Chlorine in PDB 4mnf: Crystal Structure of Braf-V600E Bound to GDC0879

All present enzymatic activity of Crystal Structure of Braf-V600E Bound to GDC0879:
2.7.11.1;

The structure of Crystal Structure of Braf-V600E Bound to GDC0879, PDB code: 4mnf was solved by J.Sudhamsu, J.R.Haling, T.Morales, B.Brandhuber, S.G.Hymowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.87 / 2.80
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	99.740, 99.740, 159.032, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 27.5

The binding sites of Chlorine atom in the Crystal Structure of Braf-V600E Bound to GDC0879 (pdb code 4mnf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Braf-V600E Bound to GDC0879, PDB code: 4mnf:

Chlorine binding site 1 out of 1 in the Crystal Structure of Braf-V600E Bound to GDC0879


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Braf-V600E Bound to GDC0879 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl802 b:9.7 occ:1.00 NZ A:LYS591 3.5 34.4 1.0 NZ B:LYS591 3.8 45.7 1.0 CE1 B:HIS585 4.1 57.1 1.0 CG2 B:VAL511 4.1 20.5 1.0 CD2 A:HIS585 4.1 32.9 1.0 CE A:LYS591 4.1 35.4 1.0 NE2 A:GLN530 4.2 35.8 1.0 CE B:LYS591 4.3 39.6 1.0 NE2 B:GLN530 4.3 48.2 1.0 O B:HOH901 4.5 20.4 1.0 NE2 A:HIS585 4.5 52.7 1.0 ND1 B:HIS585 4.5 46.7 1.0

J.R.Haling, J.Sudhamsu, I.Yen, S.Sideris, W.Sandoval, W.Phung, B.J.Bravo, A.M.Giannetti, A.Peck, A.Masselot, T.Morales, D.Smith, B.J.Brandhuber, S.G.Hymowitz, S.Malek. Structure of the Braf-Mek Complex Reveals A Kinase Activity Independent Role For Braf in Mapk Signaling. Cancer Cell V. 26 402 2014.
ISSN: ISSN 1535-6108
PubMed: 25155755
DOI: 10.1016/J.CCR.2014.07.007