Chlorine in PDB 2wzq: Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus

The structure of Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus, PDB code: 2wzq was solved by D.Luo, N.Wei, D.Doan, P.Paradkar, Y.Chong, A.Davidson, M.Kotaka, J.Lescar, S.Vasudevan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	52.420, 87.720, 75.779, 90.00, 92.90, 90.00
R / Rfree (%)	22 / 28.8

The binding sites of Chlorine atom in the Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus (pdb code 2wzq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus, PDB code: 2wzq:

Chlorine binding site 1 out of 1 in the Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insertion Mutant E173GP174 of the NS3 Protease-Helicase From Dengue Virus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1620 b:75.0 occ:1.00 OG1 A:THR409 3.1 20.5 1.0 N A:ARG388 3.5 28.2 1.0 CG2 A:THR409 3.6 18.1 1.0 CB A:THR409 3.7 19.1 1.0 CB A:SER387 3.7 26.8 1.0 CB A:ARG388 4.0 29.3 1.0 CA A:SER387 4.1 26.7 1.0 CD1 A:ILE366 4.2 27.0 1.0 C A:SER387 4.3 27.4 1.0 CD A:ARG388 4.3 33.5 1.0 CA A:ARG388 4.4 28.9 1.0 NE A:ARG388 4.5 36.1 1.0 OG A:SER387 4.7 27.8 1.0 CG A:ARG388 4.8 30.8 1.0 CZ A:ARG388 4.8 37.7 1.0 CG1 A:ILE366 4.9 24.9 1.0

D.Luo, N.Wei, D.N.Doan, P.N.Paradkar, Y.Chong, A.D.Davidson, M.Kotaka, J.Lescar, S.G.Vasudevan. Flexibility Between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred By the Linker Region and Its Functional Implications. J.Biol.Chem. V. 285 18817 2010.
ISSN: ISSN 0021-9258
PubMed: 20375022
DOI: 10.1074/JBC.M109.090936