1.0 CA A:THR118 3.8 58.2 1.0 CD2 B:PHE119 3.8 48.7 1.0 C A:THR118 3.8 54.1 1.0 CB B:PHE119 3.8 43.6 1.0 C B:PHE119 4.1 61.0 1.0 N A:THR118 4.1 54.4 1.0 C A:PHE119 4.1 50.0 1.0 CD1 A:PHE119 4.2 54.0 1.0 CG B:PHE119 4.3 48.1 1.0 O A:ILE120 4.4 54.2 1.0 O B:ILE120 4.4 53.6 1.0 CG A:PHE119 4.5 45.6 1.0 CA B:ILE120 4.5 55.0 1.0 CD1 A:ILE120 4.6 53.9 1.0 CA A:ILE120 4.7 54.8 1.0 CB B:ILE120 4.8 56.9 1.0 O B:THR118 4.8 54.3 1.0 C B:ILE120 4.8 55.7 1.0 CB B:THR118 4.9 57.0 1.0 CE2 B:PHE119 4.9 43.7 1.0 C A:ILE120 4.9 48.7 1.0 CB A:ILE120 4.9 53.2 1.0 C B:GLY117 5.0 58.2 1.0 O A:THR118 5.0 55.8 1.0

A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, A.Velazquez-Campoy, V.Rubio, B.Perez, S.Ramon-Maiques. Insight on Molecular Pathogenesis and Pharmacochaperoning Potential in Phosphomannomutase 2 Deficiency, Provided By Novel Human Phosphomannomutase 2 Structures. J Inherit Metab Dis V. 45 318 2022.
ISSN: ISSN 1573-2665
PubMed: 34859900
DOI: 10.1002/JIMD.12461