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Atomistry » Chlorine » PDB 8fh8-8fpl » 8flh | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 8fh8-8fpl » 8flh » |
Chlorine in PDB 8flh: Bruton'S Tyrosine Kinase in Complex with An Orthosteric InhibitorEnzymatic activity of Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor
All present enzymatic activity of Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor:
2.7.10.2; Protein crystallography data
The structure of Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor, PDB code: 8flh
was solved by
C.M.Metrick,
D.J.Marcotte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor
(pdb code 8flh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor, PDB code: 8flh: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 8flhGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 8flhGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Bruton'S Tyrosine Kinase in Complex with An Orthosteric Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
G.H.Vandeveer,
R.M.Arduini,
D.P.Baker,
K.Barry,
T.Bohnert,
J.K.Bowden-Verhoek,
P.Conlon,
P.F.Cullen,
B.Guan,
T.J.Jenkins,
S.Y.Liao,
L.Lin,
Y.T.Liu,
D.Marcotte,
E.Mertsching,
C.M.Metrick,
E.Negrou,
N.Powell,
D.Scott,
L.F.Silvian,
B.T.Hopkins.
Discovery of Structural Diverse Reversible Btk Inhibitors Utilized to Develop A Novel in Vivo CD69 and CD86 Pk/Pd Mouse Model. Bioorg.Med.Chem.Lett. V. 80 29108 2023.
Page generated: Sun Jul 13 11:29:02 2025
ISSN: ESSN 1464-3405 PubMed: 36538993 DOI: 10.1016/J.BMCL.2022.129108 |
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