Chlorine in PDB 8zpb: Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom

The structure of Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom (pdb code 8zpb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom, PDB code: 8zpb:

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Norepinephrine Transporter Net Bound with Norepinephrine in An Occluded State at A Resolution of 2.6 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl704 b:29.4 occ:1.00 HG A:SER354 2.0 26.0 1.0 HG A:SER318 2.1 25.3 1.0 HE21 A:GLN314 2.3 23.2 1.0 HH A:TYR98 2.5 25.0 1.0 OG A:SER354 2.6 25.3 1.0 OG A:SER318 2.9 30.6 1.0 HB2 A:PHE82 2.9 23.9 1.0 NE2 A:GLN314 3.1 19.1 1.0 HB2 A:SER318 3.1 24.3 1.0 HA A:ASN78 3.1 24.5 1.0 OH A:TYR98 3.1 32.6 1.0 HB3 A:SER318 3.2 23.5 1.0 HG3 A:GLN314 3.2 22.7 1.0 CB A:SER318 3.2 21.2 1.0 HE2 A:TYR98 3.3 24.2 1.0 HD22 A:ASN350 3.4 26.1 1.0 HD1 A:PHE82 3.5 22.8 1.0 HE22 A:GLN314 3.5 23.0 1.0 HB3 A:SER354 3.6 25.5 1.0 CB A:SER354 3.6 17.8 1.0 CB A:PHE82 3.8 21.9 1.0 CE2 A:TYR98 3.8 21.3 1.0 CG A:GLN314 3.9 17.7 1.0 CZ A:TYR98 3.9 23.2 1.0 CD A:GLN314 3.9 16.4 1.0 CD1 A:PHE82 3.9 17.4 1.0 HG2 A:GLN314 4.0 23.5 1.0 CA A:ASN78 4.0 23.2 1.0 HB2 A:SER354 4.1 24.3 1.0 CG A:ASN78 4.1 17.4 1.0 HB3 A:PHE82 4.1 23.9 1.0 ND2 A:ASN350 4.1 31.4 1.0 CG A:PHE82 4.2 19.0 1.0 ND2 A:ASN78 4.2 25.8 1.0 OD1 A:ASN78 4.2 15.6 1.0 HD22 A:ASN78 4.4 24.9 1.0 N A:ASN78 4.5 28.0 1.0 HD21 A:ASN78 4.5 25.8 1.0 CB A:ASN78 4.5 27.2 1.0 HD21 A:ASN350 4.5 25.8 1.0 HB3 A:ASN78 4.6 25.4 1.0 O A:GLN314 4.6 18.7 1.0 HA A:SER354 4.7 24.8 1.0 NA A:NA702 4.7 34.3 1.0 CA A:SER318 4.7 22.9 1.0 HB1 A:ALA77 4.7 24.5 1.0 C A:ALA77 4.8 23.5 1.0 CA A:SER354 4.8 20.8 1.0 HB3 A:ALA77 4.8 23.9 1.0 OD1 A:ASN350 4.8 18.6 1.0 O A:ALA77 4.8 24.0 1.0 H A:ASN78 4.8 25.5 1.0 CG A:ASN350 4.9 31.4 1.0 CE1 A:PHE82 4.9 17.3 1.0 HA A:PHE82 4.9 24.0 1.0 CA A:PHE82 4.9 23.0 1.0

A.Song, X.Wu. Mechanistic Insights of Substrate Transport and Inhibitor Binding Revealed By High-Resolution Structures of Human Norepinephrine Transporter Cell Res. 2024.
ISSN: ISSN 1001-0602
DOI: 10.1038/S41422-024-01024-0