Chlorine in PDB 9ce8: 20S Proteasome Core Particle in Complex with Ixazomib

All present enzymatic activity of 20S Proteasome Core Particle in Complex with Ixazomib:
3.4.25.1;

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Chlorine atom in the 20S Proteasome Core Particle in Complex with Ixazomib (pdb code 9ce8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 28 binding sites of Chlorine where determined in the 20S Proteasome Core Particle in Complex with Ixazomib, PDB code: 9ce8:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ O:Cl301 b:76.8 occ:1.00 CL3 O:6V8301 0.0 76.8 1.0 C3 O:6V8301 1.7 51.3 1.0 C4 O:6V8301 2.7 49.4 1.0 C2 O:6V8301 2.7 47.9 1.0 C7 O:6V8301 3.1 48.7 1.0 O8 O:6V8301 3.3 47.7 1.0 N9 O:6V8301 3.8 44.5 1.0 C5 O:6V8301 4.0 53.9 1.0 C1 O:6V8301 4.0 49.1 1.0 C6 O:6V8301 4.5 56.7 1.0 CG O:GLN22 4.6 52.0 1.0 C10 O:6V8301 4.8 37.1 1.0

Chlorine binding site 2 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ O:Cl301 b:82.7 occ:1.00 CL6 O:6V8301 0.0 82.7 1.0 C6 O:6V8301 1.7 56.7 1.0 C1 O:6V8301 2.7 49.1 1.0 C5 O:6V8301 2.7 53.9 1.0 CB O:SER27 3.6 33.2 1.0 C4 O:6V8301 4.0 49.4 1.0 C2 O:6V8301 4.0 47.9 1.0 OG O:SER20 4.1 43.7 1.0 OG O:SER27 4.2 42.6 1.0 C3 O:6V8301 4.5 51.3 1.0 OE1 O:GLN22 4.8 59.1 1.0 CA O:SER27 5.0 32.5 1.0

Chlorine binding site 3 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl301 b:76.8 occ:1.00 CL3 P:6V8301 0.0 76.8 1.0 C3 P:6V8301 1.7 51.3 1.0 C4 P:6V8301 2.7 49.4 1.0 C2 P:6V8301 2.7 47.9 1.0 C7 P:6V8301 3.1 48.7 1.0 O8 P:6V8301 3.3 47.7 1.0 N9 P:6V8301 3.8 44.5 1.0 C5 P:6V8301 4.0 53.9 1.0 C1 P:6V8301 4.0 49.1 1.0 C6 P:6V8301 4.5 56.7 1.0 CG P:GLN22 4.6 52.0 1.0 C10 P:6V8301 4.8 37.1 1.0

Chlorine binding site 4 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl301 b:82.7 occ:1.00 CL6 P:6V8301 0.0 82.7 1.0 C6 P:6V8301 1.7 56.7 1.0 C1 P:6V8301 2.7 49.1 1.0 C5 P:6V8301 2.7 53.9 1.0 CB P:SER27 3.6 33.2 1.0 C4 P:6V8301 4.0 49.4 1.0 C2 P:6V8301 4.0 47.9 1.0 OG P:SER20 4.1 43.7 1.0 OG P:SER27 4.2 42.6 1.0 C3 P:6V8301 4.5 51.3 1.0 OE1 P:GLN22 4.8 59.1 1.0 CA P:SER27 5.0 32.5 1.0

Chlorine binding site 5 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ Q:Cl301 b:76.8 occ:1.00 CL3 Q:6V8301 0.0 76.8 1.0 C3 Q:6V8301 1.7 51.3 1.0 C4 Q:6V8301 2.7 49.4 1.0 C2 Q:6V8301 2.7 47.9 1.0 C7 Q:6V8301 3.1 48.7 1.0 O8 Q:6V8301 3.3 47.7 1.0 N9 Q:6V8301 3.8 44.5 1.0 C5 Q:6V8301 4.0 53.9 1.0 C1 Q:6V8301 4.0 49.1 1.0 C6 Q:6V8301 4.5 56.7 1.0 CG Q:GLN22 4.6 52.0 1.0 C10 Q:6V8301 4.8 37.1 1.0

