Chlorine in PDB 7xtq: Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex

The binding sites of Chlorine atom in the Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex (pdb code 7xtq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex, PDB code: 7xtq:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl401 b:76.5 occ:1.00 CL1 R:H8I401 0.0 76.5 1.0 C8 R:H8I401 1.7 76.5 1.0 C9 R:H8I401 2.6 76.5 1.0 C7 R:H8I401 2.8 76.5 1.0 N1 R:H8I401 3.0 76.5 1.0 CD2 R:LEU74 3.1 72.5 1.0 C3 R:H8I401 3.2 76.5 1.0 CD2 R:LEU71 3.2 70.9 1.0 O1 R:H8I401 3.2 76.5 1.0 CD1 R:LEU74 3.3 72.5 1.0 C17 R:H8I401 3.4 76.5 1.0 C18 R:H8I401 3.4 76.5 1.0 C4 R:H8I401 3.7 76.5 1.0 CG R:LEU74 3.8 72.5 1.0 C10 R:H8I401 3.9 76.5 1.0 C12 R:H8I401 4.0 76.5 1.0 C2 R:H8I401 4.1 76.5 1.0 C16 R:H8I401 4.3 76.5 1.0 C13 R:H8I401 4.4 76.5 1.0 C11 R:H8I401 4.4 76.5 1.0 C5 R:H8I401 4.5 76.5 1.0 CB R:LEU74 4.6 72.5 1.0 C6 R:H8I401 4.6 76.5 1.0 NE1 R:TRP75 4.7 75.6 1.0 CG R:LEU71 4.7 70.9 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the R399-Bound Gpbar-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl401 b:76.5 occ:1.00 CL2 R:H8I401 0.0 76.5 1.0 C11 R:H8I401 1.7 76.5 1.0 C10 R:H8I401 2.6 76.5 1.0 C12 R:H8I401 2.7 76.5 1.0 CD1 R:TYR251 3.1 71.4 1.0 CD2 R:LEU166 3.2 72.5 1.0 CB R:TYR251 3.5 71.4 1.0 CG R:TYR251 3.5 71.4 1.0 C9 R:H8I401 3.9 76.5 1.0 CE1 R:TYR251 4.0 71.4 1.0 C7 R:H8I401 4.0 76.5 1.0 CH2 R:TRP75 4.1 75.6 1.0 CA R:TYR251 4.2 71.4 1.0 O R:SER247 4.4 70.6 1.0 CG R:LEU166 4.4 72.5 1.0 C8 R:H8I401 4.4 76.5 1.0 CD1 R:LEU166 4.6 72.5 1.0 CD2 R:TYR251 4.6 71.4 1.0 CB R:SER157 4.6 77.2 1.0 CZ3 R:TRP75 4.7 75.6 1.0 CZ2 R:TRP75 4.7 75.6 1.0 OG R:SER157 4.8 77.2 1.0 C15 R:H8I401 5.0 76.5 1.0 CZ R:TYR251 5.0 71.4 1.0

L.Ma, F.Yang, X.Wu, C.Mao, L.Guo, T.Miao, S.K.Zang, X.Jiang, D.D.Shen, T.Wei, H.Zhou, Q.Wei, S.Li, Q.Shu, S.Feng, C.Jiang, B.Chu, L.Du, J.P.Sun, X.Yu, Y.Zhang, P.Zhang. Structural Basis and Molecular Mechanism of Biased Gpbar Signaling in Regulating Nsclc Cell Growth Via Yap Activity. Proc.Natl.Acad.Sci.Usa V. 119 54119 2022.
ISSN: ESSN 1091-6490
PubMed: 35858343
DOI: 10.1073/PNAS.2117054119