Chlorine in PDB 7wpx: Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp

All present enzymatic activity of Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp:
6.1.1.10;

The structure of Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp, PDB code: 7wpx was solved by J.Yi, Z.Cai, H.Qiu, F.Lu, B.Chen, Z.Luo, Q.Gu, J.Xu, H.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	61.45 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	60.888, 71.376, 120.815, 90, 90, 90
R / Rfree (%)	21.3 / 23.6

The binding sites of Chlorine atom in the Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp (pdb code 7wpx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp, PDB code: 7wpx:

Chlorine binding site 1 out of 1 in the Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Methionyl-Trna Synthetase From Staphylococcus Aureus Complexed with A Fragment and Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:33.4 occ:1.00 CL A:2I3602 0.0 33.4 1.0 C A:2I3602 1.7 35.0 1.0 N1 A:2I3602 2.7 35.8 1.0 C1 A:2I3602 2.8 35.8 1.0 OH A:TYR244 3.4 24.1 1.0 O A:ALA240 3.7 27.4 1.0 C2 A:2I3602 3.8 36.5 1.0 CG1 A:ILE12 3.8 27.8 1.0 NE2 A:HIS277 3.8 27.8 1.0 C A:ALA240 3.8 27.0 1.0 N A:2I3602 3.8 36.3 1.0 CZ A:TYR244 3.9 24.7 1.0 OD1 A:ASN243 3.9 25.9 1.0 CB A:ALA240 3.9 27.2 1.0 N A:LEU241 4.0 26.0 1.0 CZ3 A:TRP237 4.0 27.9 1.0 CE1 A:HIS277 4.0 27.4 1.0 CE2 A:TYR244 4.1 24.8 1.0 CA A:LEU241 4.1 25.6 1.0 CD2 A:LEU241 4.1 24.9 1.0 CD1 A:ILE12 4.5 28.2 1.0 N A:ILE12 4.5 27.4 1.0 CA A:ALA240 4.5 27.3 1.0 CG A:LEU241 4.6 25.0 1.0 CE3 A:TRP237 4.6 27.8 1.0 CE1 A:TYR244 4.8 24.6 1.0 CH2 A:TRP237 4.8 28.0 1.0 CB A:LEU241 4.9 25.3 1.0 CD2 A:HIS277 5.0 27.5 1.0

J.Yi, Z.Cai, H.Qiu, F.Lu, Z.Luo, B.Chen, Q.Gu, J.Xu, H.Zhou. Fragment Screening and Structural Analyses Highlight the Atp-Assisted Ligand Binding For Inhibitor Discovery Against Type 1 Methionyl-Trna Synthetase. Nucleic Acids Res. V. 50 4755 2022.
ISSN: ESSN 1362-4962
PubMed: 35474479
DOI: 10.1093/NAR/GKAC285