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Chlorine in PDB 2xs6: Crystal Structure of the Rhogap Domain of Human PIK3R2

Protein crystallography data

The structure of Crystal Structure of the Rhogap Domain of Human PIK3R2, PDB code: 2xs6 was solved by L.Tresaugues, M.Welin, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, I.Johansson, T.Karlberg, S.Kol, T.Kotenyova, E.Kouznetsova, M.Moche, T.Nyman, C.Persson, H.Schuler, P.Schutz, M.I.Siponen, A.G.Thorsell, S.Van Der Berg, E.Wahlberg, J.Weigelt, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 53.92 / 2.09
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 94.661, 34.354, 71.317, 90.00, 130.88, 90.00
R / Rfree (%) 19.149 / 23.98

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Rhogap Domain of Human PIK3R2 (pdb code 2xs6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Rhogap Domain of Human PIK3R2, PDB code: 2xs6:

Chlorine binding site 1 out of 1 in 2xs6

Go back to Chlorine Binding Sites List in 2xs6
Chlorine binding site 1 out of 1 in the Crystal Structure of the Rhogap Domain of Human PIK3R2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Rhogap Domain of Human PIK3R2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1295

b:31.6
occ:1.00
O A:HOH2064 3.0 35.7 1.0
NH1 A:ARG218 3.3 28.7 1.0
CG A:ARG218 3.6 24.5 1.0
N A:ARG218 3.6 23.5 1.0
CB A:PRO215 3.6 32.2 1.0
CB A:HIS217 3.7 24.4 1.0
CD A:ARG218 3.7 27.1 1.0
CG A:PRO115 3.7 29.9 1.0
O A:HOH2003 3.8 47.1 1.0
CD A:PRO115 3.8 27.7 1.0
CB A:ARG218 4.0 24.2 1.0
N A:HIS217 4.2 27.3 1.0
CG A:PRO215 4.2 33.8 1.0
CA A:HIS217 4.3 25.1 1.0
CZ A:ARG218 4.3 28.3 1.0
C A:HIS217 4.4 23.1 1.0
CA A:ARG218 4.4 22.8 1.0
O A:PRO215 4.4 28.7 1.0
NE A:ARG218 4.5 28.1 1.0
CB A:LEU114 4.5 22.7 1.0
C A:PRO215 4.5 31.3 1.0
CG A:HIS217 4.6 25.8 1.0
ND1 A:HIS217 4.6 28.7 1.0
CA A:PRO215 4.7 33.7 1.0
N A:PRO115 4.7 25.6 1.0
CD A:PRO215 4.8 33.3 1.0

Reference:

S.M.Lim, K.Yeung, L.Tresaugues, T.H.Ling, P.Nordlund. The Structure and Catalytic Mechanism of Human Sphingomyelin Phosphodiesterase Like 3A - An Acid Sphingomyelinase Homolog with A Novel Nucleotide Hydrolase Activity. Febs J. V. 283 1107 2016.
ISSN: ISSN 1742-464X
PubMed: 26783088
DOI: 10.1111/FEBS.13655
Page generated: Fri Jul 11 02:07:37 2025

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