|
Atomistry » Chlorine » PDB 7unn-7v15 » 7v10 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7unn-7v15 » 7v10 » |
Chlorine in PDB 7v10: Factor Xia in Complex with Compound 2DEnzymatic activity of Factor Xia in Complex with Compound 2D
All present enzymatic activity of Factor Xia in Complex with Compound 2D:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2D, PDB code: 7v10
was solved by
P.L.Shaffer,
J.Spurlino,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v10:
The structure of Factor Xia in Complex with Compound 2D also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2D
(pdb code 7v10). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2D, PDB code: 7v10: Chlorine binding site 1 out of 1 in 7v10Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2D
![]() Mono view ![]() Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Sun Jul 13 07:59:46 2025
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
Last articlesMn in 9LJUMn in 9LJW Mn in 9LJS Mn in 9LJR Mn in 9LJT Mn in 9LJV Mg in 9UA2 Mg in 9R96 Mg in 9VM1 Mg in 9P01 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |