Chlorine in PDB 8dy5: Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A

The structure of Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A, PDB code: 8dy5 was solved by J.Luo, L.E.Boucher, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.25 / 2.20
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	82.43, 226.38, 75.35, 90, 90, 90
R / Rfree (%)	18.8 / 23.2

The structure of Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Calcium	(Ca)	1 atom

The binding sites of Chlorine atom in the Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A (pdb code 8dy5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A, PDB code: 8dy5:

Chlorine binding site 1 out of 1 in the Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Spfv CAT2200 Lh in Complex with Il-17A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:68.5 occ:1.00 O A:TYR186 2.9 29.9 1.0 OD1 A:ASP188 3.5 45.8 1.0 O A:HOH464 3.5 37.8 1.0 OD1 A:ASN1 3.7 73.4 1.0 CB A:SER98 3.7 41.0 1.0 NZ A:LYS191 3.8 44.2 1.0 C A:TYR186 4.0 29.3 1.0 O A:TYR97 4.1 45.1 1.0 CE A:LYS191 4.2 35.8 1.0 CG A:ASP188 4.4 46.1 1.0 N A:ASP188 4.4 30.0 1.0 CA A:ALA187 4.5 30.9 1.0 CA A:SER98 4.6 38.1 1.0 OG A:SER98 4.6 45.3 1.0 C A:TYR97 4.6 41.0 1.0 CZ3 A:TRP173 4.7 28.5 1.0 C A:ALA187 4.7 31.3 1.0 N A:ALA187 4.7 28.3 1.0 OD2 A:ASP188 4.8 48.5 1.0 CG A:ASN1 4.9 65.3 1.0 N A:SER98 4.9 39.4 1.0

L.E.Boucher, E.G.Prinslow, M.Feldkamp, F.Yi, R.Nanjunda, S.J.Wu, T.Liu, E.R.Lacy, S.Jacobs, N.Kozlyuk, B.Del Rosario, B.Wu, P.Aquino, R.C.Davidson, S.Heyne, N.Mazzanti, J.Testa, M.D.Diem, E.Gorre, A.Mahan, H.Nanda, H.P.Gunawardena, A.Gervais, A.A.Armstrong, A.Teplyakov, C.Huang, A.Zwolak, P.Chowdhury, W.C.Cheung, J.Luo. "Stapling" Scfv For Multispecific Biotherapeutics of Superior Properties. Mabs V. 15 95517 2023.
ISSN: ESSN 1942-0870
PubMed: 37074212
DOI: 10.1080/19420862.2023.2195517