Chlorine in PDB 7y6i: Cryo-Em Structure of Human Sodium-Chloride Cotransporter

The structure of Cryo-Em Structure of Human Sodium-Chloride Cotransporter also contains other interesting chemical elements:

Sodium

(Na)

4 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter (pdb code 7y6i). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter, PDB code: 7y6i:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Sodium-Chloride Cotransporter within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:56.1 occ:1.00 NA A:NA1102 3.1 31.5 1.0 O A:PRO349 3.2 19.9 1.0 O A:HOH1201 3.2 30.0 1.0 CA A:GLY152 3.4 28.2 1.0 CA A:SER350 3.5 21.7 1.0 N A:VAL153 3.5 40.1 1.0 C A:PRO349 3.7 21.4 1.0 N A:GLY152 3.7 34.3 1.0 N A:SER350 3.8 24.1 1.0 C A:GLY152 3.8 31.3 1.0 NE2 A:HIS234 3.9 28.4 1.0 O A:ILE150 3.9 41.3 1.0 N A:ILE154 4.0 25.5 1.0 OG A:SER350 4.2 29.1 1.0 CG1 A:ILE154 4.2 25.5 1.0 CB A:SER350 4.2 14.2 1.0 CB A:ILE154 4.3 31.8 1.0 C A:SER350 4.6 27.4 1.0 CE A:MET233 4.6 28.6 1.0 CG1 A:VAL153 4.6 22.1 1.0 C A:TRP151 4.7 24.1 1.0 CD2 A:HIS234 4.7 28.3 1.0 CE1 A:HIS234 4.7 34.5 1.0 CA A:VAL153 4.7 34.1 1.0 CA A:ILE154 4.7 28.3 1.0 CB A:PRO349 4.8 28.1 1.0 C A:VAL153 4.8 30.9 1.0 O A:SER350 4.8 28.9 1.0 CA A:PRO349 4.9 22.6 1.0 O A:GLY152 4.9 34.0 1.0 N A:LEU155 4.9 29.1 1.0

Chlorine binding site 2 out of 4 in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Sodium-Chloride Cotransporter within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1103 b:41.3 occ:1.00 OH A:TYR540 2.6 26.7 1.0 N A:GLY353 3.1 29.7 1.0 CE1 A:PHE536 3.3 31.4 1.0 CA A:GLY353 3.5 21.7 1.0 N A:ILE354 3.5 33.8 1.0 N A:LEU355 3.6 42.5 1.0 CB A:LEU355 3.6 38.3 1.0 CZ A:TYR540 3.6 29.5 1.0 CE1 A:PHE223 3.7 33.0 1.0 CD1 A:LEU355 3.7 39.0 1.0 C A:GLY353 3.7 26.7 1.0 CE1 A:TYR540 3.8 28.1 1.0 CD1 A:PHE536 4.0 27.6 1.0 CG A:LEU355 4.1 36.2 1.0 O A:HOH1202 4.1 30.0 1.0 CZ A:PHE536 4.1 28.7 1.0 CA A:LEU355 4.2 39.3 1.0 C A:THR352 4.3 26.4 1.0 CZ A:PHE223 4.3 37.9 1.0 CG1 A:ILE354 4.4 33.6 1.0 C A:ILE354 4.5 36.6 1.0 CA A:ILE354 4.5 30.7 1.0 CB A:THR352 4.5 23.6 1.0 CA A:THR352 4.6 22.9 1.0 O A:GLY353 4.6 32.4 1.0 CD1 A:PHE223 4.7 29.1 1.0 CE2 A:TYR540 4.9 25.5 1.0

Chlorine binding site 3 out of 4 in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Human Sodium-Chloride Cotransporter within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1103 b:50.0 occ:1.00 O B:HOH1201 3.1 19.9 1.0 NA B:NA1104 3.1 33.1 1.0 O B:PRO349 3.2 21.5 1.0 CA B:GLY152 3.4 23.6 1.0 N B:VAL153 3.6 38.0 1.0 CA B:SER350 3.6 14.0 1.0 N B:GLY152 3.6 30.6 1.0 C B:PRO349 3.6 23.8 1.0 C B:GLY152 3.7 27.7 1.0 O B:ILE150 3.8 36.1 1.0 N B:SER350 3.8 25.0 1.0 NE2 B:HIS234 3.9 25.8 1.0 N B:ILE154 4.0 23.5 1.0 CG1 B:ILE154 4.0 24.9 1.0 OG B:SER350 4.3 28.1 1.0 CB B:ILE154 4.4 32.3 1.0 CG2 B:VAL153 4.4 24.6 1.0 CB B:SER350 4.5 13.2 1.0 C B:TRP151 4.5 27.5 1.0 CB B:PRO349 4.5 26.8 1.0 CE B:MET233 4.6 27.1 1.0 C B:SER350 4.6 23.3 1.0 O B:GLY152 4.7 30.0 1.0 CD2 B:HIS234 4.7 24.3 1.0 CE1 B:HIS234 4.7 31.6 1.0 CA B:VAL153 4.7 34.2 1.0 CA B:PRO349 4.7 18.2 1.0 CA B:ILE154 4.8 28.7 1.0 C B:VAL153 4.8 31.3 1.0 O B:SER350 4.9 25.0 1.0 C B:ILE150 4.9 27.4 1.0 N B:LEU155 5.0 28.4 1.0

Chlorine binding site 4 out of 4 in the Cryo-Em Structure of Human Sodium-Chloride Cotransporter


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cryo-Em Structure of Human Sodium-Chloride Cotransporter within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1105 b:39.0 occ:1.00 OH B:TYR540 2.7 29.9 1.0 N B:GLY353 3.1 32.9 1.0 CE1 B:PHE536 3.4 28.0 1.0 N B:LEU355 3.4 45.2 1.0 CA B:GLY353 3.5 23.1 1.0 N B:ILE354 3.5 34.2 1.0 CB B:LEU355 3.6 38.7 1.0 C B:GLY353 3.7 26.3 1.0 CZ B:TYR540 3.7 29.2 1.0 CE1 B:PHE223 3.7 32.6 1.0 O B:HOH1202 3.9 38.8 1.0 CE1 B:TYR540 3.9 25.4 1.0 CD1 B:LEU355 3.9 40.6 1.0 CD1 B:PHE536 4.0 26.2 1.0 CA B:LEU355 4.1 39.4 1.0 CG B:LEU355 4.2 37.7 1.0 C B:THR352 4.3 26.7 1.0 CZ B:PHE536 4.3 25.1 1.0 CZ B:PHE223 4.4 37.6 1.0 C B:ILE354 4.4 40.7 1.0 CB B:THR352 4.5 21.3 1.0 CA B:ILE354 4.5 36.3 1.0 CG1 B:ILE354 4.5 36.8 1.0 CA B:THR352 4.6 18.8 1.0 O B:GLY353 4.6 30.0 1.0 N B:ALA356 4.7 47.8 1.0 CD1 B:PHE223 4.7 30.0 1.0 C B:LEU355 4.8 41.2 1.0 CE2 B:TYR540 5.0 26.9 1.0

J.Nan, Y.Yuan, X.Yang, Z.Shan, H.Liu, F.Wei, W.Zhang, Y.Zhang. Cryo-Em Structure of the Human Sodium-Chloride Cotransporter Ncc. Sci Adv V. 8 D7176 2022.
ISSN: ESSN 2375-2548
PubMed: 36351028
DOI: 10.1126/SCIADV.ADD7176