Chlorine in PDB 3lms: Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

Enzymatic activity of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

All present enzymatic activity of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.:
3.4.17.20;

Protein crystallography data

The structure of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci., PDB code: 3lms was solved by L.Sanglas, J.L.Arolas, Z.Valnickova, F.X.Aviles, J.J.Enghild, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	46.18 / 2.50
*Space group*	P 3₁ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	157.180, 157.180, 57.070, 90.00, 90.00, 120.00
*R / R_free (%)*	18.5 / 21.6

Other elements in 3lms:

The structure of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. also contains other interesting chemical elements:

Potassium	(K)	2 atoms
Calcium	(Ca)	1 atom
Zinc	(Zn)	1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. (pdb code 3lms). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci., PDB code: 3lms:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 3lms

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Chlorine Binding Sites List in 3lms

Chlorine binding site 1 out of 3 in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl506 b:42.6 occ:1.00	OH	A:TYR118	3.6	38.7	1.0
	O	A:HOH596	4.0	49.5	1.0
	O	A:HOH556	4.2	48.5	1.0
	CZ	A:TYR118	4.6	41.8	1.0
	CL	A:CL507	4.7	39.3	1.0
	CG2	B:THR29	4.7	46.7	1.0
	CD	A:LYS122	4.7	45.1	1.0
	CE1	A:TYR118	4.8	40.2	1.0
	O	A:HOH549	4.8	41.0	1.0

Chlorine binding site 2 out of 3 in 3lms

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Chlorine Binding Sites List in 3lms

Chlorine binding site 2 out of 3 in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl507 b:39.3 occ:1.00	CA	A:CA509	2.9	63.9	1.0
	NZ	A:LYS122	3.8	45.7	1.0
	O	A:HOH596	4.0	49.5	1.0
	CE	A:LYS122	4.1	45.7	1.0
	CL	A:CL506	4.7	42.6	1.0

Chlorine binding site 3 out of 3 in 3lms

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Chlorine Binding Sites List in 3lms

Chlorine binding site 3 out of 3 in the Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci.

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor, Tafia, in Complex with Tick-Derived Funnelin Inhibitor, Tci. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Cl508 b:52.1 occ:1.00	CA	A:CA509	2.9	63.9	1.0
	OG	B:SER28	3.1	51.2	1.0
	O	B:HOH516	3.4	53.5	1.0
	CB	B:SER28	3.7	50.7	1.0
	CE	A:LYS122	3.8	45.7	1.0
	NZ	A:LYS122	4.0	45.7	1.0

Reference:

L.Sanglas, J.L.Arolas, Z.Valnickova, F.X.Aviles, J.J.Enghild, F.X.Gomis-Ruth. Insights Into the Molecular Inactivation Mechanism of Human Activated Thrombin-Activatable Fibrinolysis Inhibitor J.Thromb.Haemost. V. 8 1056 2010.
ISSN: ISSN 1538-7933
PubMed: 20088943
DOI: 10.1111/J.1538-7836.2010.03740.X

Page generated: Sat Dec 12 09:53:22 2020

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