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Chlorine in PDB 7rwh: Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998
Enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998
All present enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998:
2.5.1.6;
2.5.1.6;
Protein crystallography data
The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998, PDB code: 7rwh
was solved by
L.Jin,
A.K.Padyana,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 35.95 / 1.17 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 68.56, 94.11, 116.69, 90, 90, 90 |
| R / Rfree (%) | 11.4 / 13.4 |
Other elements in 7rwh:
The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998 also contains other interesting chemical elements:
| Magnesium | (Mg) | 3 atoms |
| Fluorine | (F) | 3 atoms |
| Bromine | (Br) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998
(pdb code 7rwh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998, PDB code: 7rwh:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998, PDB code: 7rwh:
Chlorine binding site 1 out of 1 in 7rwh
Go back to
Chlorine Binding Sites List in 7rwh
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with Sam and Allosteric Inhibitor Agi-41998 within 5.0Å range:
|
Reference:
M.Li,
Z.Konteatis,
N.Nagaraja,
Y.Chen,
S.Zhou,
G.Ma,
S.Gross,
K.Marjon,
M.L.Hyer,
E.Mandley,
M.Lein,
A.K.Padyana,
L.Jin,
S.Tong,
R.Peters,
J.Murtie,
J.Travins,
M.Medeiros,
P.Liu,
V.Frank,
E.T.Judd,
S.A.Biller,
K.M.Marks,
Z.Sui,
S.K.Reznik.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J.Med.Chem. V. 65 4600 2022.
ISSN: ISSN 0022-2623
PubMed: 35293760
DOI: 10.1021/ACS.JMEDCHEM.1C01595
Page generated: Sun Jul 13 06:52:11 2025
ISSN: ISSN 0022-2623
PubMed: 35293760
DOI: 10.1021/ACS.JMEDCHEM.1C01595
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