Chlorine in PDB 7wgd: X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form.

The structure of X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form., PDB code: 7wgd was solved by D.Joseph, A.Penmatsa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.43 / 3.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	96.388, 140.709, 168.021, 90, 90, 90
R / Rfree (%)	24.4 / 28.6

The structure of X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form. also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form. (pdb code 7wgd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form., PDB code: 7wgd:

Chlorine binding site 1 out of 1 in the X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Thermostabilized Drosophila Dopamine Transporter with Gaba TRANSPORTER1-Like Substitutions in the Binding Site, in Substrate-Free Form. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl703 b:82.1 occ:1.00 OG A:SER320 2.9 78.0 1.0 NE2 A:GLN316 3.0 83.5 1.0 OH A:TYR69 3.1 79.4 1.0 OG A:SER356 3.4 83.6 1.0 CB A:SER320 3.4 82.0 1.0 CB A:PHE53 4.0 77.9 1.0 CD A:GLN316 4.0 86.0 1.0 CB A:SER356 4.0 82.5 1.0 CG A:GLN316 4.1 81.0 1.0 CZ A:TYR69 4.1 81.0 1.0 CD1 A:PHE53 4.1 77.5 1.0 CE2 A:TYR69 4.1 78.7 1.0 CG A:PHE53 4.2 78.4 1.0 ND2 A:ASN49 4.4 83.1 1.0 O A:ALA48 4.4 86.0 1.0 ND2 A:ASN352 4.6 81.2 1.0 O A:GLN316 4.7 76.4 1.0 CG A:ASN49 4.9 79.7 1.0 CA A:ASN49 4.9 76.6 1.0 CA A:SER320 4.9 82.2 1.0 CE1 A:PHE53 5.0 79.5 1.0

D.Joseph, S.R.Nayak, A.Penmatsa. Structural Insights Into Gaba Transport Inhibition Using An Engineered Neurotransmitter Transporter. Embo J. V. 41 10735 2022.
ISSN: ESSN 1460-2075
PubMed: 35796008
DOI: 10.15252/EMBJ.2022110735