Chlorine in PDB 7z2g: Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine

Enzymatic activity of Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine

All present enzymatic activity of Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;

Other elements in 7z2g:

The structure of Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine (pdb code 7z2g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine, PDB code: 7z2g:

Chlorine binding site 1 out of 1 in 7z2g

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Chlorine Binding Sites List in 7z2g

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl601 b:13.8 occ:1.00	CL	A:2KW601	0.0	13.8	1.0
	C	A:2KW601	1.8	13.8	1.0
	C5	A:2KW601	2.7	13.8	1.0
	C1	A:2KW601	2.8	13.8	1.0
	CB	A:PRO95	3.6	6.6	1.0
	C4	A:2KW601	4.0	13.8	1.0
	C2	A:2KW601	4.1	13.8	1.0
	CD2	A:TYR188	4.1	12.6	1.0
	CZ3	A:TRP229	4.1	19.0	1.0
	CD2	A:TYR181	4.2	8.5	1.0
	CE3	A:TRP229	4.2	19.0	1.0
	CE2	A:TYR188	4.3	12.6	1.0
	CD2	A:LEU100	4.3	8.8	1.0
	CD1	A:LEU100	4.3	8.8	1.0
	CG	A:PRO95	4.4	6.6	1.0
	CH2	A:TRP229	4.4	19.0	1.0
	CD2	A:TRP229	4.5	19.0	1.0
	C3	A:2KW601	4.5	13.8	1.0
	O	A:PRO95	4.6	6.6	1.0
	C	A:PRO95	4.7	6.6	1.0
	CZ2	A:TRP229	4.7	19.0	1.0
	CA	A:PRO95	4.7	6.6	1.0
	CE2	A:TRP229	4.8	19.0	1.0
	CE2	A:TYR181	4.8	8.5	1.0
	CG	A:LEU100	4.8	8.8	1.0
	CG	A:TYR181	4.9	8.5	1.0
	CB	A:TYR181	5.0	8.5	1.0

Reference:

A.K.Singh, B.De Wijngaert, M.Bijnens, K.Uyttersprot, H.Nguyen, S.E.Martinez, D.Schols, P.Herdewijn, C.Pannecouque, E.Arnold, K.Das. Cryo-Em Structures of Wild-Type and E138K/M184I Mutant Hiv-1 Rt/Dna Complexed with Inhibitors Doravirine and Rilpivirine. Proc.Natl.Acad.Sci.Usa V. 119 60119 2022.
ISSN: ESSN 1091-6490
PubMed: 35858448
DOI: 10.1073/PNAS.2203660119

Page generated: Sun Jul 13 08:40:39 2025

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