Chlorine in PDB 9g6d: CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.

The binding sites of Chlorine atom in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. (pdb code 9g6d). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid., PDB code: 9g6d:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:173.9 occ:1.00 N A:GLY248 2.9 117.8 1.0 N A:PHE514 3.3 113.9 1.0 N A:ILE515 3.3 110.9 1.0 CB A:PHE514 3.5 116.1 1.0 O A:GLY245 3.6 118.6 1.0 N A:GLU247 3.6 125.1 1.0 CA A:GLY248 3.6 117.3 1.0 C A:GLY245 3.6 115.8 1.0 CG1 A:ILE515 3.8 109.4 1.0 CA A:PHE514 3.8 112.1 1.0 CA A:GLY245 3.8 114.3 1.0 C A:GLY512 3.8 119.3 1.0 N A:VAL513 3.8 115.0 1.0 CA A:GLY512 3.8 117.3 1.0 C A:GLU247 3.8 123.0 1.0 CB A:GLU247 3.8 120.9 1.0 CA A:GLU247 4.0 121.6 1.0 C A:PHE514 4.0 115.7 1.0 CB A:ILE515 4.1 107.9 1.0 C A:VAL513 4.2 110.4 1.0 N A:LYS246 4.3 108.8 1.0 CL A:CL902 4.3 173.2 1.0 CG A:PHE514 4.3 117.6 1.0 CA A:ILE515 4.3 108.9 1.0 O A:GLY512 4.4 121.2 1.0 N A:GLY245 4.4 113.5 1.0 OE1 A:GLU247 4.5 130.4 1.0 CD2 A:PHE514 4.5 118.4 1.0 C A:LYS246 4.5 111.0 1.0 CA A:VAL513 4.5 112.9 1.0 CD A:PRO516 4.6 91.5 1.0 N A:GLY512 4.6 116.7 1.0 CD A:PRO249 4.7 115.0 1.0 CD1 A:ILE515 4.7 105.7 1.0 CA A:LYS246 4.9 107.9 1.0 O A:GLU247 5.0 128.3 1.0 C A:GLY248 5.0 121.8 1.0

Chlorine binding site 2 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:173.2 occ:1.00 OH A:TYR602 2.4 131.0 0.5 N A:VAL513 2.9 115.0 1.0 CB A:SER204 3.4 117.2 1.0 N A:PHE514 3.5 113.9 1.0 CG A:PHE514 3.5 117.6 1.0 CA A:GLY512 3.5 117.3 1.0 CD1 A:PHE514 3.6 120.2 1.0 OG A:SER204 3.6 118.3 1.0 CD2 A:PHE514 3.6 118.4 1.0 CE1 A:PHE514 3.7 119.6 1.0 CA A:GLY248 3.7 117.3 1.0 C A:GLY512 3.7 119.3 1.0 CZ A:TYR602 3.8 131.1 0.5 CE2 A:PHE514 3.8 119.0 1.0 CZ A:PHE514 3.8 117.5 1.0 CG1 A:VAL513 3.9 115.9 1.0 CA A:VAL513 3.9 112.9 1.0 C A:VAL513 4.1 110.4 1.0 CB A:PHE514 4.2 116.1 1.0 CB A:VAL513 4.3 112.4 1.0 CL A:CL901 4.3 173.9 1.0 CA A:PHE514 4.4 112.1 1.0 CE1 A:TYR602 4.5 130.0 0.5 C A:GLY248 4.6 121.8 1.0 N A:GLY248 4.7 117.8 1.0 CE2 A:TYR602 4.7 131.5 0.5 CA A:SER204 4.9 113.5 1.0 N A:GLY512 4.9 116.7 1.0 O A:GLY512 4.9 121.2 1.0 CG1 A:ILE206 5.0 112.7 1.0

Chlorine binding site 3 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:168.6 occ:1.00 NE2 A:GLN208 2.8 121.8 1.0 O A:ALA202 3.4 114.3 1.0 OE1 A:GLN208 3.5 118.0 1.0 CD A:GLN208 3.5 119.2 1.0 N A:GLY205 3.6 106.0 1.0 CD A:PRO207 3.7 116.6 1.0 CA A:GLY205 3.9 103.5 1.0 CG A:PRO207 4.0 120.4 1.0 CA A:GLY203 4.1 105.3 1.0 N A:SER204 4.2 114.5 1.0 C A:GLY203 4.3 107.8 1.0 C A:ALA202 4.4 115.2 1.0 CB A:PRO207 4.5 116.4 1.0 C A:GLY205 4.5 109.5 1.0 N A:PRO207 4.7 115.9 1.0 N A:ILE206 4.7 118.2 1.0 N A:GLY203 4.7 108.7 1.0 C A:SER204 4.8 114.2 1.0 N A:GLN208 4.9 117.5 1.0 CG A:GLN208 4.9 117.3 1.0 OG A:SER204 5.0 118.3 1.0

