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Chlorine in PDB 4whz: Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
Enzymatic activity of Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
All present enzymatic activity of Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives:
2.7.11.24;
2.7.11.24;
Protein crystallography data
The structure of Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives, PDB code: 4whz
was solved by
H.Park,
P.Lograsso,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.24 / 1.79 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 53.920, 70.930, 107.690, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.3 / 22.7 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
(pdb code 4whz). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives, PDB code: 4whz:
In total only one binding site of Chlorine was determined in the Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives, PDB code: 4whz:
Chlorine binding site 1 out of 1 in 4whz
Go back to
Chlorine Binding Sites List in 4whz
Chlorine binding site 1 out
of 1 in the Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives within 5.0Å range:
|
Reference:
K.Zheng,
S.Iqbal,
P.Hernandez,
H.Park,
P.V.Lograsso,
Y.Feng.
Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: Sar Studies on Aminopyrazole Derivatives. J.Med.Chem. 2014.
ISSN: ISSN 0022-2623
PubMed: 25393557
DOI: 10.1021/JM501256Y
Page generated: Fri Jul 26 02:54:47 2024
ISSN: ISSN 0022-2623
PubMed: 25393557
DOI: 10.1021/JM501256Y
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