Chlorine in PDB 8i5g: Structure of Human NAV1.7 in Complex with Pf-05089771

The structure of Structure of Human NAV1.7 in Complex with Pf-05089771 also contains other interesting chemical elements:

Fluorine	(F)	1 atom
Sodium	(Na)	1 atom

The binding sites of Chlorine atom in the Structure of Human NAV1.7 in Complex with Pf-05089771 (pdb code 8i5g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human NAV1.7 in Complex with Pf-05089771, PDB code: 8i5g:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Human NAV1.7 in Complex with Pf-05089771


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human NAV1.7 in Complex with Pf-05089771 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2005 b:73.1 occ:1.00 CL01 A:T702005 0.0 73.1 1.0 C21 A:T702005 1.8 53.8 1.0 C17 A:T702005 2.7 51.1 1.0 C19 A:T702005 2.8 51.2 1.0 O06 A:T702005 3.0 52.5 1.0 CE1 A:PHE1609 3.4 48.5 1.0 CZ A:PHE1609 3.5 49.6 1.0 OE2 A:GLU1600 3.6 79.8 1.0 CE2 A:TYR1548 3.6 44.5 1.0 CD A:GLU1600 3.7 79.4 1.0 N12 A:T702005 3.8 59.4 1.0 CD2 A:TYR1548 3.9 44.9 1.0 N A:ASP1597 4.0 60.9 1.0 C22 A:T702005 4.0 50.6 1.0 CB A:ALA1596 4.0 56.0 1.0 C14 A:T702005 4.0 52.5 1.0 C A:ALA1596 4.0 59.8 1.0 CG A:GLU1600 4.1 75.2 1.0 OE1 A:GLU1600 4.1 78.0 1.0 O A:ALA1596 4.2 63.1 1.0 CA A:ASP1597 4.2 61.3 1.0 CZ A:TYR1548 4.2 48.1 1.0 C16 A:T702005 4.3 53.9 1.0 C20 A:T702005 4.6 51.0 1.0 OH A:TYR1548 4.6 51.3 1.0 CG A:TYR1548 4.7 43.6 1.0 OD1 A:ASP1597 4.7 69.7 1.0 CA A:ALA1596 4.7 55.5 1.0 CD1 A:PHE1609 4.7 50.4 1.0 CB A:ASP1597 4.8 63.4 1.0 C24 A:T702005 4.8 52.7 1.0 CE2 A:PHE1609 4.8 51.3 1.0 O A:MET1593 4.9 60.3 1.0 CB A:GLU1600 4.9 72.1 1.0 CE1 A:TYR1548 5.0 48.2 1.0 C25 A:T702005 5.0 55.7 1.0

Chlorine binding site 2 out of 2 in the Structure of Human NAV1.7 in Complex with Pf-05089771


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human NAV1.7 in Complex with Pf-05089771 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2005 b:70.4 occ:1.00 CL02 A:T702005 0.0 70.4 1.0 C27 A:T702005 1.8 56.1 1.0 C23 A:T702005 2.7 55.1 1.0 C28 A:T702005 2.8 54.4 1.0 C15 A:T702005 4.0 52.0 1.0 C25 A:T702005 4.0 55.7 1.0 CH2 A:TRP1549 4.1 49.2 1.0 CZ3 A:TRP1549 4.1 45.2 1.0 CE1 A:PHE1594 4.4 60.4 1.0 C16 A:T702005 4.6 53.9 1.0 CG2 A:VAL1552 4.6 44.0 1.0 CG1 A:VAL1552 4.6 42.5 1.0 CE A:MET1593 4.9 55.4 1.0 CZ2 A:TRP1549 5.0 46.0 1.0

Q.Wu, J.Huang, X.Fan, K.Wang, X.Jin, G.Huang, J.Li, X.Pan, N.Yan. Structural Mapping of Na V 1.7 Antagonists. Nat Commun V. 14 3224 2023.
ISSN: ESSN 2041-1723
PubMed: 37270609
DOI: 10.1038/S41467-023-38942-3