Chlorine in PDB 8fcb: Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
Enzymatic activity of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
All present enzymatic activity of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A:
3.6.5.2;
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
(pdb code 8fcb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the
Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A, PDB code: 8fcb:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Chlorine binding site 1 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 1 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl901
b:68.4
occ:1.00
|
CL34
|
A:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C33
|
A:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
A:XQ3901
|
2.8
|
68.4
|
1.0
|
|
C32
|
A:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
A:XQ3901
|
2.8
|
68.4
|
1.0
|
|
HG22
|
A:THR527
|
2.9
|
81.7
|
1.0
|
|
O40
|
A:XQ3901
|
3.0
|
68.4
|
1.0
|
|
O41
|
A:XQ3901
|
3.0
|
68.4
|
1.0
|
|
HD1
|
A:PHE524
|
3.1
|
75.0
|
1.0
|
|
S30
|
A:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HB
|
A:THR527
|
3.3
|
81.7
|
1.0
|
|
HG21
|
A:THR527
|
3.5
|
81.7
|
1.0
|
|
CG2
|
A:THR527
|
3.6
|
81.7
|
1.0
|
|
CD1
|
A:PHE524
|
3.6
|
75.0
|
1.0
|
|
N29
|
A:XQ3901
|
3.7
|
68.4
|
1.0
|
|
OD1
|
A:ASN528
|
3.7
|
83.6
|
1.0
|
|
HA
|
A:PHE524
|
3.8
|
75.0
|
1.0
|
|
C25
|
A:XQ3901
|
3.8
|
68.4
|
1.0
|
|
O
|
A:PHE524
|
3.9
|
75.0
|
1.0
|
|
H291
|
A:XQ3901
|
4.0
|
68.4
|
1.0
|
|
CB
|
A:THR527
|
4.0
|
81.7
|
1.0
|
|
HB2
|
A:ASN528
|
4.0
|
83.6
|
1.0
|
|
HE1
|
A:PHE524
|
4.0
|
75.0
|
1.0
|
|
C36
|
A:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
A:XQ3901
|
4.1
|
68.4
|
1.0
|
|
CE1
|
A:PHE524
|
4.2
|
75.0
|
1.0
|
|
HB3
|
A:TYR553
|
4.2
|
73.5
|
1.0
|
|
CG
|
A:ASN528
|
4.2
|
83.6
|
1.0
|
|
C26
|
A:XQ3901
|
4.3
|
68.4
|
1.0
|
|
HB2
|
A:TYR553
|
4.3
|
73.5
|
1.0
|
|
N
|
A:ASN528
|
4.4
|
83.6
|
1.0
|
|
HG23
|
A:THR527
|
4.4
|
81.7
|
1.0
|
|
HB3
|
A:PHE524
|
4.4
|
75.0
|
1.0
|
|
H
|
A:ASN528
|
4.5
|
83.6
|
1.0
|
|
HA
|
A:ASN528
|
4.5
|
83.6
|
1.0
|
|
CB
|
A:ASN528
|
4.5
|
83.6
|
1.0
|
|
CG
|
A:PHE524
|
4.5
|
75.0
|
1.0
|
|
CA
|
A:PHE524
|
4.5
|
75.0
|
1.0
|
|
H212
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C38
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
O31
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C
|
A:PHE524
|
4.6
|
75.0
|
1.0
|
|
H261
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CB
|
A:TYR553
|
4.6
|
73.5
|
1.0
|
|
C
|
A:THR527
|
4.7
|
81.7
|
1.0
|
|
CB
|
A:PHE524
|
4.7
|
75.0
|
1.0
|
|
CA
|
A:ASN528
|
4.7
|
83.6
|
1.0
|
|
H391
|
A:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N22
|
A:XQ3901
|
4.8
|
68.4
|
1.0
|
|
CG
|
A:TYR553
|
4.9
|
73.5
|
1.0
|
|
HD2
|
A:TYR553
|
4.9
|
73.5
|
1.0
|
|
CA
|
A:THR527
|
5.0
|
81.7
|
1.0
|
|
H201
|
A:XQ3901
|
5.0
|
68.4
|
1.0
|
|
OG1
|
A:THR527
|
5.0
|
81.7
|
1.0
|
|
ND2
|
A:ASN528
|
5.0
|
83.6
|
1.0
|
|
Chlorine binding site 2 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 2 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl901
b:68.4
occ:1.00
|
CL37
|
A:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C36
|
A:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
A:XQ3901
|
2.7
|
68.4
|
1.0
|
|
C38
|
A:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
A:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H381
|
A:XQ3901
|
2.9
|
68.4
|
1.0
|
|
HZ
|
A:PHE592
|
3.0
|
71.4
|
1.0
|
|
H091
|
A:XQ3901
|
3.1
|
68.4
|
1.0
|
|
C09
|
A:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HZ
|
A:PHE524
|
3.3
|
75.0
|
1.0
|
|
H201
|
A:XQ3901
|
3.5
|
68.4
|
1.0
|
|
C10
|
A:XQ3901
|
3.6
|
68.4
|
1.0
|
|
CZ
|
A:PHE524
|
3.7
|
75.0
|
1.0
|
|
OD1
|
A:ASN474
|
3.7
|
68.0
|
1.0
|
|
C08
|
A:XQ3901
|
3.8
|
68.4
|
1.0
|
|
HE1
|
A:PHE524
|
3.8
|
75.0
|
1.0
|
|
H111
|
A:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CZ
|
A:PHE592
|
3.9
|
71.4
|
1.0
|
|
C11
|
A:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CE1
|
A:PHE524
|
4.0
|
75.0
|
1.0
|
|
C33
|
A:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
A:XQ3901
|
4.1
|
68.4
|
1.0
|
|
HE1
|
A:PHE592
|
4.3
|
71.4
|
1.0
|
|
H061
|
A:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C15
|
A:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C07
|
A:XQ3901
|
4.4
|
68.4
|
1.0
|
|
C20
|
A:XQ3901
|
4.4
|
68.4
|
1.0
|
|
HD21
|
A:ASN474
|
4.4
|
68.0
|
1.0
|
|
CE2
|
A:PHE524
|
4.5
|
75.0
|
1.0
|
|
N06
|
A:XQ3901
|
4.5
|
68.4
|
1.0
|
|
HD1
|
A:TYR478
|
4.5
|
66.2
|
1.0
|
|
C32
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CE1
|
A:PHE592
|
4.6
|
71.4
|
1.0
|
|
S16
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HB2
|
A:TYR478
|
4.6
|
66.2
|
1.0
|
|
H202
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CG
|
A:ASN474
|
4.6
|
68.0
|
1.0
|
|
H241
|
A:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HE2
|
A:PHE524
|
4.7
|
75.0
|
1.0
|
|
HE2
|
A:TYR591
|
4.8
|
77.3
|
1.0
|
|
H391
|
A:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N19
|
A:XQ3901
|
4.8
|
68.4
|
1.0
|
|
ND2
|
A:ASN474
|
4.9
|
68.0
|
1.0
|
|
HE2
|
A:PHE592
|
4.9
|
71.4
|
1.0
|
|
C12
|
A:XQ3901
|
4.9
|
68.4
|
1.0
|
|
CE2
|
A:PHE592
|
4.9
|
71.4
|
1.0
|
|
CD1
|
A:PHE524
|
5.0
|
75.0
|
1.0
|
|
Chlorine binding site 3 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 3 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl901
b:68.4
occ:1.00
|
CL34
|
B:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C33
|
B:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
B:XQ3901
|
2.7
|
68.4
|
1.0
|
|
C32
|
B:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
B:XQ3901
|
2.8
|
68.4
|
1.0
|
|
HG22
|
B:THR527
|
2.9
|
81.7
|
1.0
|
|
O40
|
B:XQ3901
|
3.0
|
68.4
|
1.0
|
|
O41
|
B:XQ3901
|
3.0
|
68.4
|
1.0
|
|
HD1
|
B:PHE524
|
3.1
|
75.0
|
1.0
|
|
S30
|
B:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HB
|
B:THR527
|
3.3
|
81.7
|
1.0
|
|
HG21
|
B:THR527
|
3.5
|
81.7
|
1.0
|
|
CG2
|
B:THR527
|
3.6
|
81.7
|
1.0
|
|
CD1
|
B:PHE524
|
3.6
|
75.0
|
1.0
|
|
N29
|
B:XQ3901
|
3.7
|
68.4
|
1.0
|
|
OD1
|
B:ASN528
|
3.7
|
83.6
|
1.0
|
|
HA
|
B:PHE524
|
3.8
|
75.0
|
1.0
|
|
C25
|
B:XQ3901
|
3.8
|
68.4
|
1.0
|
|
O
|
B:PHE524
|
3.9
|
75.0
|
1.0
|
|
H291
|
B:XQ3901
|
4.0
|
68.4
|
1.0
|
|
CB
|
B:THR527
|
4.0
|
81.7
|
1.0
|
|
HB2
|
B:ASN528
|
4.0
|
83.6
|
1.0
|
|
HE1
|
B:PHE524
|
4.0
|
75.0
|
1.0
|
|
C36
|
B:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
B:XQ3901
|
4.1
|
68.4
|
1.0
|
|
CE1
|
B:PHE524
|
4.2
|
75.0
|
1.0
|
|
HB3
|
B:TYR553
|
4.2
|
73.5
|
1.0
|
|
CG
|
B:ASN528
|
4.2
|
83.6
|
1.0
|
|
C26
|
B:XQ3901
|
4.3
|
68.4
|
1.0
|
|
HB2
|
B:TYR553
|
4.3
|
73.5
|
1.0
|
|
N
|
B:ASN528
|
4.4
|
83.6
|
1.0
|
|
HG23
|
B:THR527
|
4.4
|
81.7
|
1.0
|
|
HB3
|
B:PHE524
|
4.4
|
75.0
|
1.0
|
|
H
|
B:ASN528
|
4.5
|
83.6
|
1.0
|
|
HA
|
B:ASN528
|
4.5
|
83.6
|
1.0
|
|
CB
|
B:ASN528
|
4.5
|
83.6
|
1.0
|
|
CG
|
B:PHE524
|
4.5
|
75.0
|
1.0
|
|
CA
|
B:PHE524
|
4.5
|
75.0
|
1.0
|
|
H212
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C38
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
O31
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C
|
B:PHE524
|
4.6
|
75.0
|
1.0
|
|
H261
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CB
|
B:TYR553
|
4.6
|
73.5
|
1.0
|
|
C
|
