|
Atomistry » Chlorine » PDB 7q7b-7qgw » 7qga | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7q7b-7qgw » 7qga » |
Chlorine in PDB 7qga: Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open StateEnzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
All present enzymatic activity of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State:
3.1.3.5; Protein crystallography data
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State, PDB code: 7qga
was solved by
N.S.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7qga:
The structure of Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
(pdb code 7qga). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State, PDB code: 7qga: Chlorine binding site 1 out of 1 in 7qgaGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Human CD73 (Ecto 5'-Nucleotidase) in Complex with MRS4598 (A 3-Methyl- Cmpcp Derivative, Compound 16 in Paper) in the Open State
![]() Mono view ![]() Stereo pair view
Reference:
M.Scortichini,
R.M.Idris,
S.Moschutz,
A.Keim,
V.Salmaso,
C.Dobelmann,
P.Oliva,
K.Losenkova,
H.Irjala,
S.Vaittinen,
J.Sandholm,
G.G.Yegutkin,
N.Strater,
A.Junker,
C.E.Muller,
K.A.Jacobson.
Structure-Activity Relationship of 3-Methylcytidine-5'-Alpha , Beta-Methylenediphosphates As CD73 Inhibitors. J.Med.Chem. V. 65 2409 2022.
Page generated: Sun Jul 13 06:18:55 2025
ISSN: ISSN 0022-2623 PubMed: 35080883 DOI: 10.1021/ACS.JMEDCHEM.1C01852 |
Last articlesMn in 9LJUMn in 9LJW Mn in 9LJS Mn in 9LJR Mn in 9LJT Mn in 9LJV Mg in 9UA2 Mg in 9R96 Mg in 9VM1 Mg in 9P01 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |