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Chlorine in PDB 4f9c: Human CDC7 Kinase in Complex with DBF4 and XL413

Enzymatic activity of Human CDC7 Kinase in Complex with DBF4 and XL413

All present enzymatic activity of Human CDC7 Kinase in Complex with DBF4 and XL413:
2.7.11.1;

Protein crystallography data

The structure of Human CDC7 Kinase in Complex with DBF4 and XL413, PDB code: 4f9c was solved by S.Hughes, P.Cherepanov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.74 / 2.08
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 61.270, 61.270, 238.940, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 24.9

Other elements in 4f9c:

The structure of Human CDC7 Kinase in Complex with DBF4 and XL413 also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human CDC7 Kinase in Complex with DBF4 and XL413 (pdb code 4f9c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human CDC7 Kinase in Complex with DBF4 and XL413, PDB code: 4f9c:

Chlorine binding site 1 out of 1 in 4f9c

Go back to Chlorine Binding Sites List in 4f9c
Chlorine binding site 1 out of 1 in the Human CDC7 Kinase in Complex with DBF4 and XL413


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human CDC7 Kinase in Complex with DBF4 and XL413 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl601

b:37.5
occ:1.00
CL A:0SX601 0.0 37.5 1.0
CAM A:0SX601 1.8 32.0 1.0
CAC A:0SX601 2.8 30.0 1.0
CAE A:0SX601 2.8 31.4 1.0
O A:LEU137 3.5 42.1 1.0
CD1 A:TYR136 3.5 39.7 1.0
N A:LEU137 3.6 39.1 1.0
CD1 A:LEU184 3.8 31.6 1.0
CE1 A:TYR136 3.9 41.6 1.0
CE1 A:HIS139 4.0 34.9 1.0
CD1 A:ILE64 4.0 47.6 1.0
CAQ A:0SX601 4.0 30.9 1.0
CAD A:0SX601 4.0 29.1 1.0
ND1 A:HIS139 4.1 31.8 1.0
CB A:ALA88 4.2 28.2 1.0
CA A:TYR136 4.2 37.8 1.0
C A:LEU137 4.3 38.6 1.0
CG A:TYR136 4.4 39.9 1.0
C A:TYR136 4.4 38.3 1.0
CA A:LEU137 4.4 39.8 1.0
CAP A:0SX601 4.5 30.2 1.0
O A:PRO135 4.7 33.7 1.0
CB A:TYR136 4.8 38.3 1.0
CB A:LEU137 4.8 39.9 1.0
CD2 A:LEU184 4.9 29.3 1.0
CG A:LEU184 4.9 31.9 1.0
CZ A:TYR136 5.0 42.1 1.0

Reference:

S.Hughes, F.Elustondo, A.Di Fonzo, F.G.Leroux, A.C.Wong, A.P.Snijders, S.J.Matthews, P.Cherepanov. Crystal Structure of Human CDC7 Kinase in Complex with Its Activator DBF4. Nat.Struct.Mol.Biol. V. 19 1101 2012.
ISSN: ISSN 1545-9993
PubMed: 23064647
DOI: 10.1038/NSMB.2404
Page generated: Sat Dec 12 10:36:39 2020

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