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Chlorine in PDB 7s7l: Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD)
Enzymatic activity of Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD)
All present enzymatic activity of Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD):
3.4.24.17;
3.4.24.17;
Protein crystallography data
The structure of Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD), PDB code: 7s7l
was solved by
M.Coban,
M.Raeeszadeh-Sarmazdeh,
A.Hockla,
B.Sankaran,
E.S.Radisky,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.60 / 2.34 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 69.332, 69.332, 312.215, 90, 90, 120 |
| R / Rfree (%) | 20.6 / 23.9 |
Other elements in 7s7l:
The structure of Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD) also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Calcium | (Ca) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD)
(pdb code 7s7l). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD), PDB code: 7s7l:
In total only one binding site of Chlorine was determined in the Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD), PDB code: 7s7l:
Chlorine binding site 1 out of 1 in 7s7l
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Chlorine Binding Sites List in 7s7l
Chlorine binding site 1 out
of 1 in the Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Complex of Tissue Inhibitor of Metalloproteinases-1 (Timp-1) Mutant (L34G/M66S/E67Y/L133N/S155L) with Matrix Metalloproteinase-3 Catalytic Domain (Mmp-3CD) within 5.0Å range:
|
Reference:
M.Raeeszadeh-Sarmazdeh,
M.Coban,
S.Mahajan,
A.Hockla,
B.Sankaran,
G.P.Downey,
D.C.Radisky,
E.S.Radisky.
Engineering of Tissue Inhibitor of Metalloproteinases Timp-1 For Fine Discrimination Between Closely Related Stromelysins Mmp-3 and Mmp-10. J.Biol.Chem. V. 298 01654 2022.
ISSN: ESSN 1083-351X
PubMed: 35101440
DOI: 10.1016/J.JBC.2022.101654
Page generated: Sun Jul 13 07:00:21 2025
ISSN: ESSN 1083-351X
PubMed: 35101440
DOI: 10.1016/J.JBC.2022.101654
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