B:THR527
|
4.7
|
81.7
|
1.0
|
|
CB
|
B:PHE524
|
4.7
|
75.0
|
1.0
|
|
CA
|
B:ASN528
|
4.7
|
83.6
|
1.0
|
|
H391
|
B:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N22
|
B:XQ3901
|
4.8
|
68.4
|
1.0
|
|
CG
|
B:TYR553
|
4.9
|
73.5
|
1.0
|
|
HD2
|
B:TYR553
|
4.9
|
73.5
|
1.0
|
|
CA
|
B:THR527
|
5.0
|
81.7
|
1.0
|
|
H201
|
B:XQ3901
|
5.0
|
68.4
|
1.0
|
|
OG1
|
B:THR527
|
5.0
|
81.7
|
1.0
|
|
ND2
|
B:ASN528
|
5.0
|
83.6
|
1.0
|
|
Chlorine binding site 4 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 4 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl901
b:68.4
occ:1.00
|
CL37
|
B:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C36
|
B:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
B:XQ3901
|
2.7
|
68.4
|
1.0
|
|
C38
|
B:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
B:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H381
|
B:XQ3901
|
2.9
|
68.4
|
1.0
|
|
HZ
|
B:PHE592
|
3.0
|
71.4
|
1.0
|
|
H091
|
B:XQ3901
|
3.1
|
68.4
|
1.0
|
|
C09
|
B:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HZ
|
B:PHE524
|
3.3
|
75.0
|
1.0
|
|
H201
|
B:XQ3901
|
3.5
|
68.4
|
1.0
|
|
C10
|
B:XQ3901
|
3.6
|
68.4
|
1.0
|
|
CZ
|
B:PHE524
|
3.7
|
75.0
|
1.0
|
|
OD1
|
B:ASN474
|
3.7
|
68.0
|
1.0
|
|
C08
|
B:XQ3901
|
3.8
|
68.4
|
1.0
|
|
HE1
|
B:PHE524
|
3.8
|
75.0
|
1.0
|
|
H111
|
B:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CZ
|
B:PHE592
|
3.9
|
71.4
|
1.0
|
|
C11
|
B:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CE1
|
B:PHE524
|
4.0
|
75.0
|
1.0
|
|
C33
|
B:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
B:XQ3901
|
4.1
|
68.4
|
1.0
|
|
HE1
|
B:PHE592
|
4.3
|
71.4
|
1.0
|
|
H061
|
B:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C15
|
B:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C07
|
B:XQ3901
|
4.4
|
68.4
|
1.0
|
|
C20
|
B:XQ3901
|
4.4
|
68.4
|
1.0
|
|
HD21
|
B:ASN474
|
4.4
|
68.0
|
1.0
|
|
CE2
|
B:PHE524
|
4.5
|
75.0
|
1.0
|
|
N06
|
B:XQ3901
|
4.5
|
68.4
|
1.0
|
|
HD1
|
B:TYR478
|
4.5
|
66.2
|
1.0
|
|
C32
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CE1
|
B:PHE592
|
4.6
|
71.4
|
1.0
|
|
S16
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HB2
|
B:TYR478
|
4.6
|
66.2
|
1.0
|
|
H202
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CG
|
B:ASN474
|
4.6
|
68.0
|
1.0
|
|
H241
|
B:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HE2
|
B:PHE524
|
4.7
|
75.0
|
1.0
|
|
HE2
|
B:TYR591
|
4.8
|
77.3
