Atomistry » Chlorine » PDB 7rzd-7s9g » 7s8c
Atomistry »
  Chlorine »
    PDB 7rzd-7s9g »
      7s8c »

Chlorine in PDB 7s8c: Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole

Other elements in 7s8c:

The structure of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 13;

Binding sites:

The binding sites of Chlorine atom in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole (pdb code 7s8c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 13 binding sites of Chlorine where determined in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole, PDB code: 7s8c:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 1 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:18.1
occ:1.00
 CL2 A:ECL701 0.0 18.1 1.0
C11 A:ECL701 1.8 18.1 1.0
C13 A:ECL701 2.7 18.1 1.0
C9 A:ECL701 2.7 18.1 1.0
CB A:MET466 3.5 25.9 1.0
CD1 B:LEU496 3.5 16.9 1.0
CG B:LEU496 3.6 16.9 1.0
CA A:MET466 3.6 25.9 1.0
CG2 B:VAL499 3.6 7.9 1.0
N A:MET466 4.0 25.9 1.0
CA B:LEU496 4.0 16.9 1.0
O B:TRP495 4.0 21.5 1.0
C2 A:ECL701 4.0 18.1 1.0
CB B:VAL499 4.0 7.9 1.0
C10 A:ECL701 4.0 18.1 1.0
CG1 B:VAL499 4.3 7.9 1.0
C A:VAL465 4.3 18.4 1.0
CB B:LEU496 4.3 16.9 1.0
O A:VAL465 4.3 18.4 1.0
C B:TRP495 4.4 21.5 1.0
N B:LEU496 4.4 16.9 1.0
CE A:MET466 4.5 25.9 1.0
C1 A:ECL701 4.5 18.1 1.0
CB A:ALA469 4.6 26.8 1.0
CG1 A:VAL465 4.7 18.4 1.0
CG A:MET466 4.8 25.9 1.0
CD2 B:LEU496 4.8 16.9 1.0
C A:MET466 5.0 25.9 1.0
CD1 A:LEU475 5.0 36.1 1.0

Chlorine binding site 2 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 2 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:18.1
occ:1.00
 CL4 A:ECL701 0.0 18.1 1.0
C14 A:ECL701 1.8 18.1 1.0
C15 A:ECL701 2.7 18.1 1.0
C5 A:ECL701 2.8 18.1 1.0
SD A:MET474 3.5 44.2 1.0
CB A:MET474 3.5 44.2 1.0
CE A:MET474 3.7 44.2 1.0
CG A:MET474 4.0 44.2 1.0
C16 A:ECL701 4.0 18.1 1.0
C21 A:ECL701 4.0 18.1 1.0
C17 A:ECL701 4.5 18.1 1.0
CA A:MET474 4.9 44.2 1.0

Chlorine binding site 3 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 3 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:18.1
occ:1.00
 CL8 A:ECL701 0.0 18.1 1.0
C16 A:ECL701 1.8 18.1 1.0
C15 A:ECL701 2.7 18.1 1.0
C17 A:ECL701 2.8 18.1 1.0
C20 A:ECL701 3.1 18.1 1.0
CE1 A:PHE472 3.4 31.5 1.0
C19 A:ECL701 3.5 18.1 1.0
C7 A:ECL701 3.8 18.1 1.0
CD1 A:PHE472 4.0 31.5 1.0
C14 A:ECL701 4.0 18.1 1.0
C21 A:ECL701 4.1 18.1 1.0
N1 A:ECL701 4.1 18.1 1.0
CZ A:PHE472 4.1 31.5 1.0
O20 A:ECL701 4.4 18.1 1.0
C5 A:ECL701 4.6 18.1 1.0
C8 A:ECL701 5.0 18.1 1.0

Chlorine binding site 4 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 4 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl710

b:34.5
occ:1.00
 CZ3 B:TRP583 4.5 86.2 1.0
CZ3 A:TRP583 4.5 84.5 1.0
CZ3 D:TRP583 4.5 88.0 1.0
CZ3 C:TRP583 4.5 94.7 1.0

Chlorine binding site 5 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 5 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl701

b:20.2
occ:1.00
 CL2 B:ECL701 0.0 20.2 1.0
C11 B:ECL701 1.8 20.2 1.0
C13 B:ECL701 2.7 20.2 1.0
C9 B:ECL701 2.7 20.2 1.0
CB B:MET466 3.5 26.8 1.0
CD1 C:LEU496 3.5 16.0 1.0
CG C:LEU496 3.6 16.0 1.0
CA B:MET466 3.6 26.8 1.0
CG2 C:VAL499 3.6 6.8 1.0
CA C:LEU496 3.9 16.0 1.0
N B:MET466 3.9 26.8 1.0
O C:TRP495 4.0 21.0 1.0
CB C:VAL499 4.0 6.8 1.0
C2 B:ECL701 4.0 20.2 1.0
C10 B:ECL701 4.0 20.2 1.0
CG1 C:VAL499 4.2 6.8 1.0
C B:VAL465 4.3 19.1 1.0
CB C:LEU496 4.3 16.0 1.0
O B:VAL465 4.3 19.1 1.0
C C:TRP495 4.4 21.0 1.0
N C:LEU496 4.4 16.0 1.0
CE B:MET466 4.5 26.8 1.0
C1 B:ECL701 4.5 20.2 1.0
CB B:ALA469 4.6 27.7 1.0
CG1 B:VAL465 4.7 19.1 1.0
CG B:MET466 4.7 26.8 1.0
CD2 C:LEU496 4.8 16.0 1.0
C B:MET466 5.0 26.8 1.0