Chlorine binding site 4 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl901 b:179.9 occ:1.00 N C:GLY248 3.0 126.0 1.0 N C:PHE514 3.3 114.2 1.0 N C:ILE515 3.3 109.0 1.0 CB C:PHE514 3.5 116.1 1.0 O C:GLY245 3.6 115.8 1.0 N C:GLU247 3.7 127.7 1.0 C C:GLY245 3.7 112.9 1.0 CA C:GLY248 3.7 124.6 1.0 N C:VAL513 3.8 114.7 1.0 CA C:GLY245 3.8 110.0 1.0 CA C:PHE514 3.8 113.0 1.0 CG1 C:ILE515 3.8 111.0 1.0 CA C:GLY512 3.8 112.9 1.0 CB C:GLU247 3.9 123.6 1.0 C C:GLY512 3.9 114.7 1.0 C C:GLU247 3.9 126.4 1.0 CA C:GLU247 4.0 123.5 1.0 CL C:CL902 4.0 178.0 1.0 C C:PHE514 4.0 115.9 1.0 CB C:ILE515 4.1 108.7 1.0 C C:VAL513 4.2 112.9 1.0 CG C:PHE514 4.3 117.0 1.0 CA C:ILE515 4.3 109.2 1.0 N C:LYS246 4.3 110.6 1.0 N C:GLY245 4.4 110.6 1.0 OE1 C:GLU247 4.5 131.8 1.0 CD2 C:PHE514 4.5 118.5 1.0 CA C:VAL513 4.5 113.5 1.0 O C:GLY512 4.5 116.9 1.0 C C:LYS246 4.6 112.6 1.0 CD C:PRO516 4.6 92.3 1.0 N C:GLY512 4.6 114.8 1.0 CD1 C:ILE515 4.7 107.0 1.0 CD C:PRO249 4.8 117.9 1.0 O C:GLU247 5.0 132.2 1.0 CA C:LYS246 5.0 109.7 1.0

Chlorine binding site 5 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:178.0 occ:1.00 OH C:TYR602 2.4 133.0 0.5 N C:VAL513 3.0 114.7 1.0 CG C:PHE514 3.4 117.0 1.0 CD2 C:PHE514 3.4 118.5 1.0 CA C:GLY248 3.4 124.6 1.0 N C:PHE514 3.5 114.2 1.0 CD1 C:PHE514 3.5 118.2 1.0 CA C:GLY512 3.5 112.9 1.0 CE2 C:PHE514 3.6 120.2 1.0 CB C:SER204 3.6 113.0 1.0 CE1 C:PHE514 3.7 116.8 1.0 CZ C:PHE514 3.7 117.7 1.0 CZ C:TYR602 3.7 133.1 0.5 C C:GLY512 3.8 114.7 1.0 OG C:SER204 3.9 114.9 1.0 CA C:VAL513 4.0 113.5 1.0 CL C:CL901 4.0 179.9 1.0 CG1 C:VAL513 4.1 115.5 1.0 CB C:PHE514 4.1 116.1 1.0 C C:VAL513 4.1 112.9 1.0 CD1 C:ILE206 4.2 117.3 1.0 N C:GLY248 4.3 126.0 1.0 CA C:PHE514 4.4 113.0 1.0 C C:GLY248 4.4 129.5 1.0 CE2 C:TYR602 4.4 133.1 0.5 CB C:VAL513 4.5 112.4 1.0 CE1 C:TYR602 4.6 133.2 0.5 O C:GLY248 4.9 129.9 1.0 N C:GLY512 4.9 114.8 1.0 O C:GLY512 5.0 116.9 1.0

Chlorine binding site 6 out of 6 in the CLC7/OSTM1 Complex in the Absence of PIP2 Lipid.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of CLC7/OSTM1 Complex in the Absence of PIP2 Lipid. within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl903 b:182.5 occ:1.00 OE1 C:GLN208 3.0 121.3 1.0 N C:GLY205 3.6 105.3 1.0 O C:ALA202 3.6 113.6 1.0 CD C:PRO207 3.7 114.3 1.0 CD C:GLN208 3.8 115.7 1.0 NE2 C:GLN208 3.9 114.5 1.0 CA C:GLY203 3.9 106.0 1.0 CG C:PRO207 4.0 117.5 1.0 CA C:GLY205 4.0 103.0 1.0 N C:SER204 4.1 109.7 1.0 C C:GLY203 4.2 106.9 1.0 C C:ALA202 4.5 112.9 1.0 CB C:PRO207 4.5 113.8 1.0 C C:GLY205 4.6 107.3 1.0 OG C:SER204 4.7 114.9 1.0 C C:SER204 4.7 110.2 1.0 N C:GLY203 4.7 108.2 1.0 N C:ILE206 4.7 116.3 1.0 N C:PRO207 4.7 113.4 1.0 OH C:TYR505 4.9 126.1 1.0 CA C:SER204 4.9 109.2 1.0

J.Hilton, Y.Lin, E.Sefah, J.C.Deme, J.Parker, M.J.Langton, M.Grabe, S.Lea, S.Newstead, J.A.Mindell. Mechanism of Phosphoinositide Regulation of Lysosomal pH Via Inhibition of CLC7 To Be Published.