Chlorine in PDB 9fgh: Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State

The binding sites of Chlorine atom in the Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State (pdb code 9fgh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State, PDB code: 9fgh:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:69.6 occ:1.00 N A:ASN189 3.2 59.7 1.0 N A:VAL53 3.3 59.8 1.0 N A:GLN190 3.6 67.5 1.0 CD2 A:TYR191 3.7 62.5 1.0 CD2 A:LEU188 3.8 57.0 1.0 CA A:PRO52 3.9 53.0 1.0 CA A:LEU188 3.9 59.2 1.0 CG A:GLN190 4.0 68.9 1.0 O A:VAL53 4.0 69.9 1.0 C A:LEU188 4.1 60.5 1.0 CA A:ASN189 4.1 60.0 1.0 CB A:VAL53 4.1 57.5 1.0 CB A:ASN189 4.1 61.5 1.0 C A:PRO52 4.2 55.0 1.0 CA A:VAL53 4.2 57.8 1.0 CB A:PRO52 4.3 49.8 1.0 C A:ASN189 4.3 64.2 1.0 N A:TYR191 4.4 57.7 1.0 CB A:LEU188 4.4 60.5 1.0 CG2 A:VAL53 4.5 53.3 1.0 CE2 A:TYR191 4.5 60.9 1.0 CB A:TYR191 4.6 56.2 1.0 CG A:TYR191 4.6 61.6 1.0 C A:VAL53 4.6 59.8 1.0 CA A:GLN190 4.6 63.8 1.0 O A:ARG187 4.6 63.0 1.0 C A:GLN190 4.7 59.4 1.0 CG A:LEU188 4.8 52.4 1.0 CG A:ASN189 4.8 67.5 1.0 ND2 A:ASN189 4.8 59.8 1.0 CB A:GLN190 4.9 64.3 1.0

Chlorine binding site 2 out of 3 in the Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl502 b:95.6 occ:1.00 N C:TYR199 3.3 86.4 1.0 N C:VAL65 3.5 73.2 1.0 N C:GLN200 3.6 91.4 1.0 O C:ARG197 3.7 79.0 1.0 CA C:PRO64 3.9 65.9 1.0 OE1 C:GLN200 4.0 95.1 1.0 CD2 C:TYR199 4.0 87.5 1.0 CA C:LEU198 4.1 70.7 1.0 CA C:TYR199 4.1 86.6 1.0 C C:LEU198 4.2 76.3 1.0 CB C:TYR199 4.2 84.5 1.0 C C:PRO64 4.2 69.6 1.0 CB C:PRO64 4.3 67.8 1.0 C C:TYR199 4.3 88.3 1.0 CB C:GLN200 4.4 91.7 1.0 CG C:TYR199 4.4 88.1 1.0 CB C:VAL65 4.4 68.0 1.0 CA C:VAL65 4.5 68.2 1.0 CA C:GLN200 4.5 90.6 1.0 O C:VAL65 4.5 76.0 1.0 CD1 C:PHE201 4.5 80.8 1.0 CD2 C:LEU198 4.5 70.9 1.0 N C:PHE201 4.6 85.0 1.0 CG2 C:VAL65 4.6 65.1 1.0 C C:ARG197 4.7 71.5 1.0 CG C:GLN200 4.7 91.2 1.0 CD C:GLN200 4.8 96.6 1.0 N C:LEU198 4.9 67.7 1.0 C C:VAL65 4.9 72.8 1.0 CE2 C:TYR199 4.9 87.6 1.0 C C:GLN200 5.0 93.7 1.0

Chlorine binding site 3 out of 3 in the Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long- Lived Symmetric Desensitised State within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl502 b:76.5 occ:1.00 N D:ASN189 2.9 65.7 1.0 N D:VAL53 3.5 62.8 1.0 CA D:LEU188 3.6 58.2 1.0 CA D:PRO52 3.7 52.6 1.0 C D:LEU188 3.8 58.0 1.0 N D:GLN190 3.8 69.0 1.0 CA D:ASN189 3.9 65.9 1.0 CB D:ASN189 3.9 67.7 1.0 CB D:PRO52 3.9 51.6 1.0 CD2 D:LEU188 4.1 57.4 1.0 C D:PRO52 4.2 59.9 1.0 CB D:LEU188 4.2 61.3 1.0 CG D:GLN190 4.2 70.2 1.0 CD2 D:TYR191 4.3 66.3 1.0 O D:VAL53 4.3 69.0 1.0 C D:ASN189 4.3 67.9 1.0 ND2 D:ASN189 4.4 68.0 1.0 CG D:ASN189 4.4 73.0 1.0 O D:ARG187 4.5 56.7 1.0 CA D:VAL53 4.5 57.7 1.0 CB D:VAL53 4.6 54.7 1.0 N D:TYR191 4.7 61.6 1.0 CG D:LEU188 4.8 55.9 1.0 N D:LEU188 4.8 56.8 1.0 CA D:GLN190 4.8 66.8 1.0 C D:VAL53 4.9 59.7 1.0 CG2 D:VAL53 5.0 54.4 1.0 O D:LEU188 5.0 56.6 1.0 CE2 D:TYR191 5.0 63.0 1.0 N D:PRO52 5.0 51.6 1.0

D.B.Mihaylov, T.Malinauskas, A.R.Aricescu. Cryo-Em Structure of the Full-Length ALPHA1BETA3GAMMA2 Gaba(A) Receptor in Large MSP2N2 Nanodisc in Complex with Gaba in the Long-Lived Symmetric Desensitised State To Be Published.