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Chlorine in PDB 8zbu: Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib)

Enzymatic activity of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib)

All present enzymatic activity of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib):
7.6.2.2; 7.6.2.3;

Other elements in 8zbu:

The structure of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib) also contains other interesting chemical elements:

Fluorine (F) 1 atom
Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib) (pdb code 8zbu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib), PDB code: 8zbu:

Chlorine binding site 1 out of 1 in 8zbu

Go back to Chlorine Binding Sites List in 8zbu
Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with Lapatinib) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1401

b:75.8
occ:1.00
CL3 A:FMM1401 0.0 75.8 1.0
C36 A:FMM1401 1.7 58.8 1.0
C38 A:FMM1401 2.7 49.6 1.0
C26 A:FMM1401 2.7 59.9 1.0
O27 A:FMM1401 2.9 63.3 1.0
C28 A:FMM1401 3.2 63.4 1.0
C23 A:FMM1401 4.0 51.3 1.0
C25 A:FMM1401 4.0 58.9 1.0
CZ A:PHE368 4.2 43.4 1.0
C29 A:FMM1401 4.4 61.5 1.0
C24 A:FMM1401 4.5 61.4 1.0
C35 A:FMM1401 4.6 59.7 1.0
CE2 A:PHE368 4.6 45.0 1.0
CE1 A:PHE368 4.7 49.5 1.0
CE1 A:HIS152 4.8 62.9 1.0
CE1 A:PHE156 4.8 81.5 1.0
NE2 A:HIS152 4.8 65.5 1.0
CE1 A:PHE211 4.9 54.6 1.0

Reference:

Z.Xie, J.Lv, W.Huang, Z.Wu, R.Zhu, Z.Deng, F.Long. Structural Basis For the Reversal of Human MRP4-Mediated Multidrug Resistance By Lapatinib. Cell Rep V. 44 15466 2025.
ISSN: ESSN 2211-1247
PubMed: 40138312
DOI: 10.1016/J.CELREP.2025.115466
Page generated: Sun Jul 13 15:51:16 2025

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