Chlorine in PDB 8p8b: Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells

All present enzymatic activity of Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells:
5.2.1.8;

The structure of Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells also contains other interesting chemical elements:

Potassium	(K)	1 atom
Zinc	(Zn)	4 atoms
Magnesium	(Mg)	229 atoms

The binding sites of Chlorine atom in the Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells (pdb code 8p8b). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells, PDB code: 8p8b:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells within 5.0Å range: probe atom residue distance (Å) B Occ 3:Cl3001 b:66.8 occ:1.00 CL1 3:CLM3001 0.0 66.8 1.0 C1 3:CLM3001 1.8 43.8 1.0 C2 3:CLM3001 2.6 38.0 1.0 CL2 3:CLM3001 2.9 60.4 1.0 N Z:ALA35 3.0 0.0 1.0 CB Z:ALA35 3.0 0.0 1.0 O2 3:CLM3001 3.1 51.0 1.0 O Z:LYS33 3.4 11.5 1.0 N2 3:CLM3001 3.6 35.8 1.0 CA Z:ALA35 3.6 0.0 1.0 C Z:ALA34 3.7 0.0 1.0 C Z:LYS33 3.7 3.4 1.0 CA Z:ALA34 3.9 0.0 1.0 N Z:ALA34 4.0 0.0 1.0 N1 3:A2069 4.0 45.9 1.0 N6 3:A2069 4.2 43.3 1.0 CG Z:LYS33 4.3 2.1 1.0 C6 3:A2069 4.6 44.5 1.0 CA Z:LYS33 4.7 0.0 1.0 O2' 3:G2513 4.7 35.7 1.0 O Z:ALA34 4.7 10.5 1.0 C Z:ALA35 4.8 0.0 1.0 C3 3:CLM3001 4.9 32.2 1.0 CB Z:LYS33 4.9 0.0 1.0 C1' 3:G2513 5.0 35.5 1.0

Chlorine binding site 2 out of 2 in the Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Mycoplasma Pneumoniae Large Ribosomal Subunit in Chloramphenicol- Treated Cells within 5.0Å range: probe atom residue distance (Å) B Occ 3:Cl3001 b:60.4 occ:1.00 CL2 3:CLM3001 0.0 60.4 1.0 C1 3:CLM3001 1.8 43.8 1.0 C2 3:CLM3001 2.6 38.0 1.0 CL1 3:CLM3001 2.9 66.8 1.0 O2 3:CLM3001 3.0 51.0 1.0 CG Z:LYS33 3.3 2.1 1.0 CE Z:LYS33 3.6 10.6 1.0 N2 3:CLM3001 3.7 35.8 1.0 O4' 3:G2513 3.7 44.6 1.0 O Z:LYS33 3.9 11.5 1.0 CD Z:LYS33 3.9 5.2 1.0 C1' 3:G2513 4.2 35.5 1.0 OP2 3:G2513 4.3 35.9 1.0 CB Z:LYS33 4.4 0.0 1.0 C8 3:2MA2511 4.5 26.2 1.0 N6 3:A2069 4.6 43.3 1.0 C4' 3:G2513 4.7 38.7 1.0 C Z:LYS33 4.7 3.4 1.0 N7 3:2MA2511 4.7 25.1 1.0 O5' 3:G2513 4.8 42.5 1.0 C3 3:CLM3001 4.8 32.2 1.0 C4 3:CLM3001 4.9 40.2 1.0 NZ Z:LYS33 5.0 2.5 1.0

L.Xue, C.M.T.Spahn, M.Schacherl, J.Mahamid. Structural Insights Into Context-Dependent Inhibitory Mechanisms of Chloramphenicol in Cells Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01441-0