Chlorine in PDB 8bcg: Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86

All present enzymatic activity of Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86:
3.6.4.13;

The structure of Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86, PDB code: 8bcg was solved by K.Vester, B.Loll, M.C.Wahl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.06 / 2.39
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	99.917, 118.915, 188.069, 90, 90, 90
R / Rfree (%)	21.4 / 26.9

The binding sites of Chlorine atom in the Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86 (pdb code 8bcg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86, PDB code: 8bcg:

Chlorine binding site 1 out of 1 in the Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human BRR2 Helicase Region in Complex with C-Tail Deleted JAB1 and Compound 86 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl2201 b:64.8 occ:1.00 CL14 B:Q9I2201 0.0 64.8 1.0 C11 B:Q9I2201 1.8 57.9 1.0 C10 B:Q9I2201 2.7 56.2 1.0 C12 B:Q9I2201 2.8 56.5 1.0 N B:ILE639 3.7 66.5 1.0 O B:GLU644 3.8 73.1 1.0 C B:ASN638 3.8 69.1 1.0 OG1 B:THR642 3.9 82.3 1.0 CA B:ILE639 3.9 68.8 1.0 O B:ASN638 3.9 73.2 1.0 CG1 B:ILE639 4.0 60.7 1.0 C09 B:Q9I2201 4.0 54.4 1.0 C13 B:Q9I2201 4.1 51.8 1.0 CB B:ASN638 4.1 57.1 1.0 CB B:GLU644 4.1 79.1 1.0 CG1 B:VAL646 4.2 54.6 1.0 C B:GLU644 4.4 75.4 1.0 C08 B:Q9I2201 4.5 49.9 1.0 CB B:ILE639 4.6 65.8 1.0 CB B:VAL646 4.6 50.7 1.0 O B:ALA635 4.6 52.2 1.0 CA B:ASN638 4.6 64.5 1.0 CA B:GLU644 4.8 77.8 1.0

K.Vester, A.Metz, S.Huber, B.Loll, M.C.Wahl. Conformation-Dependent Ligand Hot Spots in the Spliceosomal Rna Helicase, BRR2 To Be Published.