Chlorine in PDB 9g6e: CLC7(Y715C)/OSTM1 Complex

The binding sites of Chlorine atom in the CLC7(Y715C)/OSTM1 Complex (pdb code 9g6e). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the CLC7(Y715C)/OSTM1 Complex, PDB code: 9g6e:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:110.8 occ:1.00 N A:GLY248 3.2 85.0 1.0 N A:PHE514 3.4 64.1 1.0 N A:ILE515 3.5 65.6 1.0 CA A:GLY245 3.5 67.3 1.0 C A:GLY245 3.6 69.4 1.0 CA A:GLY512 3.6 64.5 1.0 CG1 A:ILE515 3.7 71.0 1.0 N A:GLU247 3.7 90.7 1.0 CB A:PHE514 3.7 66.8 1.0 N A:VAL513 3.7 67.9 1.0 C A:GLY512 3.8 65.3 1.0 O A:GLY245 3.8 70.5 1.0 CD2 A:PHE514 3.9 73.8 1.0 CA A:PHE514 3.9 64.9 1.0 CB A:GLU247 4.0 91.0 1.0 CA A:GLY248 4.0 83.6 1.0 C A:GLU247 4.1 92.1 1.0 CA A:GLU247 4.1 90.7 1.0 CG A:PHE514 4.1 70.2 1.0 N A:LYS246 4.2 73.7 1.0 CB A:ILE515 4.2 67.6 1.0 C A:PHE514 4.2 66.7 1.0 N A:GLY245 4.3 67.8 1.0 C A:VAL513 4.3 64.3 1.0 OE1 A:GLU247 4.4 93.4 1.0 CA A:ILE515 4.4 65.7 1.0 N A:GLY512 4.5 63.5 1.0 O A:GLY512 4.5 69.0 1.0 CA A:VAL513 4.5 68.3 1.0 CD1 A:ILE515 4.6 69.3 1.0 CD A:PRO516 4.7 56.0 1.0 C A:LYS246 4.7 76.9 1.0 CL A:CL902 4.7 139.7 1.0 CE2 A:PHE514 4.9 75.8 1.0 CA A:LYS246 5.0 74.0 1.0 CD A:PRO249 5.0 73.3 1.0

Chlorine binding site 2 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:139.7 occ:1.00 N A:VAL513 3.0 67.9 1.0 CZ A:PHE514 3.4 72.2 1.0 CB A:SER204 3.4 70.3 1.0 CE2 A:PHE514 3.4 75.8 1.0 OG A:SER204 3.4 73.9 1.0 CA A:GLY512 3.6 64.5 1.0 CG1 A:VAL513 3.6 67.3 1.0 CE1 A:PHE514 3.6 70.8 1.0 CD2 A:PHE514 3.7 73.8 1.0 C A:GLY512 3.8 65.3 1.0 CD1 A:PHE514 3.9 71.1 1.0 CA A:VAL513 3.9 68.3 1.0 CG A:PHE514 4.0 70.2 1.0 N A:PHE514 4.0 64.1 1.0 CB A:VAL513 4.1 67.2 1.0 CA A:GLY248 4.3 83.6 1.0 C A:VAL513 4.4 64.3 1.0 CL A:CL901 4.7 110.8 1.0 CD1 A:ILE206 4.7 72.4 1.0 CA A:SER204 4.8 67.0 1.0 N A:GLY512 4.9 63.5 1.0 O A:ALA511 5.0 77.6 1.0 O A:GLY512 5.0 69.0 1.0 CB A:PHE514 5.0 66.8 1.0

Chlorine binding site 3 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:110.1 occ:1.00 OE1 A:GLN208 3.0 88.1 1.0 N A:GLY205 3.0 68.1 1.0 O A:ALA202 3.3 73.3 1.0 CA A:GLY205 3.5 65.9 1.0 N A:SER204 3.7 71.6 1.0 CA A:GLY203 3.8 55.0 1.0 CD A:PRO207 3.8 73.4 1.0 C A:GLY203 3.9 61.2 1.0 CD A:GLN208 4.0 86.8 1.0 C A:SER204 4.2 69.5 1.0 C A:GLY205 4.2 66.5 1.0 C A:ALA202 4.3 67.1 1.0 CG A:PRO207 4.3 78.7 1.0 OG A:SER204 4.3 73.9 1.0 NE2 A:GLN208 4.4 89.4 1.0 CA A:SER204 4.4 67.0 1.0 N A:ILE206 4.5 74.6 1.0 N A:GLY203 4.5 60.0 1.0 O A:GLY203 4.7 63.3 1.0 N A:PRO207 4.8 74.9 1.0 CB A:PRO207 4.8 79.0 1.0