Chlorine binding site 6 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ Q:Cl301 b:82.7 occ:1.00 CL6 Q:6V8301 0.0 82.7 1.0 C6 Q:6V8301 1.7 56.7 1.0 C1 Q:6V8301 2.7 49.1 1.0 C5 Q:6V8301 2.7 53.9 1.0 CB Q:SER27 3.6 33.2 1.0 C4 Q:6V8301 4.0 49.4 1.0 C2 Q:6V8301 4.0 47.9 1.0 OG Q:SER20 4.1 43.7 1.0 OG Q:SER27 4.2 42.6 1.0 C3 Q:6V8301 4.5 51.3 1.0 OE1 Q:GLN22 4.8 59.1 1.0 CA Q:SER27 5.0 32.5 1.0

Chlorine binding site 7 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl301 b:76.8 occ:1.00 CL3 R:6V8301 0.0 76.8 1.0 C3 R:6V8301 1.7 51.3 1.0 C4 R:6V8301 2.7 49.4 1.0 C2 R:6V8301 2.7 47.9 1.0 C7 R:6V8301 3.1 48.7 1.0 O8 R:6V8301 3.3 47.7 1.0 N9 R:6V8301 3.8 44.5 1.0 C5 R:6V8301 4.0 53.9 1.0 C1 R:6V8301 4.0 49.1 1.0 C6 R:6V8301 4.5 56.7 1.0 CG R:GLN22 4.6 52.0 1.0 C10 R:6V8301 4.8 37.1 1.0

Chlorine binding site 8 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl301 b:82.7 occ:1.00 CL6 R:6V8301 0.0 82.7 1.0 C6 R:6V8301 1.7 56.7 1.0 C1 R:6V8301 2.7 49.1 1.0 C5 R:6V8301 2.7 53.9 1.0 CB R:SER27 3.6 33.2 1.0 C4 R:6V8301 4.0 49.4 1.0 C2 R:6V8301 4.0 47.9 1.0 OG R:SER20 4.1 43.7 1.0 OG R:SER27 4.2 42.6 1.0 C3 R:6V8301 4.5 51.3 1.0 OE1 R:GLN22 4.8 59.1 1.0 CA R:SER27 5.0 32.5 1.0

Chlorine binding site 9 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ S:Cl301 b:76.8 occ:1.00 CL3 S:6V8301 0.0 76.8 1.0 C3 S:6V8301 1.7 51.3 1.0 C4 S:6V8301 2.7 49.4 1.0 C2 S:6V8301 2.7 47.9 1.0 C7 S:6V8301 3.1 48.7 1.0 O8 S:6V8301 3.3 47.7 1.0 N9 S:6V8301 3.8 44.5 1.0 C5 S:6V8301 4.0 53.9 1.0 C1 S:6V8301 4.0 49.1 1.0 C6 S:6V8301 4.5 56.7 1.0 CG S:GLN22 4.6 52.0 1.0 C10 S:6V8301 4.8 37.1 1.0

Chlorine binding site 10 out of 28 in the 20S Proteasome Core Particle in Complex with Ixazomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of 20S Proteasome Core Particle in Complex with Ixazomib within 5.0Å range: probe atom residue distance (Å) B Occ S:Cl301 b:82.7 occ:1.00 CL6 S:6V8301 0.0 82.7 1.0 C6 S:6V8301 1.7 56.7 1.0 C1 S:6V8301 2.7 49.1 1.0 C5 S:6V8301 2.7 53.9 1.0 CB S:SER27 3.6 33.2 1.0 C4 S:6V8301 4.0 49.4 1.0 C2 S:6V8301 4.0 47.9 1.0 OG S:SER20 4.1 43.7 1.0 OG S:SER27 4.2 42.6 1.0 C3 S:6V8301 4.5 51.3 1.0 OE1 S:GLN22 4.8 59.1 1.0 CA S:SER27 5.0 32.5 1.0

M.Turner, A.B.Uday, A.Velyvis, E.Rennella, N.Zeytuni, S.Vahidi. Structural Basis For Allosteric Modulation of M. Tuberculosis Proteasome Core Particle To Be Published.