Chlorine in PDB 7oda: Oxa-48-Like Beta-Lactamase Oxa-436

All present enzymatic activity of Oxa-48-Like Beta-Lactamase Oxa-436:
3.5.2.6;

The structure of Oxa-48-Like Beta-Lactamase Oxa-436, PDB code: 7oda was solved by B.A.Lund, A.M.Thomassen, T.J.W.Carlsen, H.K.S.Leiros, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.26 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	69.116, 94.571, 87.762, 90, 109.89, 90
R / Rfree (%)	18.3 / 22.7

The binding sites of Chlorine atom in the Oxa-48-Like Beta-Lactamase Oxa-436 (pdb code 7oda). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Oxa-48-Like Beta-Lactamase Oxa-436, PDB code: 7oda:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Oxa-48-Like Beta-Lactamase Oxa-436


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Oxa-48-Like Beta-Lactamase Oxa-436 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:30.7 occ:1.00 O A:HOH582 2.2 28.5 1.0 HH22 B:ARG206 2.3 12.4 1.0 HH12 B:ARG206 2.3 11.9 1.0 HH22 A:ARG206 2.5 15.2 1.0 HH12 A:ARG206 2.6 14.2 1.0 NH2 B:ARG206 3.1 10.3 1.0 NH1 B:ARG206 3.1 9.9 1.0 HA B:GLN193 3.2 13.0 1.0 NH2 A:ARG206 3.2 12.7 1.0 NH1 A:ARG206 3.3 11.8 1.0 HG3 B:GLN193 3.4 14.3 1.0 HA A:GLN193 3.4 15.0 1.0 HG3 A:GLN193 3.5 18.0 1.0 CZ B:ARG206 3.5 10.2 1.0 CZ A:ARG206 3.7 12.3 1.0 HD22 B:LEU196 3.7 14.0 1.0 HD22 A:LEU196 3.8 14.6 1.0 HH21 B:ARG206 3.8 12.4 1.0 HH11 B:ARG206 3.8 11.9 1.0 HH21 A:ARG206 3.9 15.2 1.0 HH11 A:ARG206 4.0 14.2 1.0 HB2 B:GLN193 4.0 13.4 1.0 CA B:GLN193 4.1 10.8 1.0 O B:HOH508 4.1 31.5 1.0 HB2 A:GLN193 4.2 15.6 1.0 CG B:GLN193 4.3 11.9 1.0 CA A:GLN193 4.3 12.5 1.0 CB B:GLN193 4.3 11.2 1.0 CG A:GLN193 4.3 15.0 1.0 HB2 B:LEU196 4.3 13.8 1.0 CB A:GLN193 4.5 13.0 1.0 HB2 A:LEU196 4.5 14.3 1.0 O A:HOH423 4.6 20.1 1.0 O B:HOH629 4.7 9.8 1.0 CD2 B:LEU196 4.7 11.7 1.0 CD2 A:LEU196 4.7 12.2 1.0 HG2 B:GLN193 4.8 14.3 1.0 O A:HOH572 4.8 19.1 1.0 NE B:ARG206 4.8 9.7 1.0 N B:GLN193 4.8 10.2 1.0 HG2 A:GLN193 4.9 18.0 1.0 HD13 B:LEU196 4.9 15.4 1.0 HD23 B:LEU196 5.0 14.0 1.0 O B:GLN193 5.0 11.1 1.0 HD23 A:LEU196 5.0 14.6 1.0

Chlorine binding site 2 out of 2 in the Oxa-48-Like Beta-Lactamase Oxa-436


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Oxa-48-Like Beta-Lactamase Oxa-436 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl301 b:35.8 occ:1.00 O D:HOH603 2.0 28.9 1.0 HH22 C:ARG206 2.5 14.2 1.0 HH22 D:ARG206 2.5 13.0 1.0 HH12 C:ARG206 2.5 14.6 1.0 HH12 D:ARG206 2.6 13.4 1.0 NH2 C:ARG206 3.2 11.8 1.0 NH1 C:ARG206 3.2 12.1 1.0 HA C:GLN193 3.2 14.4 1.0 NH2 D:ARG206 3.2 10.8 1.0 NH1 D:ARG206 3.3 11.2 1.0 HG3 C:GLN193 3.4 15.3 1.0 HG3 D:GLN193 3.4 15.8 1.0 HA D:GLN193 3.4 14.1 1.0 CZ C:ARG206 3.6 12.0 1.0 CZ D:ARG206 3.7 11.5 1.0 HB2 C:GLN193 3.8 14.7 1.0 HH21 C:ARG206 3.8 14.2 1.0 HH21 D:ARG206 3.9 13.0 1.0 HH11 C:ARG206 3.9 14.6 1.0 HD22 C:LEU196 3.9 13.5 1.0 HB2 D:GLN193 3.9 14.6 1.0 HD22 D:LEU196 4.0 14.9 1.0 HH11 D:ARG206 4.0 13.4 1.0 CA C:GLN193 4.1 12.0 1.0 O D:HOH558 4.1 24.4 1.0 CG C:GLN193 4.2 12.8 1.0 CB C:GLN193 4.2 12.3 1.0 CA D:GLN193 4.3 11.7 1.0 CG D:GLN193 4.3 13.2 1.0 CB D:GLN193 4.3 12.2 1.0 HB2 C:LEU196 4.5 13.7 1.0 HB2 D:LEU196 4.6 14.3 1.0 O D:HOH611 4.7 22.4 1.0 O C:HOH627 4.8 20.1 1.0 HG2 C:GLN193 4.8 15.3 1.0 N C:GLN193 4.8 11.8 1.0 NE C:ARG206 4.9 11.4 1.0 CD2 C:LEU196 4.9 11.2 1.0 HG2 D:GLN193 4.9 15.8 1.0 CD2 D:LEU196 5.0 12.4 1.0 N D:GLN193 5.0 12.0 1.0

B.A.Lund, A.M.Thomassen, T.J.W.Carlsen, H.K.S.Leiros. Biochemical and Biophysical Characterization of the Oxa-48-Like Carbapenemase Oxa-436 Acta Crystallogr.,Sect.F V. 77 2021.
ISSN: ESSN 2053-230X