Chlorine in PDB 3isq: Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase

All present enzymatic activity of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase:
1.13.11.27;

The structure of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase, PDB code: 3isq was solved by E.S.Pilka, N.Shafqat, R.Cocking, J.E.Bray, T.Krojer, A.C.W.Pike, F.Vondelft, W.W.Yue, C.H.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann, K.L.Kavanagh, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.60 / 1.75
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	99.206, 99.206, 87.726, 90.00, 90.00, 120.00
R / Rfree (%)	14.4 / 17.4

The structure of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase also contains other interesting chemical elements:

Cobalt	(Co)	1 atom
Sodium	(Na)	1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase (pdb code 3isq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase, PDB code: 3isq:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:20.1 occ:1.00 O A:HOH444 2.1 10.9 0.5 O A:HOH740 2.2 26.1 1.0 O A:HOH438 2.2 21.8 1.0 O A:HOH859 2.3 14.9 0.5 NE2 A:HIS218 2.4 20.9 1.0 O A:HOH859 2.8 11.1 0.5 O A:HOH444 3.0 16.6 0.5 CD2 A:HIS218 3.3 17.9 1.0 CE1 A:HIS218 3.3 18.6 1.0 OE2 A:GLU220 4.1 28.1 1.0 O A:HOH439 4.3 26.9 1.0 O A:HOH459 4.4 41.7 1.0 ND1 A:HIS218 4.4 19.5 1.0 CG A:HIS218 4.5 14.6 1.0 O A:HOH781 4.5 41.5 1.0

E.S.Pilka, N.Shafqat, R.Cocking, J.E.Bray, T.Krojer, A.C.W.Pike, F.Von Delft, W.W.Yue, C.H.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann, K.L.Kavanagh. Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase To Be Published.