|
1.0
|
|
H391
|
B:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N19
|
B:XQ3901
|
4.8
|
68.4
|
1.0
|
|
ND2
|
B:ASN474
|
4.9
|
68.0
|
1.0
|
|
HE2
|
B:PHE592
|
4.9
|
71.4
|
1.0
|
|
C12
|
B:XQ3901
|
4.9
|
68.4
|
1.0
|
|
CE2
|
B:PHE592
|
4.9
|
71.4
|
1.0
|
|
CD1
|
B:PHE524
|
5.0
|
75.0
|
1.0
|
|
Chlorine binding site 5 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 5 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl1002
b:68.4
occ:1.00
|
CL34
|
C:XQ31002
|
0.0
|
68.4
|
1.0
|
|
C33
|
C:XQ31002
|
1.8
|
68.4
|
1.0
|
|
C35
|
C:XQ31002
|
2.8
|
68.4
|
1.0
|
|
C32
|
C:XQ31002
|
2.8
|
68.4
|
1.0
|
|
H351
|
C:XQ31002
|
2.8
|
68.4
|
1.0
|
|
HG22
|
C:THR527
|
2.9
|
81.7
|
1.0
|
|
O40
|
C:XQ31002
|
3.0
|
68.4
|
1.0
|
|
O41
|
C:XQ31002
|
3.0
|
68.4
|
1.0
|
|
HD1
|
C:PHE524
|
3.1
|
75.0
|
1.0
|
|
S30
|
C:XQ31002
|
3.2
|
68.4
|
1.0
|
|
HB
|
C:THR527
|
3.3
|
81.7
|
1.0
|
|
HG21
|
C:THR527
|
3.5
|
81.7
|
1.0
|
|
CG2
|
C:THR527
|
3.6
|
81.7
|
1.0
|
|
CD1
|
C:PHE524
|
3.6
|
75.0
|
1.0
|
|
N29
|
C:XQ31002
|
3.7
|
68.4
|
1.0
|
|
OD1
|
C:ASN528
|
3.7
|
83.6
|
1.0
|
|
HA
|
C:PHE524
|
3.8
|
75.0
|
1.0
|
|
C25
|
C:XQ31002
|
3.8
|
68.4
|
1.0
|
|
O
|
C:PHE524
|
3.9
|
75.0
|
1.0
|
|
H291
|
C:XQ31002
|
4.0
|
68.4
|
1.0
|
|
CB
|
C:THR527
|
4.0
|
81.7
|
1.0
|
|
HB2
|
C:ASN528
|
4.0
|
83.6
|
1.0
|
|
HE1
|
C:PHE524
|
4.0
|
75.0
|
1.0
|
|
C36
|
C:XQ31002
|
4.0
|
68.4
|
1.0
|
|
C39
|
C:XQ31002
|
4.1
|
68.4
|
1.0
|
|
CE1
|
C:PHE524
|
4.2
|
75.0
|
1.0
|
|
HB3
|
C:TYR553
|
4.2
|
73.5
|
1.0
|
|
CG
|
C:ASN528
|
4.2
|
83.6
|
1.0
|
|
C26
|
C:XQ31002
|
4.3
|
68.4
|
1.0
|
|
HB2
|
C:TYR553
|
4.3
|
73.5
|
1.0
|
|
N
|
C:ASN528
|
4.4
|
83.6
|
1.0
|
|
HG23
|
C:THR527
|
4.4
|
81.7
|
1.0
|
|
HB3
|
C:PHE524
|
4.4
|
75.0
|
1.0
|
|
H
|
C:ASN528
|
4.5
|
83.6
|
1.0
|
|
HA
|
C:ASN528
|
4.5
|
83.6
|
1.0
|
|
CB
|
C:ASN528
|
4.5
|
83.6
|
1.0
|
|
CG
|
C:PHE524
|
4.5
|
75.0
|
1.0
|
|
CA
|
C:PHE524
|
4.5
|
75.0
|
1.0
|
|
H212
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
C38
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
O31
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
C
|
C:PHE524
|
4.6
|
75.0
|
1.0
|
|
H261
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
CB
|
C:TYR553
|
4.6
|
73.5
|
1.0
|
|
C
|
C:THR527
|
4.7
|
81.7
|
1.0
|
|
CB
|
C:PHE524
|
4.7
|
75.0
|
1.0
|
|
CA
|
C:ASN528
|
4.7
|
83.6
|
1.0
|
|
H391
|
C:XQ31002
|
4.8
|
68.4
|
1.0
|
|
N22
|
C:XQ31002
|
4.8
|
68.4
|
1.0
