Chlorine in PDB 8fq2: Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)

The binding sites of Chlorine atom in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) (pdb code 8fq2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K), PDB code: 8fq2:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:35.1 occ:1.00 CL A:CYZ1302 0.0 35.1 1.0 C13 A:CYZ1302 1.8 35.1 1.0 C12 A:CYZ1302 2.7 35.1 1.0 C14 A:CYZ1302 2.8 35.1 1.0 O4 A:CYZ1302 2.9 35.1 1.0 S2 A:CYZ1302 3.2 35.1 1.0 N A:ASP760 3.4 35.2 1.0 N3 A:CYZ1302 3.5 35.1 1.0 CB A:LEU759 3.6 34.4 1.0 C A:LEU759 3.7 34.4 1.0 CA A:ASP760 3.7 35.2 1.0 O A:PHE495 4.0 32.5 1.0 CB A:ASP760 4.0 35.2 1.0 C11 A:CYZ1302 4.0 35.1 1.0 O A:LEU759 4.1 34.4 1.0 C10 A:CYZ1302 4.1 35.1 1.0 CA A:LEU759 4.2 34.4 1.0 C9 A:CYZ1302 4.6 35.1 1.0 CD1 A:LEU759 4.8 34.4 1.0 CG A:LEU759 4.8 34.4 1.0 CG A:ASP760 4.8 35.2 1.0 O3 A:CYZ1302 4.8 35.1 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:28.1 occ:1.00 CL D:CYZ1302 0.0 28.1 1.0 C13 D:CYZ1302 1.8 28.1 1.0 C12 D:CYZ1302 2.7 28.1 1.0 C14 D:CYZ1302 2.8 28.1 1.0 O4 D:CYZ1302 3.1 28.1 1.0 S2 D:CYZ1302 3.2 28.1 1.0 OD2 D:ASP760 3.2 31.3 1.0 OD1 D:ASP760 3.3 31.3 1.0 CG D:ASP760 3.3 31.3 1.0 N3 D:CYZ1302 3.4 28.1 1.0 CB D:LEU759 3.6 29.5 1.0 N D:ASP760 3.7 31.3 1.0 C D:LEU759 4.0 29.5 1.0 C11 D:CYZ1302 4.0 28.1 1.0 CA D:ASP760 4.1 31.3 1.0 C10 D:CYZ1302 4.1 28.1 1.0 CB D:ASP760 4.3 31.3 1.0 CA D:LEU759 4.5 29.5 1.0 O D:LEU759 4.5 29.5 1.0 C9 D:CYZ1302 4.6 28.1 1.0 CD1 D:LEU759 4.6 29.5 1.0 CG D:LEU759 4.7 29.5 1.0 O D:PHE495 4.8 24.9 1.0 O3 D:CYZ1302 4.8 28.1 1.0 OG A:SER729 4.9 27.5 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:26.0 occ:1.00 CL B:CYZ1302 0.0 26.0 1.0 C13 B:CYZ1302 1.8 26.0 1.0 C12 B:CYZ1302 2.7 26.0 1.0 C14 B:CYZ1302 2.8 26.0 1.0 O4 B:CYZ1302 3.1 26.0 1.0 S2 B:CYZ1302 3.2 26.0 1.0 OD2 B:ASP760 3.2 30.6 1.0 OD1 B:ASP760 3.3 30.6 1.0 CG B:ASP760 3.3 30.6 1.0 N3 B:CYZ1302 3.4 26.0 1.0 CB B:LEU759 3.6 28.9 1.0 N B:ASP760 3.7 30.6 1.0 C B:LEU759 4.0 28.9 1.0 C11 B:CYZ1302 4.0 26.0 1.0 CA B:ASP760 4.1 30.6 1.0 C10 B:CYZ1302 4.1 26.0 1.0 CB B:ASP760 4.3 30.6 1.0 CA B:LEU759 4.5 28.9 1.0 O B:LEU759 4.5 28.9 1.0 C9 B:CYZ1302 4.6 26.0 1.0 CD1 B:LEU759 4.6 28.9 1.0 CG B:LEU759 4.7 28.9 1.0 O B:PHE495 4.8 22.6 1.0 O3 B:CYZ1302 4.8 26.0 1.0 OG C:SER729 4.9 26.3 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:23.5 occ:1.00 CL C:CYZ1302 0.0 23.5 1.0 C13 C:CYZ1302 1.8 23.5 1.0 C12 C:CYZ1302 2.7 23.5 1.0 C14 C:CYZ1302 2.8 23.5 1.0 O4 C:CYZ1302 2.9 23.5 1.0 S2 C:CYZ1302 3.2 23.5 1.0 N C:ASP760 3.4 32.3 1.0 N3 C:CYZ1302 3.5 23.5 1.0 CB C:LEU759 3.6 31.4 1.0 C C:LEU759 3.7 31.4 1.0 CA C:ASP760 3.7 32.3 1.0 O C:PHE495 4.0 24.8 1.0 CB C:ASP760 4.0 32.3 1.0 C11 C:CYZ1302 4.0 23.5 1.0 O C:LEU759 4.1 31.4 1.0 C10 C:CYZ1302 4.1 23.5 1.0 CA C:LEU759 4.2 31.4 1.0 C9 C:CYZ1302 4.6 23.5 1.0 CD1 C:LEU759 4.8 31.4 1.0 CG C:LEU759 4.8 31.4 1.0 CG C:ASP760 4.8 32.3 1.0 O3 C:CYZ1302 4.8 23.5 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3