Chlorine in PDB 8k6l: Cryo-Em Structure of Human OATP1B1 in Complex with Dcf

The binding sites of Chlorine atom in the Cryo-Em Structure of Human OATP1B1 in Complex with Dcf (pdb code 8k6l). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human OATP1B1 in Complex with Dcf, PDB code: 8k6l:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human OATP1B1 in Complex with Dcf


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human OATP1B1 in Complex with Dcf within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl801 b:0.0 occ:1.00 CL24 A:IOQ801 0.0 0.0 1.0 C21 A:IOQ801 1.7 0.0 1.0 C22 A:IOQ801 2.7 0.0 1.0 C20 A:IOQ801 2.7 0.0 1.0 O25 A:IOQ801 3.0 0.0 1.0 N A:PHE356 3.4 42.8 1.0 CB A:ALA355 3.5 39.5 1.0 CA A:PHE356 3.6 42.8 1.0 CB A:PHE356 3.7 42.8 1.0 C A:ALA355 3.7 39.5 1.0 C19 A:IOQ801 4.0 0.0 1.0 C23 A:IOQ801 4.0 0.0 1.0 O A:TYR352 4.1 41.9 1.0 O A:ALA355 4.2 39.5 1.0 CA A:ALA355 4.3 39.5 1.0 CD1 A:PHE356 4.4 42.8 1.0 NE2 A:GLN541 4.4 43.9 1.0 CG A:PHE356 4.5 42.8 1.0 C18 A:IOQ801 4.6 0.0 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human OATP1B1 in Complex with Dcf


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human OATP1B1 in Complex with Dcf within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl801 b:0.0 occ:1.00 CL27 A:IOQ801 0.0 0.0 1.0 C13 A:IOQ801 1.7 0.0 1.0 C12 A:IOQ801 2.7 0.0 1.0 C14 A:IOQ801 2.7 0.0 1.0 O26 A:IOQ801 3.0 0.0 1.0 C11 A:IOQ801 4.0 0.0 1.0 C15 A:IOQ801 4.0 0.0 1.0 C16 A:IOQ801 4.5 0.0 1.0 CZ A:PHE386 4.9 53.1 1.0

Z.Shan, X.Yang, H.Liu, Y.Yuan, Y.Xiao, J.Nan, W.Zhang, W.Song, J.Wang, F.Wei, Y.Zhang. Cryo-Em Structures of Human Organic Anion Transporting Polypeptide OATP1B1. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37674011
DOI: 10.1038/S41422-023-00870-8