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Chlorine in PDB 7zcz: Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine
Enzymatic activity of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine
All present enzymatic activity of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine:
2.1.3.2;
2.1.3.2;
Protein crystallography data
The structure of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine, PDB code: 7zcz
was solved by
C.Wang,
B.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.43 / 2.45 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.659, 103.628, 86.864, 90, 117.46, 90 |
| R / Rfree (%) | 17.6 / 21.8 |
Other elements in 7zcz:
The structure of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine
(pdb code 7zcz). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine, PDB code: 7zcz:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine, PDB code: 7zcz:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 7zcz
Go back to
Chlorine Binding Sites List in 7zcz
Chlorine binding site 1 out
of 2 in the Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 7zcz
Go back to
Chlorine Binding Sites List in 7zcz
Chlorine binding site 2 out
of 2 in the Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Truncated Aspartate Transcarbamoylase From Plasmodium Falciparum with Bound Inhibitor 1-(4-Chlorophenyl) Methanamine within 5.0Å range:
|
Reference:
C.Wang,
B.Zhang,
A.Kruger,
X.Du,
L.Visser,
A.S.S.Domling,
C.Wrenger,
M.R.Groves.
Discovery of Small-Molecule Allosteric Inhibitors of Pf Atc As Antimalarials. J.Am.Chem.Soc. V. 144 19070 2022.
ISSN: ESSN 1520-5126
PubMed: 36195578
DOI: 10.1021/JACS.2C08128
Page generated: Sun Jul 13 08:45:36 2025
ISSN: ESSN 1520-5126
PubMed: 36195578
DOI: 10.1021/JACS.2C08128
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