Chlorine in PDB 4a1y: Human Myelin P2 Protein, K65Q Mutant

The structure of Human Myelin P2 Protein, K65Q Mutant, PDB code: 4a1y was solved by M.Lehtimaki, P.Kursula, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.20
Space group	P 43
Cell size a, b, c (Å), α, β, γ (°)	83.030, 83.030, 77.900, 90.00, 90.00, 90.00
R / Rfree (%)	13.1 / 15.4

The binding sites of Chlorine atom in the Human Myelin P2 Protein, K65Q Mutant (pdb code 4a1y). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Human Myelin P2 Protein, K65Q Mutant, PDB code: 4a1y:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Human Myelin P2 Protein, K65Q Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Myelin P2 Protein, K65Q Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1133 b:32.1 occ:1.00 O A:HOH1327 3.3 35.9 1.0 N A:LYS37 3.3 19.4 1.0 N A:THR56 3.3 17.7 1.0 CG2 A:THR56 3.5 21.9 1.0 CB A:SER55 3.6 15.1 1.0 CA A:SER55 3.7 14.2 1.0 CA A:ALA36 3.8 18.7 1.0 OG1 A:THR56 3.9 29.4 1.0 C A:LYS37 3.9 18.9 1.0 O A:LYS37 4.0 20.7 1.0 CB A:ALA36 4.0 18.2 1.0 C A:ALA36 4.0 19.5 1.0 C A:SER55 4.1 15.8 1.0 CB A:THR56 4.1 19.9 1.0 O A:HOH1319 4.2 42.9 1.0 CA A:LYS37 4.2 21.7 1.0 CA A:THR56 4.3 19.6 1.0 N A:PRO38 4.4 15.4 1.0 CB A:LYS37 4.7 23.4 1.0 CA A:PRO38 4.7 14.6 1.0 OG A:SER55 4.7 17.9 1.0 O A:HOH1331 4.9 26.3 1.0

Chlorine binding site 2 out of 3 in the Human Myelin P2 Protein, K65Q Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Myelin P2 Protein, K65Q Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1133 b:24.8 occ:1.00 N C:LYS37 3.2 17.2 1.0 N C:THR56 3.3 16.5 1.0 OG1 C:THR56 3.4 25.9 1.0 O C:HOH1284 3.7 52.7 1.0 CB C:SER55 3.7 14.2 1.0 CA C:SER55 3.7 13.2 1.0 CA C:ALA36 3.7 16.8 1.0 O C:LYS37 3.9 17.8 1.0 C C:LYS37 3.9 16.3 1.0 CB C:ALA36 4.0 16.5 1.0 C C:ALA36 4.0 17.9 1.0 C C:SER55 4.0 14.9 1.0 CB C:THR56 4.1 19.0 1.0 CA C:LYS37 4.2 17.8 1.0 CA C:THR56 4.3 17.1 1.0 N C:PRO38 4.4 14.4 1.0 CA C:PRO38 4.7 14.2 1.0 CB C:LYS37 4.8 20.3 1.0 OG C:SER55 4.8 16.2 1.0 O C:HOH1373 5.0 33.4 1.0 N C:ALA36 5.0 16.1 1.0

Chlorine binding site 3 out of 3 in the Human Myelin P2 Protein, K65Q Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Myelin P2 Protein, K65Q Mutant within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1132 b:23.6 occ:1.00 N D:LYS37 3.2 15.9 1.0 N D:THR56 3.4 16.2 0.5 N D:THR56 3.4 16.3 0.5 CB D:SER55 3.6 14.8 1.0 OG1 D:THR56 3.6 18.7 0.5 OG1 D:THR56 3.7 20.4 0.5 CA D:SER55 3.7 13.6 1.0 CA D:ALA36 3.8 14.6 1.0 O D:LYS37 3.8 17.9 1.0 C D:LYS37 3.9 16.7 1.0 CB D:ALA36 4.0 15.2 1.0 C D:ALA36 4.0 14.2 1.0 C D:SER55 4.1 15.0 1.0 CA D:LYS37 4.2 16.0 1.0 CG2 D:THR56 4.2 18.1 0.5 CB D:THR56 4.3 16.8 0.5 CB D:THR56 4.3 16.8 0.5 CA D:THR56 4.4 16.8 0.5 N D:PRO38 4.4 14.8 1.0 CA D:THR56 4.4 16.7 0.5 O D:HOH1258 4.5 49.5 1.0 OG D:SER55 4.6 15.5 1.0 CA D:PRO38 4.7 13.4 1.0 CB D:LYS37 4.7 18.3 1.0 O D:HOH1350 4.9 33.9 1.0

M.Lehtimaki, P.Kursula. Structure-Function Relationships in the Myelin Peripheral Membrane Protein P2 To Be Published.