|
|
CG
|
C:TYR553
|
4.9
|
73.5
|
1.0
|
|
HD2
|
C:TYR553
|
4.9
|
73.5
|
1.0
|
|
CA
|
C:THR527
|
5.0
|
81.7
|
1.0
|
|
H201
|
C:XQ31002
|
5.0
|
68.4
|
1.0
|
|
OG1
|
C:THR527
|
5.0
|
81.7
|
1.0
|
|
ND2
|
C:ASN528
|
5.0
|
83.6
|
1.0
|
|
Chlorine binding site 6 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 6 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl1002
b:68.4
occ:1.00
|
CL37
|
C:XQ31002
|
0.0
|
68.4
|
1.0
|
|
C36
|
C:XQ31002
|
1.8
|
68.4
|
1.0
|
|
C35
|
C:XQ31002
|
2.7
|
68.4
|
1.0
|
|
C38
|
C:XQ31002
|
2.8
|
68.4
|
1.0
|
|
H351
|
C:XQ31002
|
2.8
|
68.4
|
1.0
|
|
H381
|
C:XQ31002
|
2.9
|
68.4
|
1.0
|
|
HZ
|
C:PHE592
|
3.0
|
71.4
|
1.0
|
|
H091
|
C:XQ31002
|
3.1
|
68.4
|
1.0
|
|
C09
|
C:XQ31002
|
3.2
|
68.4
|
1.0
|
|
HZ
|
C:PHE524
|
3.3
|
75.0
|
1.0
|
|
H201
|
C:XQ31002
|
3.5
|
68.4
|
1.0
|
|
C10
|
C:XQ31002
|
3.6
|
68.4
|
1.0
|
|
CZ
|
C:PHE524
|
3.7
|
75.0
|
1.0
|
|
OD1
|
C:ASN474
|
3.7
|
68.0
|
1.0
|
|
C08
|
C:XQ31002
|
3.8
|
68.4
|
1.0
|
|
HE1
|
C:PHE524
|
3.8
|
75.0
|
1.0
|
|
H111
|
C:XQ31002
|
3.9
|
68.4
|
1.0
|
|
CZ
|
C:PHE592
|
3.9
|
71.4
|
1.0
|
|
C11
|
C:XQ31002
|
3.9
|
68.4
|
1.0
|
|
CE1
|
C:PHE524
|
4.0
|
75.0
|
1.0
|
|
C33
|
C:XQ31002
|
4.0
|
68.4
|
1.0
|
|
C39
|
C:XQ31002
|
4.1
|
68.4
|
1.0
|
|
HE1
|
C:PHE592
|
4.3
|
71.4
|
1.0
|
|
H061
|
C:XQ31002
|
4.3
|
68.4
|
1.0
|
|
C15
|
C:XQ31002
|
4.3
|
68.4
|
1.0
|
|
C07
|
C:XQ31002
|
4.4
|
68.4
|
1.0
|
|
C20
|
C:XQ31002
|
4.4
|
68.4
|
1.0
|
|
HD21
|
C:ASN474
|
4.4
|
68.0
|
1.0
|
|
CE2
|
C:PHE524
|
4.5
|
75.0
|
1.0
|
|
N06
|
C:XQ31002
|
4.5
|
68.4
|
1.0
|
|
HD1
|
C:TYR478
|
4.5
|
66.2
|
1.0
|
|
C32
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
CE1
|
C:PHE592
|
4.6
|
71.4
|
1.0
|
|
S16
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
HB2
|
C:TYR478
|
4.6
|
66.2
|
1.0
|
|
H202
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
CG
|
C:ASN474
|
4.6
|
68.0
|
1.0
|
|
H241
|
C:XQ31002
|
4.6
|
68.4
|
1.0
|
|
HE2
|
C:PHE524
|
4.7
|
75.0
|
1.0
|
|
HE2
|
C:TYR591
|
4.8
|
77.3
|
1.0
|
|
H391
|
C:XQ31002
|
4.8
|
68.4
|
1.0
|
|
N19
|
C:XQ31002
|
4.8
|
68.4
|
1.0
|
|
ND2
|
C:ASN474
|
4.9
|
68.0
|
1.0
|
|
HE2
|
C:PHE592
|
4.9
|
71.4
|
1.0
|
|
C12
|
C:XQ31002
|
4.9
|
68.4
|
1.0
|
|
CE2
|
C:PHE592
|
4.9
|
71.4
|
1.0
|
|
CD1
|
C:PHE524
|
5.0
|
75.0
|
1.0
|
|
Chlorine binding site 7 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 7 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl901
