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Chlorine in PDB 9mg5: Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp

Enzymatic activity of Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp

All present enzymatic activity of Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp:
2.1.1.56;

Protein crystallography data

The structure of Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp, PDB code: 9mg5 was solved by D.J.Nilson, E.Fedorov, A.Ghosh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.87 / 1.45
Space group P 63
Cell size a, b, c (Å), α, β, γ (°) 95.732, 95.732, 129.256, 90, 90, 120
R / Rfree (%) 10.8 / 12.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp (pdb code 9mg5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp, PDB code: 9mg5:

Chlorine binding site 1 out of 1 in 9mg5

Go back to Chlorine Binding Sites List in 9mg5
Chlorine binding site 1 out of 1 in the Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Saccharomyces Cerevisiae Mrna Cap (Guanine-N7) Methyltransferase, ABD1, in Complex with Sinefungin and Gtp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl520

b:56.9
occ:1.00
 HE B:ARG180 2.5 42.5 1.0
HH21 B:ARG180 2.7 50.3 1.0
HE3 B:MET210 2.8 31.2 1.0
HG2 B:MET210 3.3 37.6 1.0
NE B:ARG180 3.4 35.4 1.0
NH2 B:ARG180 3.4 41.9 1.0
CE B:MET210 3.8 26.0 1.0
HB2 B:ARG180 3.8 25.4 1.0
CZ B:ARG180 3.9 34.4 1.0
HG2 B:ARG180 4.0 62.4 1.0
HH22 B:ARG180 4.1 50.3 1.0
CG B:MET210 4.2 31.4 1.0
HE2 B:MET210 4.2 31.2 1.0
HE1 B:MET210 4.3 31.2 1.0
HB3 B:MET210 4.5 24.9 1.0
SD B:MET210 4.5 29.8 1.0
CD B:ARG180 4.5 43.0 1.0
CG B:ARG180 4.5 52.0 1.0
CB B:ARG180 4.6 21.2 1.0
HG3 B:MET210 4.8 37.6 1.0
CB B:MET210 4.9 20.8 1.0
HD2 B:ARG180 4.9 51.6 1.0
HA B:MET210 4.9 32.5 1.0
HB3 B:ARG180 5.0 25.4 1.0

Reference:

D.J.Nilson, B.Schwer, S.Shuman, S.C.Almo. Structural Basis For Sensitivity and Acquired Resistance of Fungal Cap Guanine-N7 Methyltransferases to the Antifungal Antibiotic Sinefungin Nucleic Acids Res. 2025.
ISSN: ESSN 1362-4962
DOI: 10.1093/NAR/GKAF538
Page generated: Mon Aug 4 21:13:07 2025

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