Chlorine in PDB 7ufv: Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766

All present enzymatic activity of Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766:
2.7.11.1;

The structure of Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766, PDB code: 7ufv was solved by S.Kimani, A.Li, Y.Li, A.Dong, A.Hutchinson, A.Seitova, B.Wilson, R.Al-Awar, M.Vedadi, P.Brown, C.H.Arrowsmith, A.M.Edwards, L.Halabelian, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.98 / 1.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	49.14, 87.875, 73.807, 90, 98.54, 90
R / Rfree (%)	20.4 / 25.4

The structure of Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766 also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766 (pdb code 7ufv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766, PDB code: 7ufv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1401 b:41.6 occ:1.00 CL A:N6O1401 0.0 41.6 1.0 C7 A:N6O1401 1.7 36.4 1.0 C6 A:N6O1401 2.7 35.3 1.0 C8 A:N6O1401 2.7 34.0 1.0 CG2 A:ILE1354 3.5 38.1 1.0 CB A:ALA1311 3.6 35.6 1.0 CD2 A:LEU1357 3.6 44.6 1.0 CE2 A:PHE1330 3.7 37.9 1.0 CD2 A:PHE1330 3.7 36.4 1.0 CG A:LEU1357 3.7 43.3 1.0 N A:LEU1357 3.8 32.7 1.0 C A:ASP1356 4.0 31.2 1.0 C5 A:N6O1401 4.0 35.1 1.0 C3 A:N6O1401 4.0 33.2 1.0 CZ A:PHE1330 4.0 36.2 1.0 CG A:PHE1330 4.0 35.9 1.0 CA A:ASP1356 4.2 32.1 1.0 CB A:LEU1357 4.2 39.9 1.0 CE1 A:PHE1330 4.3 35.0 1.0 CD1 A:PHE1330 4.3 32.0 1.0 C4 A:N6O1401 4.5 32.1 1.0 N A:ASP1356 4.6 34.1 1.0 O A:ASP1356 4.6 31.8 1.0 CA A:LEU1357 4.6 36.4 1.0 CB A:ILE1354 4.7 37.5 1.0 CB A:PHE1330 4.8 35.7 1.0 CA A:ALA1311 4.9 36.9 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1401 b:52.0 occ:1.00 CL B:N6O1401 0.0 52.0 1.0 C7 B:N6O1401 1.7 52.5 1.0 C8 B:N6O1401 2.7 48.1 1.0 C6 B:N6O1401 2.7 51.9 1.0 CD2 B:LEU1357 3.3 56.1 1.0 CB B:ALA1311 3.3 39.8 1.0 CG B:LEU1357 3.5 54.5 1.0 CG2 B:ILE1354 3.6 43.5 1.0 N B:LEU1357 3.6 42.7 1.0 CD2 B:PHE1330 3.7 45.8 1.0 CE2 B:PHE1330 3.8 44.6 1.0 C B:ASP1356 3.8 41.1 1.0 CB B:LEU1357 4.0 50.1 1.0 C5 B:N6O1401 4.0 52.0 1.0 C3 B:N6O1401 4.0 52.9 1.0 CA B:ASP1356 4.0 42.5 1.0 CG B:PHE1330 4.1 45.4 1.0 CZ B:PHE1330 4.2 45.1 1.0 O B:ASP1356 4.3 37.6 1.0 CA B:LEU1357 4.4 47.1 1.0 N B:ASP1356 4.4 39.8 1.0 CD1 B:PHE1330 4.5 45.5 1.0 C4 B:N6O1401 4.5 50.8 1.0 CE1 B:PHE1330 4.5 43.6 1.0 CA B:ALA1311 4.7 40.2 1.0 CB B:PHE1330 4.8 46.2 1.0 CB B:ILE1354 4.8 42.6 1.0 CD1 B:LEU1357 4.9 52.4 1.0 OD1 B:ASP1356 5.0 40.1 1.0

S.Kimani, A.Li, Y.Li, A.Dong, A.Hutchinson, A.Seitova, B.Wilson, R.Al-Awar, M.Vedadi, P.Brown, C.H.Arrowsmith, A.M.Edwards, L.Halabelian, Structural Genomics Consortium (Sgc). Crystal Structure of the Wdr Domain of Human DCAF1 in Complex with Oicr-6766 To Be Published.