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Atomistry » Chlorine » PDB 7unn-7v15 » 7v14 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7unn-7v15 » 7v14 » |
Chlorine in PDB 7v14: Factor Xia in Complex with Compound 2HEnzymatic activity of Factor Xia in Complex with Compound 2H
All present enzymatic activity of Factor Xia in Complex with Compound 2H:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2H, PDB code: 7v14
was solved by
P.L.Shaffer,
P.Cedervall,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v14:
The structure of Factor Xia in Complex with Compound 2H also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2H
(pdb code 7v14). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2H, PDB code: 7v14: Chlorine binding site 1 out of 1 in 7v14Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2H
![]() Mono view ![]() Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Sun Jul 13 08:00:06 2025
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
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