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Chlorine in PDB 7pqk: Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate
Enzymatic activity of Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate
All present enzymatic activity of Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate:
6.1.1.4;
6.1.1.4;
Protein crystallography data
The structure of Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate, PDB code: 7pqk
was solved by
A.Palencia,
S.Cusack,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.60 / 1.15 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 44.17, 61.8, 77.19, 90, 90, 90 |
| R / Rfree (%) | 13.7 / 16.6 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate
(pdb code 7pqk). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate, PDB code: 7pqk:
In total only one binding site of Chlorine was determined in the Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate, PDB code: 7pqk:
Chlorine binding site 1 out of 1 in 7pqk
Go back to
Chlorine Binding Sites List in 7pqk
Chlorine binding site 1 out
of 1 in the Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Co-Crystal Structure of M. Tuberculosis Leurs in Complex with the Adduct Formed By Prodrug CMPD1 with Adenosine-Monophosphate within 5.0Å range:
|
Reference:
G.Hoffmann,
M.Le Gorrec,
E.Mestdach,
S.Cusack,
L.Salmon,
M.R.Jensen,
A.Palencia.
Adenosine-Dependent Activation Mechanism of Prodrugs Targeting An Aminoacyl-Trna Synthetase. J.Am.Chem.Soc. 2023.
ISSN: ESSN 1520-5126
PubMed: 36599057
DOI: 10.1021/JACS.2C04808
Page generated: Sun Jul 13 05:50:19 2025
ISSN: ESSN 1520-5126
PubMed: 36599057
DOI: 10.1021/JACS.2C04808
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