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Atomistry » Chlorine » PDB 3zx3-4a7i » 3zze | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 3zx3-4a7i » 3zze » |
Chlorine in PDB 3zze: Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)PropanohydrazideEnzymatic activity of Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide
All present enzymatic activity of Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide, PDB code: 3zze
was solved by
M.Mctigue,
Y.Deng,
K.Ryan,
J.J.Cui,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide
(pdb code 3zze). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide, PDB code: 3zze: Chlorine binding site 1 out of 1 in 3zzeGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of C-Met Kinase Domain in Complex with N'-((3Z)-4- Chloro-7-Methyl-2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)-2-(4- Hydroxyphenyl)Propanohydrazide
![]() Mono view ![]() Stereo pair view
Reference:
J.J.Cui,
M.Mctigue,
M.Nambu,
M.Tran-Dube,
M.Pairish,
H.Shen,
L.Jia,
H.Cheng,
J.Hoffman,
P.Le,
M.Jalaie,
G.H.Goetz,
K.Ryan,
N.Grodsky,
Y.Deng,
M.Parker,
S.Timofeevski,
B.W.Murray,
S.Yamazaki,
S.Aguirre,
Q.Li,
H.Zou,
J.Christensen.
Discovery of A Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (C-Met) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-Ylmethyl)-1H-[1,2, 3]Triazolo[4,5-B]Pyrazin-6-Yl)-1H-Pyrazol-1-Yl)Ethanol (Pf-04217903) For the Treatment of Cancer. J.Med.Chem. V. 55 8091 2012.
Page generated: Fri Jul 11 12:35:39 2025
ISSN: ISSN 0022-2623 PubMed: 22924734 DOI: 10.1021/JM300967G |
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