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Chlorine in PDB 7q5v: Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)

Enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)

All present enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542):
1.14.11.29;

Protein crystallography data

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542), PDB code: 7q5v was solved by W.D.Figg Jr, M.A.Mcdonough, R.Chowdhury, Y.Nakashima, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.88 / 1.17
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 130.914, 38.322, 42.88, 90, 90, 90
R / Rfree (%) 15.7 / 17.9

Other elements in 7q5v:

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) also contains other interesting chemical elements:

Manganese (Mn) 1 atom
Magnesium (Mg) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) (pdb code 7q5v). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542), PDB code: 7q5v:

Chlorine binding site 1 out of 1 in 7q5v

Go back to Chlorine Binding Sites List in 7q5v
Chlorine binding site 1 out of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl509

b:80.8
occ:1.00
 HH22 A:ARG281 1.8 21.1 0.6
HH21 A:ARG281 2.2 21.1 0.6
HH12 A:ARG281 2.2 15.9 0.4
NH2 A:ARG281 2.3 17.6 0.6
HB2 A:SER274 2.6 20.2 0.5
HG A:SER274 2.7 21.8 0.5
OG A:SER274 2.7 18.2 0.5
O A:HOH678 2.8 50.7 1.0
OD1 A:ASP278 2.8 18.1 0.5
O A:HOH635 2.9 14.2 0.5
O A:SER274 2.9 14.2 0.5
O A:SER274 2.9 15.4 0.5
HA A:SER274 3.0 15.9 0.5
NH1 A:ARG281 3.1 13.2 0.4
HA A:SER274 3.1 18.0 0.5
HB2 A:ASP277 3.2 15.7 1.0
CB A:SER274 3.4 16.9 0.5
HH22 A:ARG281 3.4 16.5 0.4
HH11 A:ARG281 3.5 15.9 0.4
CA A:SER274 3.5 15.0 0.5
CG A:ASP278 3.5 15.6 0.5
CA A:SER274 3.6 13.3 0.5
CZ A:ARG281 3.6 16.7 0.6
C A:SER274 3.6 16.5 0.5
C A:SER274 3.6 14.8 0.5
CB A:SER274 3.6 17.6 0.5
HB2 A:ASP278 3.7 23.4 0.5
O A:HOH635 3.7 19.7 0.5
H A:ASP278 3.9 13.5 0.5
H A:ASP278 3.9 18.9 0.5
HB3 A:ASP277 3.9 15.7 1.0
O A:HOH627 3.9 33.6 1.0
OD2 A:ASP278 3.9 19.3 0.5
HH12 A:ARG281 4.0 18.2 0.6
HB3 A:SER274 4.0 20.2 0.5
CZ A:ARG281 4.0 14.1 0.4
HB2 A:SER274 4.0 21.1 0.5
CB A:ASP277 4.0 13.1 1.0
NH2 A:ARG281 4.0 13.8 0.4
N A:ASP278 4.2 11.2 0.5
N A:ASP278 4.2 15.8 0.5
NH1 A:ARG281 4.2 15.1 0.6
OG A:SER274 4.4 23.8 0.5
HB3 A:SER274 4.4 21.1 0.5
HA A:ASP278 4.4 16.3 0.5
HA A:ASP278 4.4 16.5 0.5
HE A:ARG281 4.4 19.0 0.6
NE A:ARG281 4.5 15.8 0.6
CB A:ASP278 4.6 19.5 0.5
CB A:ASP278 4.6 13.9 0.5
CA A:ASP278 4.6 13.7 0.5
CA A:ASP278 4.7 13.6 0.5
O A:HOH623 4.7 22.4 1.0
C A:ASP277 4.7 12.2 1.0
OD2 A:ASP277 4.8 14.2 1.0
N A:SER275 4.9 15.2 1.0
HH21 A:ARG281 4.9 16.5 0.4
HB2 A:ASP278 4.9 16.8 0.5
O A:HOH664 4.9 63.0 1.0
CA A:ASP277 4.9 12.8 1.0
N A:SER274 5.0 13.6 0.5
N A:SER274 5.0 14.7 0.5
CG A:ASP277 5.0 13.1 1.0

Reference:

W.D.Figg Jr, M.A.Mcdonough, R.Chowdhury, Y.Nakashima, C.J.Schofield. Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) To Be Published.
Page generated: Sun Jul 13 06:11:07 2025

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