Chlorine binding site 4 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:106.3 occ:1.00 N C:GLY248 3.3 85.2 1.0 N C:PHE514 3.4 65.2 1.0 N C:ILE515 3.5 63.0 1.0 CA C:GLY245 3.6 63.7 1.0 C C:GLY245 3.6 66.8 1.0 CA C:GLY512 3.6 67.7 1.0 CG1 C:ILE515 3.7 69.3 1.0 N C:GLU247 3.7 88.3 1.0 CB C:PHE514 3.7 70.3 1.0 N C:VAL513 3.7 66.4 1.0 C C:GLY512 3.8 68.3 1.0 O C:GLY245 3.8 68.4 1.0 CA C:PHE514 3.9 67.3 1.0 CD2 C:PHE514 3.9 75.1 1.0 CB C:GLU247 4.0 89.0 1.0 CA C:GLY248 4.0 85.0 1.0 C C:GLU247 4.1 89.0 1.0 CA C:GLU247 4.1 88.0 1.0 CG C:PHE514 4.1 72.8 1.0 CB C:ILE515 4.2 65.2 1.0 C C:PHE514 4.2 68.1 1.0 N C:LYS246 4.2 71.6 1.0 N C:GLY245 4.3 65.7 1.0 C C:VAL513 4.3 63.0 1.0 OE1 C:GLU247 4.4 92.3 1.0 CA C:ILE515 4.4 61.9 1.0 N C:GLY512 4.5 65.8 1.0 O C:GLY512 4.5 72.8 1.0 CA C:VAL513 4.6 65.0 1.0 CD1 C:ILE515 4.6 68.0 1.0 CD C:PRO516 4.7 54.4 1.0 C C:LYS246 4.7 74.6 1.0 CL C:CL903 4.7 138.7 1.0 CE2 C:PHE514 5.0 77.5 1.0 CD C:PRO249 5.0 76.8 1.0 CA C:LYS246 5.0 72.9 1.0

Chlorine binding site 5 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl903 b:138.7 occ:1.00 N C:VAL513 3.0 66.4 1.0 CZ C:PHE514 3.4 74.8 1.0 CB C:SER204 3.4 71.7 1.0 CE2 C:PHE514 3.4 77.5 1.0 OG C:SER204 3.4 73.4 1.0 CA C:GLY512 3.6 67.7 1.0 CG1 C:VAL513 3.6 66.9 1.0 CE1 C:PHE514 3.6 72.6 1.0 CD2 C:PHE514 3.7 75.1 1.0 C C:GLY512 3.8 68.3 1.0 CD1 C:PHE514 3.9 73.6 1.0 CA C:VAL513 3.9 65.0 1.0 CG C:PHE514 4.0 72.8 1.0 N C:PHE514 4.0 65.2 1.0 CB C:VAL513 4.1 63.8 1.0 CA C:GLY248 4.3 85.0 1.0 C C:VAL513 4.4 63.0 1.0 CL C:CL902 4.7 106.3 1.0 CD1 C:ILE206 4.8 66.2 1.0 CA C:SER204 4.8 68.6 1.0 N C:GLY512 4.9 65.8 1.0 O C:ALA511 5.0 77.5 1.0 CB C:PHE514 5.0 70.3 1.0 O C:GLY512 5.0 72.8 1.0

Chlorine binding site 6 out of 6 in the CLC7(Y715C)/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of CLC7(Y715C)/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl904 b:129.2 occ:1.00 NE2 C:GLN208 2.6 93.0 1.0 N C:GLY205 3.1 71.3 1.0 O C:ALA202 3.3 76.3 1.0 CA C:GLY205 3.5 69.6 1.0 CD C:GLN208 3.7 91.1 1.0 N C:SER204 3.8 70.4 1.0 CD C:PRO207 3.9 73.8 1.0 CA C:GLY203 3.9 55.8 1.0 OE1 C:GLN208 4.0 94.2 1.0 C C:GLY203 4.0 59.6 1.0 C C:GLY205 4.2 69.8 1.0 C C:SER204 4.2 70.7 1.0 CG C:PRO207 4.3 78.3 1.0 C C:ALA202 4.3 70.3 1.0 N C:ILE206 4.5 68.3 1.0 OG C:SER204 4.5 73.4 1.0 CA C:SER204 4.6 68.6 1.0 N C:GLY203 4.6 58.9 1.0 CB C:PRO207 4.8 77.4 1.0 N C:PRO207 4.8 74.8 1.0 O C:GLY203 4.8 63.7 1.0 CG C:GLN208 5.0 88.5 1.0 O C:GLY205 5.0 71.3 1.0 N C:GLN208 5.0 86.2 1.0

J.Hilton, Y.Lin, E.Sefah, J.C.Deme, J.Parker, M.J.Langton, M.Grabe, S.Lea, S.Newstead, J.A.Mindell. Mechanism of Phosphoinositide Regulation of Lysosomal pH Via Inhibition of CLC7 To Be Published.