Chlorine in PDB 2oz7: Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate

The structure of Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate, PDB code: 2oz7 was solved by C.E.Bohl, Z.Wu, D.D.Miller, C.E.Bell, J.T.Dalton, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	21.96 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.504, 65.820, 71.506, 90.00, 90.00, 90.00
R / Rfree (%)	25.3 / 27

The binding sites of Chlorine atom in the Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate (pdb code 2oz7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate, PDB code: 2oz7:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Androgen Receptor T877A Mutant Ligand- Binding Domain with Cyproterone Acetate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1 b:3.6 occ:1.00 CL6 A:CA41 0.0 3.6 1.0 C6 A:CA41 1.7 17.8 1.0 C5 A:CA41 2.7 18.2 1.0 C7 A:CA41 2.7 17.2 1.0 C4 A:CA41 2.9 21.2 1.0 SD A:MET787 3.7 23.0 1.0 CG2 A:VAL746 3.8 19.0 1.0 CD1 A:LEU873 4.0 17.1 1.0 CE2 A:PHE764 4.1 20.1 1.0 C10 A:CA41 4.1 21.1 1.0 CA A:VAL746 4.1 20.2 1.0 C8 A:CA41 4.1 19.9 1.0 CE A:MET787 4.2 23.3 1.0 N A:VAL746 4.2 18.6 1.0 C3 A:CA41 4.3 23.9 1.0 C A:MET745 4.4 21.1 1.0 O A:MET745 4.5 21.2 1.0 C19 A:CA41 4.6 20.1 1.0 C9 A:CA41 4.6 20.5 1.0 CB A:VAL746 4.6 20.3 1.0 CE A:MET749 4.6 23.5 1.0 CB A:MET745 4.7 20.8 1.0 SD A:MET742 4.7 23.4 1.0 CD2 A:PHE764 4.8 19.6 1.0 O3 A:CA41 4.9 23.1 1.0

C.E.Bohl, Z.Wu, D.D.Miller, C.E.Bell, J.T.Dalton. Crystal Structure of the T877A Human Androgen Receptor Ligand-Binding Domain Complexed to Cyproterone Acetate Provides Insight For Ligand-Induced Conformational Changes and Structure-Based Drug Design. J.Biol.Chem. V. 282 13648 2007.
ISSN: ISSN 0021-9258
PubMed: 17311914
DOI: 10.1074/JBC.M611711200