b:68.4
occ:1.00
|
CL34
|
D:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C33
|
D:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
D:XQ3901
|
2.8
|
68.4
|
1.0
|
|
C32
|
D:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
D:XQ3901
|
2.8
|
68.4
|
1.0
|
|
HG22
|
D:THR527
|
2.9
|
81.7
|
1.0
|
|
O40
|
D:XQ3901
|
3.0
|
68.4
|
1.0
|
|
O41
|
D:XQ3901
|
3.0
|
68.4
|
1.0
|
|
HD1
|
D:PHE524
|
3.1
|
75.0
|
1.0
|
|
S30
|
D:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HB
|
D:THR527
|
3.3
|
81.7
|
1.0
|
|
HG21
|
D:THR527
|
3.5
|
81.7
|
1.0
|
|
CG2
|
D:THR527
|
3.6
|
81.7
|
1.0
|
|
CD1
|
D:PHE524
|
3.6
|
75.0
|
1.0
|
|
N29
|
D:XQ3901
|
3.7
|
68.4
|
1.0
|
|
OD1
|
D:ASN528
|
3.7
|
83.6
|
1.0
|
|
HA
|
D:PHE524
|
3.8
|
75.0
|
1.0
|
|
C25
|
D:XQ3901
|
3.8
|
68.4
|
1.0
|
|
O
|
D:PHE524
|
3.9
|
75.0
|
1.0
|
|
H291
|
D:XQ3901
|
4.0
|
68.4
|
1.0
|
|
CB
|
D:THR527
|
4.0
|
81.7
|
1.0
|
|
HB2
|
D:ASN528
|
4.0
|
83.6
|
1.0
|
|
HE1
|
D:PHE524
|
4.0
|
75.0
|
1.0
|
|
C36
|
D:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
D:XQ3901
|
4.1
|
68.4
|
1.0
|
|
CE1
|
D:PHE524
|
4.2
|
75.0
|
1.0
|
|
HB3
|
D:TYR553
|
4.2
|
73.5
|
1.0
|
|
CG
|
D:ASN528
|
4.2
|
83.6
|
1.0
|
|
C26
|
D:XQ3901
|
4.3
|
68.4
|
1.0
|
|
HB2
|
D:TYR553
|
4.3
|
73.5
|
1.0
|
|
N
|
D:ASN528
|
4.4
|
83.6
|
1.0
|
|
HG23
|
D:THR527
|
4.4
|
81.7
|
1.0
|
|
HB3
|
D:PHE524
|
4.4
|
75.0
|
1.0
|
|
H
|
D:ASN528
|
4.5
|
83.6
|
1.0
|
|
HA
|
D:ASN528
|
4.5
|
83.6
|
1.0
|
|
CB
|
D:ASN528
|
4.5
|
83.6
|
1.0
|
|
CG
|
D:PHE524
|
4.5
|
75.0
|
1.0
|
|
CA
|
D:PHE524
|
4.5
|
75.0
|
1.0
|
|
H212
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C38
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
O31
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
C
|
D:PHE524
|
4.6
|
75.0
|
1.0
|
|
H261
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CB
|
D:TYR553
|
4.6
|
73.5
|
1.0
|
|
C
|
D:THR527
|
4.7
|
81.7
|
1.0
|
|
CB
|
D:PHE524
|
4.7
|
75.0
|
1.0
|
|
CA
|
D:ASN528
|
4.7
|
83.6
|
1.0
|
|
H391
|
D:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N22
|
D:XQ3901
|
4.8
|
68.4
|
1.0
|
|
CG
|
D:TYR553
|
4.9
|
73.5
|
1.0
|
|
HD2
|
D:TYR553
|
4.9
|
73.5
|
1.0
|
|
CA
|
D:THR527
|
5.0
|
81.7
|
1.0
|
|
H201
|
D:XQ3901
|
5.0
|
68.4
|
1.0
|
|
OG1
|
D:THR527
|
5.0
|
81.7
|
1.0
|
|
ND2
|
D:ASN528
|
5.0
|
83.6
|
1.0
|
|
Chlorine binding site 8 out
of 8 in 8fcb
Go back to
Chlorine Binding Sites List in 8fcb
