Atomistry » Chlorine » PDB 7o2z-7o6a » 7o69
Atomistry »
  Chlorine »
    PDB 7o2z-7o6a »
      7o69 »

Chlorine in PDB 7o69: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site

Enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site:
1.16.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site, PDB code: 7o69 was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 91.94 / 1.35
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 183.873, 183.873, 183.873, 90, 90, 90
R / Rfree (%) 13.4 / 15.3

Other elements in 7o69:

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms
Iron (Fe) 10 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site (pdb code 7o69). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site, PDB code: 7o69:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 1 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl215

b:16.8
occ:0.80
 O A:HOH530 2.8 24.7 0.4
O A:HOH539 3.2 28.9 1.0
O A:HOH491 3.2 15.7 0.5
N A:PHE12 3.2 9.2 1.0
O A:HOH592 3.4 41.0 1.0
N A:ASN11 3.4 9.6 1.0
O A:PHE12 3.5 11.3 1.0
CG A:ARG9 3.6 10.6 1.0
CD A:ARG9 3.6 12.2 1.0
NE A:ARG9 3.6 11.7 1.0
O A:HOH550 3.7 25.9 1.0
C A:GLN10 3.9 9.3 1.0
CA A:GLN10 4.0 9.3 1.0
C A:PHE12 4.0 9.6 1.0
CA A:PHE12 4.0 9.0 1.0
N A:GLN10 4.0 8.7 1.0
CA A:ASN11 4.1 9.0 1.0
C A:ASN11 4.1 8.8 1.0
O A:HOH491 4.2 13.0 0.5
CB A:PHE12 4.3 9.5 1.0
C A:ARG9 4.3 9.2 1.0
CB A:ARG9 4.5 10.4 1.0
O A:ARG9 4.6 11.3 1.0
O A:GLN10 4.7 9.5 1.0
CZ A:ARG9 4.9 10.8 1.0

Chlorine binding site 2 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 2 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl216

b:16.0
occ:0.80
 O A:HOH628 2.9 15.5 1.0
O A:HOH356 3.0 30.6 1.0
O A:HOH656 3.1 12.4 1.0
CA A:GLY125 3.6 10.2 1.0
CD A:PRO127 3.6 9.5 1.0
C A:GLY125 3.7 10.1 1.0
N A:PRO127 3.8 8.9 1.0
N A:ASP126 3.9 9.5 1.0
CB A:PRO127 4.0 10.1 1.0
CA A:PRO127 4.1 9.6 1.0
O A:GLY125 4.2 10.8 1.0
C A:ASP126 4.2 9.2 1.0
CG A:PRO127 4.3 10.1 1.0
O A:HOH663 4.3 27.0 1.0
O A:HOH634 4.4 23.3 0.4
O A:SER122 4.6 11.3 1.0
N A:GLY125 4.6 10.0 1.0
O A:HOH632 4.6 18.1 0.4
CA A:ASP126 4.6 9.0 1.0
O A:HOH632 4.8 17.5 0.3
O A:ASP126 4.8 8.8 1.0
O A:HOH411 4.9 26.6 1.0
O A:ALA121 5.0 10.3 1.0
CA A:SER122 5.0 13.2 0.3
CA A:SER122 5.0 10.0 0.7

Chlorine binding site 3 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 3 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl217

b:13.9
occ:0.70
 ND1 A:HIS151 2.9 10.3 1.0
O A:HOH327 2.9 27.9 1.0
ND2 A:ASN154 3.3 10.6 1.0
O A:ASP150 3.5 8.7 1.0
C A:ASP150 3.5 8.1 1.0
CE1 A:HIS151 3.6 11.1 1.0
O A:HOH344 3.6 32.0 1.0
N A:HIS151 3.6 8.3 1.0
CB A:ASP150 3.7 9.3 1.0
CA A:HIS151 3.7 8.7 1.0
CG2 A:THR174 4.0 11.5 1.0
CG A:HIS151 4.0 9.2 1.0
CG A:ASN154 4.1 9.7 1.0
CE1 A:PHE170 4.1 11.4 1.0
CA A:ASP150 4.3 8.2 1.0
CZ A:PHE170 4.3 10.5 1.0
CB A:ASN154 4.4 9.8 1.0
CB A:HIS151 4.5 8.6 1.0
O A:HOH479 4.7 12.7 1.0
NE2 A:HIS151 4.8 12.3 1.0
CG A:ASP150 4.9 10.2 1.0
C A:HIS151 4.9 8.6 1.0
OG1 A:THR174 4.9 12.0 1.0

Chlorine binding site 4 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 4 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl218

b:120.3
occ:0.25
 FE A:FE2206 2.6 13.8 0.2
NE2 A:HIS173 3.3 12.0 1.0
CE1 A:HIS173 3.4 14.2 1.0
CD2 A:LEU169 3.8 13.4 1.0
ND1 A:HIS173 4.5 12.6 1.0
CD2 A:HIS173 4.5 12.1 1.0
O A:HOH500 4.5 19.8 0.2

Chlorine binding site 5 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 5 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl219

b:19.4
occ:0.80
 NZ A:LYS86 2.9 11.6 0.6
O A:HOH569 3.0 42.9 0.5
NZ A:LYS86 3.3 11.1 0.4
CE A:LYS86 3.5 11.3 0.6
CE A:LYS86 3.6 10.8 0.4
O A:HOH338 4.8 24.6 1.0

Chlorine binding site 6 out of 6 in 7o69

Go back to Chlorine Binding Sites List in 7o69
Chlorine binding site 6 out of 6 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 5 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl220

b:22.6
occ:0.70
 O A:HOH599 3.1 25.2 0.5
N A:LEU165 3.4 10.8 1.0
CB A:LEU165 3.5 10.7 1.0
CB A:ALA163 3.7 15.1 1.0
CG A:LEU165 3.7 11.2 1.0
N A:GLY164 3.8 13.1 1.0
O A:HOH311 4.0 39.4 1.0
C A:ALA163 4.0 12.8 1.0
CA A:LEU165 4.0 9.8 1.0
CD1 A:LEU165 4.0 13.1 1.0
CA A:ALA163 4.2 13.0 1.0
C A:GLY164 4.4 12.2 1.0
O A:ALA163 4.5 15.4 1.0
N A:ALA166 4.5 9.7 1.0
CA A:GLY164 4.6 14.5 1.0
C A:LEU165 4.7 9.8 1.0
O A:HOH473 4.9 47.7 1.0

Reference:

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270
Page generated: Sun Jul 13 04:45:01 2025

Last articles

F in 9RF5
F in 9N6R
F in 9N6P
F in 9N6M
F in 9GSG
F in 9GSD
F in 9GSY
F in 9D02
F in 9D03
F in 9D04
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy