Chlorine in PDB 8ahy: X-Ray Structure of Human Ncs-1 Bound to Ric-8A

The structure of X-Ray Structure of Human Ncs-1 Bound to Ric-8A, PDB code: 8ahy was solved by D.Munoz-Reyes, M.J.Sanchez-Barrena, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	52.24 / 1.70
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	56.635, 56.635, 135.297, 90, 90, 90
R / Rfree (%)	18.6 / 20.8

The structure of X-Ray Structure of Human Ncs-1 Bound to Ric-8A also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Calcium	(Ca)	2 atoms
Sodium	(Na)	1 atom

The binding sites of Chlorine atom in the X-Ray Structure of Human Ncs-1 Bound to Ric-8A (pdb code 8ahy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Ncs-1 Bound to Ric-8A, PDB code: 8ahy:

Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Ncs-1 Bound to Ric-8A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Ncs-1 Bound to Ric-8A within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl501 b:22.8 occ:1.00 HH B:TYR108 2.2 32.7 1.0 H P:ALA416 2.4 31.0 1.0 H P:GLY413 2.4 27.6 1.0 H P:GLY411 2.5 27.1 1.0 HB3 P:ALA415 2.8 30.3 1.0 OH B:TYR108 3.0 27.2 1.0 HA P:THR410 3.0 27.7 1.0 H P:ALA415 3.1 28.5 1.0 HA2 P:GLY413 3.1 26.8 1.0 N P:GLY413 3.2 23.0 1.0 N P:ALA416 3.2 25.9 1.0 N P:GLY411 3.3 22.6 1.0 HB2 P:ALA416 3.3 31.4 1.0 CA P:GLY413 3.4 22.3 1.0 C P:GLY413 3.5 24.4 1.0 HE1 B:TYR108 3.5 25.1 1.0 O P:TYR409 3.6 24.9 1.0 N P:ALA415 3.6 23.8 1.0 HB3 P:ALA416 3.6 31.4 1.0 HD11 B:ILE128 3.6 33.5 1.0 CB P:ALA415 3.6 25.2 1.0 H P:TYR412 3.7 28.9 1.0 HD13 B:ILE128 3.8 33.5 1.0 CB P:ALA416 3.8 26.2 1.0 CA P:THR410 3.8 23.0 1.0 O P:GLY413 3.8 25.6 1.0 HD12 B:ILE128 3.9 33.5 1.0 N P:ASN414 3.9 27.8 1.0 CA P:ALA415 3.9 25.2 1.0 CZ B:TYR108 4.0 23.3 1.0 CD1 B:ILE128 4.0 27.9 1.0 N P:TYR412 4.0 24.1 1.0 H P:ASN414 4.0 33.4 1.0 C P:ALA415 4.0 27.8 1.0 C P:THR410 4.0 24.9 1.0 HG23 P:THR410 4.1 33.0 1.0 HB2 P:ALA415 4.1 30.3 1.0 CE1 B:TYR108 4.1 20.9 1.0 CA P:ALA416 4.1 25.5 1.0 CA P:GLY411 4.1 23.3 1.0 HA2 P:GLY411 4.1 28.0 1.0 C P:GLY411 4.3 26.8 1.0 HB1 P:ALA415 4.3 30.3 1.0 HA3 P:GLY413 4.3 26.8 1.0 C P:TYR412 4.4 26.8 1.0 C P:TYR409 4.4 23.2 1.0 C P:ASN414 4.5 25.1 1.0 HA P:ALA416 4.6 30.6 1.0 N P:THR410 4.6 23.8 1.0 HG22 B:ILE124 4.6 32.0 1.0 HB1 P:ALA416 4.7 31.4 1.0 H P:GLY417 4.8 27.4 1.0 CA P:TYR412 4.8 23.6 1.0 CA P:ASN414 4.8 27.1 1.0 CG2 P:THR410 4.8 27.5 1.0 CB P:THR410 4.9 26.2 1.0 HA P:ALA415 4.9 30.3 1.0

D.Munoz-Reyes, L.J.Mcclelland, S.Arroyo-Urea, S.Sanchez-Yepes, J.Sabin, S.Perez-Suarez, M.Menendez, A.Mansilla, J.Garcia-Nafria, S.Sprang, M.J.Sanchez-Barrena. The Neuronal Calcium Sensor Ncs-1 Regulates the Phosphorylation State and Activity of the Ga Chaperone and Gef Ric-8A. Elife V. 12 2023.
ISSN: ESSN 2050-084X
PubMed: 38018500
DOI: 10.7554/ELIFE.86151