Chlorine binding site 8 out
of 8 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK1016790A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl901
b:68.4
occ:1.00
|
CL37
|
D:XQ3901
|
0.0
|
68.4
|
1.0
|
|
C36
|
D:XQ3901
|
1.8
|
68.4
|
1.0
|
|
C35
|
D:XQ3901
|
2.7
|
68.4
|
1.0
|
|
C38
|
D:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H351
|
D:XQ3901
|
2.8
|
68.4
|
1.0
|
|
H381
|
D:XQ3901
|
2.9
|
68.4
|
1.0
|
|
HZ
|
D:PHE592
|
3.0
|
71.4
|
1.0
|
|
H091
|
D:XQ3901
|
3.1
|
68.4
|
1.0
|
|
C09
|
D:XQ3901
|
3.2
|
68.4
|
1.0
|
|
HZ
|
D:PHE524
|
3.3
|
75.0
|
1.0
|
|
H201
|
D:XQ3901
|
3.5
|
68.4
|
1.0
|
|
C10
|
D:XQ3901
|
3.6
|
68.4
|
1.0
|
|
CZ
|
D:PHE524
|
3.7
|
75.0
|
1.0
|
|
OD1
|
D:ASN474
|
3.7
|
68.0
|
1.0
|
|
C08
|
D:XQ3901
|
3.8
|
68.4
|
1.0
|
|
HE1
|
D:PHE524
|
3.8
|
75.0
|
1.0
|
|
H111
|
D:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CZ
|
D:PHE592
|
3.9
|
71.4
|
1.0
|
|
C11
|
D:XQ3901
|
3.9
|
68.4
|
1.0
|
|
CE1
|
D:PHE524
|
4.0
|
75.0
|
1.0
|
|
C33
|
D:XQ3901
|
4.0
|
68.4
|
1.0
|
|
C39
|
D:XQ3901
|
4.1
|
68.4
|
1.0
|
|
HE1
|
D:PHE592
|
4.3
|
71.4
|
1.0
|
|
H061
|
D:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C15
|
D:XQ3901
|
4.3
|
68.4
|
1.0
|
|
C07
|
D:XQ3901
|
4.4
|
68.4
|
1.0
|
|
C20
|
D:XQ3901
|
4.4
|
68.4
|
1.0
|
|
HD21
|
D:ASN474
|
4.4
|
68.0
|
1.0
|
|
CE2
|
D:PHE524
|
4.5
|
75.0
|
1.0
|
|
N06
|
D:XQ3901
|
4.5
|
68.4
|
1.0
|
|
HD1
|
D:TYR478
|
4.5
|
66.2
|
1.0
|
|
C32
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CE1
|
D:PHE592
|
4.6
|
71.4
|
1.0
|
|
S16
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HB2
|
D:TYR478
|
4.6
|
66.2
|
1.0
|
|
H202
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
CG
|
D:ASN474
|
4.6
|
68.0
|
1.0
|
|
H241
|
D:XQ3901
|
4.6
|
68.4
|
1.0
|
|
HE2
|
D:PHE524
|
4.7
|
75.0
|
1.0
|
|
HE2
|
D:TYR591
|
4.8
|
77.3
|
1.0
|
|
H391
|
D:XQ3901
|
4.8
|
68.4
|
1.0
|
|
N19
|
D:XQ3901
|
4.8
|
68.4
|
1.0
|
|
ND2
|
D:ASN474
|
4.9
|
68.0
|
1.0
|
|
HE2
|
D:PHE592
|
4.9
|
71.4
|
1.0
|
|
C12
|
D:XQ3901
|
4.9
|
68.4
|
1.0
|
|
CE2
|
D:PHE592
|
4.9
|
71.4
|
1.0
|
|
CD1
|
D:PHE524
|
5.0
|
75.0
|
1.0
|
|
Reference:
D.H.Kwon,
F.Zhang,
B.A.Mccray,
S.Feng,
M.Kumar,
J.M.Sullivan,
W.Im,
C.J.Sumner,
S.Y.Lee.
TRPV4-Rho Gtpase Complex Structures Reveal Mechanisms of Gating and Disease. Nat Commun V. 14 3732 2023.
ISSN: ESSN 2041-1723
PubMed: 37353484
DOI: 10.1038/S41467-023-39345-0
Page generated: Sun Jul 13 11:21:13 2025
|