Chlorine binding site 6 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 6 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl701

b:20.2
occ:1.00
 CL4 B:ECL701 0.0 20.2 1.0
C14 B:ECL701 1.8 20.2 1.0
C15 B:ECL701 2.7 20.2 1.0
C5 B:ECL701 2.8 20.2 1.0
SD B:MET474 3.5 45.5 1.0
CB B:MET474 3.5 45.5 1.0
CE B:MET474 3.7 45.5 1.0
CG B:MET474 4.0 45.5 1.0
C16 B:ECL701 4.0 20.2 1.0
C21 B:ECL701 4.0 20.2 1.0
C17 B:ECL701 4.5 20.2 1.0
CA B:MET474 4.9 45.5 1.0

Chlorine binding site 7 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 7 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl701

b:20.2
occ:1.00
 CL8 B:ECL701 0.0 20.2 1.0
C16 B:ECL701 1.8 20.2 1.0
C15 B:ECL701 2.7 20.2 1.0
C17 B:ECL701 2.8 20.2 1.0
C20 B:ECL701 3.1 20.2 1.0
CE1 B:PHE472 3.4 32.7 1.0
C19 B:ECL701 3.5 20.2 1.0
C7 B:ECL701 3.8 20.2 1.0
CD1 B:PHE472 4.0 32.7 1.0
C14 B:ECL701 4.0 20.2 1.0
C21 B:ECL701 4.1 20.2 1.0
CZ B:PHE472 4.1 32.7 1.0
N1 B:ECL701 4.1 20.2 1.0
O20 B:ECL701 4.4 20.2 1.0
C5 B:ECL701 4.6 20.2 1.0
C8 B:ECL701 5.0 20.2 1.0

Chlorine binding site 8 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 8 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl701

b:14.4
occ:1.00
 CL2 C:ECL701 0.0 14.4 1.0
C11 C:ECL701 1.8 14.4 1.0
C13 C:ECL701 2.7 14.4 1.0
C9 C:ECL701 2.7 14.4 1.0
CB C:MET466 3.5 25.8 1.0
CD1 D:LEU496 3.5 16.1 1.0
CG D:LEU496 3.6 16.1 1.0
CA C:MET466 3.6 25.8 1.0
CG2 D:VAL499 3.6 7.3 1.0
CA D:LEU496 3.9 16.1 1.0
N C:MET466 4.0 25.8 1.0
O D:TRP495 4.0 20.6 1.0
CB D:VAL499 4.0 7.3 1.0
C2 C:ECL701 4.0 14.4 1.0
C10 C:ECL701 4.0 14.4 1.0
CG1 D:VAL499 4.2 7.3 1.0
C C:VAL465 4.3 17.6 1.0
CB D:LEU496 4.3 16.1 1.0
O C:VAL465 4.3 17.6 1.0
C D:TRP495 4.4 20.6 1.0
N D:LEU496 4.4 16.1 1.0
CE C:MET466 4.5 25.8 1.0
C1 C:ECL701 4.5 14.4 1.0
CB C:ALA469 4.6 25.9 1.0
CG1 C:VAL465 4.7 17.6 1.0
CG C:MET466 4.8 25.8 1.0
CD2 D:LEU496 4.8 16.1 1.0
C C:MET466 5.0 25.8 1.0
CD1 C:LEU475 5.0 36.0 1.0

Chlorine binding site 9 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 9 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl701

b:14.4
occ:1.00
 CL4 C:ECL701 0.0 14.4 1.0
C14 C:ECL701 1.8 14.4 1.0
C15 C:ECL701 2.7 14.4 1.0
C5 C:ECL701 2.8 14.4 1.0
SD C:MET474 3.5 44.8 1.0
CB C:MET474 3.5 44.8 1.0
CE C:MET474 3.7 44.8 1.0
CG C:MET474 4.0 44.8 1.0
C16 C:ECL701 4.0 14.4 1.0
C21 C:ECL701 4.0 14.4 1.0
C17 C:ECL701 4.5 14.4 1.0
CA C:MET474 4.9 44.8 1.0

Chlorine binding site 10 out of 13 in 7s8c

Go back to Chlorine Binding Sites List in 7s8c
Chlorine binding site 10 out of 13 in the Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Cryo-Em Structure of Human TRPV6 in Complex with Inhibitor Econazole within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl701

b:14.4
occ:1.00
 CL8 C:ECL701 0.0 14.4 1.0
C16 C:ECL701 1.8 14.4 1.0
C15 C:ECL701 2.7 14.4 1.0
C17 C:ECL701 2.8 14.4 1.0
C20 C:ECL701 3.1 14.4 1.0
CE1 C:PHE472 3.4 30.9 1.0
C19 C:ECL701 3.5 14.4 1.0
C7 C:ECL701 3.8 14.4 1.0
CD1 C:PHE472 4.0 30.9 1.0
C14 C:ECL701 4.0 14.4 1.0
C21 C:ECL701 4.1 14.4 1.0
N1 C:ECL701 4.1 14.4 1.0
CZ C:PHE472 4.1 30.9 1.0
O20 C:ECL701 4.4 14.4 1.0
C5 C:ECL701 4.6 14.4 1.0
C8 C:ECL701 5.0 14.4 1.0

Reference:

A.Neuberger, K.D.Nadezhdin, A.I.Sobolevsky. Structural Mechanisms of TRPV6 Inhibition By Ruthenium Red and Econazole. Nat Commun V. 12 6284 2021.
ISSN: ESSN 2041-1723
PubMed: 34725357
DOI: 10.1038/S41467-021-26608-X
Page generated: Sun Jul 13 07:00:35 2025

Last articles

Mn in 9LJU
Mn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy