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Atomistry » Chlorine » PDB 7qip-7qzr » 7qk4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7qip-7qzr » 7qk4 » |
Chlorine in PDB 7qk4: Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)Enzymatic activity of Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)
All present enzymatic activity of Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683):
2.1.1.356; Protein crystallography data
The structure of Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683), PDB code: 7qk4
was solved by
K.Zhao,
M.Zhao,
X.Luo,
H.Zhang,
C.Scheufler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7qk4:
The structure of Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)
(pdb code 7qk4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683), PDB code: 7qk4: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 7qk4Go back to![]() ![]()
Chlorine binding site 1 out
of 3 in the Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 3 in 7qk4Go back to![]() ![]()
Chlorine binding site 2 out
of 3 in the Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)
![]() Mono view ![]() Stereo pair view
Chlorine binding site 3 out of 3 in 7qk4Go back to![]() ![]()
Chlorine binding site 3 out
of 3 in the Eed in Complex with PRC2 Allosteric Inhibitor Compound 22 (MAK683)
![]() Mono view ![]() Stereo pair view
Reference:
Y.Huang,
M.Sendzik,
J.Zhang,
Z.Gao,
Y.Sun,
L.Wang,
J.Gu,
K.Zhao,
Z.Yu,
L.Zhang,
Q.Zhang,
J.Blanz,
Z.Chen,
V.Dubost,
D.Fang,
L.Feng,
X.Fu,
M.Kiffe,
L.Li,
F.Luo,
X.Luo,
Y.Mi,
P.Mistry,
D.Pearson,
A.Piaia,
C.Scheufler,
R.Terranova,
A.Weiss,
J.Zeng,
H.Zhang,
J.Zhang,
M.Zhao,
M.P.Dillon,
S.Jeay,
W.Qi,
J.Moggs,
C.Pissot-Soldermann,
E.Li,
P.Atadja,
A.Lingel,
C.Oyang.
Discovery of the Clinical Candidate MAK683: An Eed-Directed, Allosteric, and Selective PRC2 Inhibitor For the Treatment of Advanced Malignancies. J.Med.Chem. V. 65 5317 2022.
Page generated: Sun Jul 13 06:22:19 2025
ISSN: ISSN 0022-2623 PubMed: 35352560 DOI: 10.1021/ACS.JMEDCHEM.1C02148 |
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